In the last few years, there have been significant breakthroughs in the field of longevity and anti-aging. NDA+ research field attracted key scientists who been looking for to unlock cell rejuvenation.
There are two precursors to NDA+ that are talked about in the supplement community the most:
- NR, or nicotinamide riboside
- NMN, or nicotinamide mononucleotide
I wanted to take a look more into NMN to see if it is as effective as taking NR supplement does for increasing NDA+ levels naturally.
People around the world spend billions of dollars on antiaging products annually. The most common reason that people use these products is to reverse signs of aging (skin & body)!
Today, there is constant pressure to appear younger. Recent studies into NDA+ shows promising results in not only reversing the appearance of aging but also in healing tissue on a cellular level.
This review is going to go over the top NMN supplements, what they do to your body, and if they are worth your attention & investment. After that, I will talk about studies and science!
Top-Rated & Best NMN Supplement Brands
There is a wide variety of NMN supplement brands, which are produced by dietary supplement companies. Some products on the market are ineffective or provided by companies that are not trustworthy.
We took an in-depth look at three of the top-rated NMN supplement brands.
ALIVE BY NATURE SUBLINGUAL PURE NMN / Review
Alive By Nature’s pure NMN is a sublingual, high-quality fast dissolving tablet. By making the tablet sublingual, the supplement can be absorbed quickly into the blood vessels under the tongue.
This NMN has a low PH and lower molecular weight for better balance and faster delivery. The tablets give 125mg of NMN and are sweetened with monk fruit extract. They are vegan, keto-friendly, and GMO-free.
The company Alive By Nature is a newer company, but they adhere to strict regulations and standards. If you are looking to try NMN powder that is third-party tested in your supplement routine, this may be an excellent choice. It’s attractive to want to save cash, but with NMN exactly, you receive what you pay for. Lower-cost NMN will probably be food-grade products, not pharmaceutical-grade.
PROHEALTH NMN Supplement
ProHealth offers a lozenge form of NMN. Each lozenge contains150 mg of NMN, xylitol, and natural lemon flavoring.
They are all-natural, keto-friendly, non-GMO, vegan, and free of soy, and artificial colors or flavors.
The company triple tests this supplement to guarantee potency and purity. In the lozenge form, the NMN is thought to be more bioavailable.
If you are looking for an NMN brand that you can trust, this might be a good choice. The only drawback is the inclusion of xylitol, sugar alcohol, that makes these lozenges sugar free. Some people may have a laxative effect from ingesting sugar alcohols.
MAAC10 – 125MG
Maac10 offers a bottle of 125 mg NMN capsules. They claim that this product is 99% pure NMN and also contains a newly discovered NMN transporter called Slc12a8.
Unlike other NMN supplements with average good ingredients, this company opted for capsules to be swallowed and absorbed in the digestive system.
According to the site Fake Spot; this product received a C score for accurate reviews.
The feedback of the site is disconcerting for many in the supplement industry because it implies that they paid for good reviews.
Many of them may be fake, and deception may be involved. If this is true, it should dissuade buyers from purchasing from this company.
Quicksilver NAD+ Gold Liposomal
The Quicksilver supplement is called Quicksilver NAD+ Gold. This is the only product from our list that delivers NMN in a form of liposomal. Dr. Christopher Shade, Ph.D. mentioned that liposomal NMN is possibly more bioavailable than NMN in powder form. It also comprises 50 mg of betaine (TMG) to help support methylation.
- The brand has been around for years
- Products are examined for Potency, COA, Potency, Heavy Metals, Particle Sizing, and Ingredient Purity
- Good customer service. Also available at their physical location, You can call their customer support line or send a support email
AN ALTERNATIVE TO NMN
Tru Niagen is a suitable alternative if NMN supplements aren’t right for you. Tru Niagen works by restoring the body’s NAD+ levels.
There are a variety of reasons that Tru Niagen is the top option for someone who is seeking rejuvenation treatment. It has been proven to have health benefits through plenty of studies and studies. Some of those health benefits include:
Tru Niagen is manufactured and distributed by ChromaDex. ChromaDex is a leading nutraceutical and biotech company, whose aim is to improve people’s health and livelihood.
Dr. Charles Brenner leads the ChromaDex Scientific Advisory Board. Dr. Brenner is a brilliant scientist who first discovered NR as a vitamin. Therefore, ChromaDex is continuously at the forefront of NAD+ studies and development.
NMN Supplement Research and Science
After significant breakthroughs in the studies conducted by Dr David Sinclair on NDA+ and its precursors, many companies and scientists began piggybacking off of the initial studies.
Dr. Sinclair is the leading investigator for NMN being used as a booster for NAD+ and as a rejuvenation supplement.
He has focused on the possible links between sirtuins, resveratrol, NAD (nicotinamide adenine dinucleotide), NMN, rejuvenation products, and calorie restriction throughout most of his career.
Dr. Samuel Klein from the Washington University School of Medicine in St. Louis conducted a study that was aimed at looking into NMN’s rejuvenation properties.
This clinical trial represents encouraging progress for NMN powder and antiaging studies; it illustrates that other members of the scientific community believe in the possible benefits of the NMN enzyme.
Professor Sinclair’s studies indicate that by increasing NAD, damage to the DNA can be reversed. This finding was mainly illustrated by studies that used NAD+ in elderly mice.
The NAD boost changed the tissue and appearance of elderly mice into those resembling much younger mice.
NAD+ ALSO REJUVENATES THE BODIES OF MICE
Sinclair’s earlier research has shown that NAD+ improved the tissue of mice on a cellular level.
These findings were incredible and unexpected; they sent a shockwave through the scientific community.
The mice that were given an oral NAD+ supplement compound regrew full coats of hair, had improved kidney function, and were able to run faster than before. Additionally, the mice that were treated with NAD+ had improved muscle mass and tone.
In these respects, they appeared to be similar to significantly younger mice.
Similar studies have been done to identify the methods of rejuvenation in mice and aim to apply those methods to humans.
The growing amount of interest and studies show that scientists may be close to finding a definitive link.
WHY DNA REPAIR DECLINES WITH AGE
According to studies by Dr. Sinclair and his team, they found that the protein DBC1 would latch on to a separate protein that helps repair damaged DNA.
As we age, the NAD+ in our bodies decreases, causing tissue damage and cell death. It has shown that NAD+ treatment could stop DBC1 from inhibiting DNA repair.
These studies is one of Dr. Sinclair’s most important career achievements. After the discovery of NAD’s effect on the DBC1 protein, Sinclair’s team knew that it was possible to reverse DNA damage.
DNA damage is a major source of common diseases related to aging, such as cancer, diabetes, heart disease, Alzheimer’s, and other cognitive disorders.
Our bodies possess the ability to repair damaged DNA, but this ability decreases with age. NAD+ is one of the most important components of this process.
The amount of NAD+ in the body also declines over our lifespan.
Increased amounts of the enzyme in mice helped to protect the DNA repair process.
If researchers can find a way to keep NAD+ levels high throughout life, they may be able to slow aging.
NAD+ MIMICS CALORIE RESTRICTION
Fasting and calorie restriction increases the body’s ability to repair and recycled cells through autophagy and reduced inflammation.
NDA+ can mimic the effects of a person who starves their body of calories; leading to increased longevity and decreases in the risk of cancers.
When calories are restricted, the body produces Nicotinamide phosphoribosyltransferase (NAMPT).
NAMPT is an enzyme that is critical to the creation of NAD+; thus, higher levels of NAMPT could be another method of rejuvenation treatment.
Results show that NAMPT is associated with rejuvenation.
While at Harvard in 1999, Sinclair found that the protein Sirtuin 1 (SIRT1) can delay aging in yeast.
SIRT1 rejuvenates yeast by decreasing the number of extrachromosomal rDNA circles.
Study results on the applications of SIRT1 are among the most significant discoveries for treatment.
There have been numerous studies that were inspired by Dr. Sinclair’s original research.
The results of these studies show that SIRT1 can rejuvenate yeast and potentially humans.
In 2003, Dr. Sinclair joined in on research that was being conducted by scientists at Biomol Research Laboratories.
The researchers at Biomol Labs found out that resveratrol could stimulate SIR2.
Dr. Sinclair was determined to work with the laboratory after hearing of this discovery.
Biomol Laboratories’ studies with Dr. Sinclair led to the discovery that resveratrol is an anti-aging compound; these findings were published in a 2003 issue of the Journal of Nature and Science.
David Sinclair on Anti-Aging NAD+ Fad & Human Trials of NMN
Professor David Sinclair, Ph.D. has dedicated his research to what he believes may be the best innovation in the field of antiaging.
Sinclair’s studies indicate that by boosting NAD+, he can repair DNA.
Through this, he has shown the world a possibility of a real-life “fountain of youth.”
Clinical trials on NDA+ that mimic those done on mice are still needed.
Dr. Sinclair has proposed a human study, and the world waits to see if the results are conclusive.
There have been studies into the two precursors of NDA+;
NMN is one of those NAD precursor molecules.
David believes that talking MNM as an anti-aging supplement may increase health span and life span in people.
Let’s review some of the most prominent NMN supplement studies and science.
Is NMN Safe (Side Effects)?
What are the side effects of nicotinamide riboside?
NMN does not currently have any safety indications from the United States FDA. This status is an indication that NMN is safe for use; the FDA.
is known to be a strict regulatory commission with rigorous guidelines.
Published scientific findings state that NR when compared to NMN, is a safer and more effective ingredient for raising NAD+ levels.
That doesn’t mean that NMN isn’t safe, but there may be more efficient rejuvenation treatments.
NR has had more clinical trials and studies than NMN, so more studies and further investigation is needed into NMN.
What Does Nicotinamide Mononucleotide Do?
Nicotinamide Mononucleotide (NMN) is a nucleotide, which is composed of NR. The main area of studies into NMN has been through animal study.
There is a lack of human clinical studies, despite encouraging evidence of tests performed on animals. These animal studies were looking at the neuroprotective and antiaging properties of the NMN compound.
There are a large number of dietary supplement companies that are marketing NMN as a proven rejuvenation treatment.
These advertisements shouldn’t be taken seriously because NMN hasn’t undergone any clinical trials on humans.
Again, that doesn’t mean that NMN supplements are not safe; it does mean that consumers should be informed when shopping for these supplements.
How to Take NMN
Dietary supplement companies frequently sell NMN as capsules or dissolvable tablets. However, in clinical studies on mice, NMN is administered through injections.
Currently, the only way for people to add NMN into their diet is by purchasing a supplement.
Further studies must be conducted to determine the most efficient method for humans to take NMN.
Safe NMN Dosage for Humans
Because NMN hasn’t undergone human trials, a safe dose for human consumption is not known.
Safety and efficacy studies must be conducted, followed by peer-reviewed, human clinical trials.
Currently, it is recommended that anyone seeking antiaging treatment should consult their physician before purchasing or taking an NMN.
On the other hand, NMN product labels recommend a daily, two pill or lozenge program taken before each meal.
A review of NMN products reveals that this is the most popular method of NMN consumption.
How Bioavailable is It?
The bioavailability of NMN is highly debatable. The issue is whether a sufficient dose could get through the gut without being changed by stomach acid. With this undesirable possibility in mind, various manufacturers have endeavored to make products that can survive passing through the stomach. Some manufacturers offer extended-release versions that designed to prolong and slow the absorption.
The study found :
absorption from the gut into blood circulation starts within 2–3 min and within 15 min, it is completely absorbed into tissue. Then it is converted and stored immediately as NAD+ in tissues like liver, skeletal muscle, and cortex. This increase in hepatic [liver] NAD+ content persists for about 30 min. After six months of molecule administration, this spiked concentration of NAD+ can be observed in the liver and brown adipose tissue, however, not in skeletal muscle and white adipose tissue
Is NMN the Same as Niacin?
Is Vitamin b3 the same as nicotinamide riboside?
Niacin, more commonly known as Vitamin B3, is the precursor to NMN. Therefore, Niacin is a more basic form of NMN.
Niacin has already been proven to have various health benefits, and it is inexpensive.
Human trials have previously been conducted on Niacin, proving that it is safe for consumption.
Furthermore, many experts predict that NMN treatment would be substantially more expensive than Niacin treatment.
However, it is a much more complex compound and may have several more benefits or consequences related to antiaging.
Human trials for NMN treatment are to be expected to take place in the coming years.
Doctors Best NMN Formula
Following several months of testing on mice, researchers report that mice fed a specific dose of the molecule NMN improved muscle strength, wound healing, and muscle recovery after trauma. The study, published online in Experimental Neurology, helps us understand how NMN improves the functioning of our mitochondria, the organelles within our cells that provide energy. This is important because studies have shown that mitochondria are responsible for many diseases, including Alzheimer’s, cancer, muscle diseases, diabetes, and aging. The mechanism behind NMN’s neuroprotective effect remains unclear. Researchers think NMN in the blood may induce changes in the activity of mitochondria inside our cells.
Numerous studies have shown that we have two mitochondria types in our cells – Type 1 and Type 2. Type 1 mitochondria are highly specialized for aerobic energy production. They specialize in producing adenosine triphosphate (ATP), a compound used by cells to power the energy of cells. Type 2 mitochondria specialize in oxidative metabolism, which is the process of breaking down the cell’s energy source, adenosine diphosphate (ADP). Previous studies have shown that metabolic dysfunction and aging increase the vulnerability of our cells to injury. But they have also shown that healthy mitochondria can produce ATP more quickly than Type 1 mitochondria. Scientists also discovered that restoring mitochondria function could be one of the most important ways to prevent neurodegeneration and other diseases.
What foods contain Nmn (natural food sources)?
Can Nmn Reverse Aging?
A study was conducted to determine if any of the natural substances such as alcohol, mushrooms, grapefruit, kombucha, kale, grape juice, green tea, blueberries, salmon, algae, goji berries, grass-fed meats, and bacteria and fungi, have any effects on the aging process. The antioxidant properties of some of these substances, like the blueberries, which are high in polyphenols, have been shown to slow the aging process, but none of the above-tested agents appeared to have a significant impact on the aging process.
Researchers conclude that none of the natural substances tested had an effect on the aging process and if the results are replicated in humans, they may become useful in the therapy of aging. Collagen is considered to be the most abundant protein in the body with over 40,000 amino acids, and the most abundant collagen in the body is found in blood vessels and skin. Researchers have discovered that the most prevalent protein in the body called fibroblast growth factor 23 (FGF-23) may have anti-aging properties.
Which is Better NMN or Niagen?
At this time, scientists have not found the answer to the question of which of the two is better for longevity. While both compounds have been shown to work, and both have their drawbacks, there are no definitive answers yet. According to Steve Stettler, a computational biologist and co-inventor of the RNAs mentioned above, it’s a tough call. It is a critical point,” said Stettler. “One potential advantage of NMN is that the pathway of choice is not realized by all of the available NMN. This may explain why people haven’t seen a strong impact on heart health or cognitive function with NMN.
But Nistel, the UCI associate professor, doesn’t buy this. NMN binds much more tightly to DNA than does Niagen,” he said. “That will affect certain pathways so that if you take more NMN, there will be more binding. However, the fact that Niagen does bind more tightly than NMN suggests that [the other compounds with double wood] are probably doing something bad to the DNA, too. Both Niagen and NAC are rapidly absorbed in the blood, making them potentially less toxic than caffeine, and studies have shown that their consumption in doses below the toxic level has few negative side effects.
What Age Should You Start Taking NMN?
As the Scientific American article points out, the process of turning fat into ketone bodies isn’t very efficient in adult humans, but the process can be enhanced and sped up. It’s for this reason that NMN supplements are now being marketed to the public in a way that avoids the very harsh effects of fasting, including liver damage.
It’s also worth noting that NMN doesn’t have any negative health effects to speak of – in fact, it seems to provide an added benefit to dieters. In one of the studies, obese subjects who were given NMN supplements for six months lost about 5% of their body weight. This is certainly a benefit for weight-conscious individuals, who don’t have to pay to be at the mercy of other diets and intermittent fasting.
Frequently Asked Questions
Does NMN Actually Work?
The effectiveness of NMN (Nicotinamide mononucleotide) is an area of active scientific research, and while initial findings are promising, further studies are needed to establish its efficacy definitively. NMN is a precursor to NAD+ (nicotinamide adenine dinucleotide), a coenzyme involved in various cellular processes, including energy metabolism and DNA repair.
Animal studies have shown that NMN supplementation can increase NAD+ levels, improve mitochondrial function, and potentially provide benefits in age-related conditions. However, human studies on NMN are limited, and the available evidence is preliminary.
Some small-scale human trials have demonstrated positive effects of NMN supplementation on certain markers associated with aging, such as blood pressure, insulin sensitivity, and exercise capacity. However, larger and longer-term studies are required to validate these findings and determine the full extent of NMN’s effects on human health.
As with any supplement, it is crucial to consult with a healthcare professional before taking NMN, especially considering potential interactions with medications or individual health conditions. Additionally, it’s important to obtain NMN from reputable sources, as quality control and purity standards vary among manufacturers.
Why Has NMN Been Banned?
In late 2022, the FDA prohibited the use of NMN as a dietary ingredient due to its past use as a drug and new studies on its medicinal properties.
However, it’s important to note that regulations and restrictions on the sale or marketing of NMN may vary between countries. Some regulatory bodies may have specific requirements or limitations on the labeling, advertising, or claims made about NMN products. These regulations are in place to ensure consumer safety, prevent misleading information, and maintain quality standards.
It is advisable to check the regulations and guidelines set by the relevant regulatory authorities in your country or region to understand any specific restrictions or requirements related to NMN. Additionally, consulting with a healthcare professional can provide personalized guidance on the appropriate and safe use of NMN or any other supplement.
Final Words on NMN Supplements
Alive By Nature and ProHealth NMN are great supplements made by reputable companies.
If you are interested in taking an NMN supplement, they are our recommendation.
Tru Niagen is certainly a better choice for a more studied and conclusive precursor to NAD+.
Whether you are buying off our list or looking at another supplement, you should always keep in mind the company’s reputation and its business practices.
***These statements have not been evaluated by the Food and Drug Administration. These products are not intended to diagnose, treat, cure, or prevent any disease. Individual results may vary.***