Elysium Basis Review

Elysium Basis Review (2020 Update) | Anti-Aging Miracle or SCAM?

IF you are reading this, you may already know that Nicotinamide Riboside is a relatively newly discovered NAD+ precursor.

Low NAD (nicotinamide adenine dinucleotide) levels in the body are shown to impair mitochondrial function.

Levels of NAD diminish as we age.

What is Elysium Basis?

Elysium supplement company founded by Leonard Guarente (MIT researcher and chief scientist) and tech investors Eric Marcotulli and Dan Alminana.

Elysium is Clinically-Proven NAD+ Supplement. NAD precursors found in Elysiumand TruNiagen products promise to replenish NAD levels in the blood and inside a cell.

Let’s find out if products from Elysium Health are the real fountain of youth or another over-hyped product?

We will also uncover some controversy behind its product.

MY RECOMMENDATION ( For Longevity & Daily Energy)
There are only a Few Leaders in this Market Segment ( . & .). . is the ONLY Legal Distributor. The product has thoroughly been Tested for Efficiency & Safety.

Much Anecdotal Evidence Pointing Out to Increased Energy Throughout The Day. I Can Confirm This In My Personal Experience. Also, Product Scientifically Proven to Increase NAD Levels. Now. (.).

  • 100+ Preclinical Studies
  • 20+ Owned and Licensed Patents
  • NIAGEN was successfully reviewed under the FDA’s (new dietary ingredient notification program (NDI)

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Is Nicotinamide Riboside Good / Health Benefits?

Nicotinamide Riboside, aka Niagen, is shown to slow the symptoms of the natural aging process in animal studies.

NR is one of the precursors of NAD+, which means it transforms into NAD+ inside our body. NAD+ found in a whole body.

This helper molecule increases your energy levels, your metabolism, and memory.

Nicotinamide RibosideBy taking NR, the alternative form of vitamin B3, you are betting on a fact that biological processes related to aging will improve.

DNA cells will be repaired, your immune system will work better, and your internal clock readjusted to ward off various sleep issues.

Many chronic illnesses are related to low NAD levels, including diabetes, heart issues, and Alzheimer’s, and NR supplements promise to help to raise NAD levels.

Even though you can find NR in some foods like cows’ milk and flour, NR supplements are more effective at elevating NAD levels. Read the following guide to find the best nad supplement.

Elysium Health Lawsuit

Chromadex and Elysium Health are fighting over the patents for the use of NR with hopes to reap the windfalls that come with controlling the market.

Elysium LogoNR is the main ingredient in Elysium Health, but this isn’t the only company that sells it.

However, its selling proposition revolves around the six Nobel Prize winners who have taken up an advisory role in this company.

While this should make the Basis more credible, the truth is that the six scientists and researchers aren’t actively involved in the creation of Elysium, nor the combination between NR and Pterostilbene.

This company doesn’t highlight the use of Niagen in its composition and markets Elysiumas an exclusive blend created by these scientists.

However, Elysium used to buy both NR and Pterostilbene from their competition, Chromadex.

Elysium Supplement Reviews / How Did This Start?

When dr. Brenner found out that NR can replenish NAD levels, Chromadex immediately went on board, promising to help manufacture and sell these health supplements.

Eventually, Chromadex couldn’t keep its promises, so Elysium got in the picture as one of Chromadex’sprimary customers.

Elysium started buying NR from Chromadex, which they used for manufacturing Elysium.

In 2017, Chromadex and Elysium Health started a lawsuit, after which Elysium started manufacturing its Nicotinamide Riboside.

Chromadex LogoThat’s why I think that Elysium is not more effective than other products that use NR, especially since most of these companies still buy NR from Chromadex.

The lawsuit revolves around the patent challenge, but Chromadex won this battle.

There are various lawsuits between these brands, with claims like patent misuse, fraudulent inducement, breach of contract, false advertising, and unfair competition.

Chromadex accused Elysium of plotting and scheming to get control over the NR market.

Elysium accused Chromadex of selling NR to another company for a lower price.

In my mind, it’s all about two giants fighting for market control on an anti-aging pill which already brings revenue of tens of millions of dollars. Basically, this lawsuit is about money.

Where Does Elysium Get Their Nicotinamide Riboside?

At first, Elysium got its Nicotinamide Riboside from Chromadex, like various other companies that sell NR-based products. However, they didn’t feature Niagen – Chromadex’s proprietary NR – on the Basis’s tag.

Following the 2017 lawsuit with Chromadex, Elysium lost the patent war and claimed they started manufacturing its own Nicotinamide Riboside.

This raises various questions. For instance, Basis endorsed by some clinical studies, but those were done with Chromadex’s Niagen.

Can the study results still stand if Elysium uses another substance?

Elysium Safe?

Besides, Niagen is an NR chloride, which explains its white color, stability, and long shelf life.

If Basis doesn’t use Chromadex’s Niagen, what accounts for its white color, stability, and shelf life? How is the new Basis produced? Is the new Elysium safe?

Elysium should come up to answers to all these questions. Besides, what if Elysium broke the patent infringement and still uses Niagen?

Another strong point is that Elysium claims that Basis is manufactured in the US – but doesn’t say where its ingredients are manufactured. That doesn’t sit right with me.

Do Nicotinamide Riboside Supplements Like Basis Work?

Some online reviewers claim to see an improvement in their energy levels, mental clarity, and sleep. I’ve taken some NR supplements, and I could see improvements in all those areas too.

However, some people say they didn’t notice anything after taking NR.

What Does the Science Say?

The current research revolves around the benefits of nicotinamide riboside and NAD on animals, with very few human studies to date.

That’s why we’re not talking about the benefits of NR and NAD+, but rather of their potential benefits.

The studies highlight that NR is the easiest to convert into NAD+, the coenzyme responsible for good aging. Other NAD precursors aren’t as easily absorbed in your body as NR.

NAD LevelsNR activates sirtuins, which help you age healthily. Various animal studies link sirtuins to improved life span and better health, better DNA repairs, improved stress resistance, and less inflammation.

Nicotinamide riboside could also protect brain cells because it’s involved in the synthesis of the PGC-1-alpha protein.

This protein acts as an antioxidant and activates when your body’s mitochondrial function backfires, which usually happens for patients with brain disorders like Alzheimer’s.

An improved mitochondrial function leads to more energy, but NR can also decrease the risk of heart disease. That’s because raised NAD+ levels stabilize blood pressure and make the aorta more flexible.

Other benefits include a more rapid weight loss, lower risk of cancer, better muscle function and even improving jet lag symptoms.

Needless to say that some scientist are critical about any claims such companies makes:

If you say you’re a terrific scientist and you have a treatment for long term healthy aging, it gets a lot of attention,” Jeffrey Flier pointed out, a former Harvard Medical School dean who has critisize the hype around this product.

What Are the Risks of Nicotinamide Riboside?

Various studies highlight that a dosage of a maximum of 2,000 mg daily has no harmful effects.

While the current research shows no side effects or adverse reactions to NR, these studies are short and feature few subjects.

Vitamin B3

Some online reviewers complain of nausea, tiredness, GI discomfort, and mild headaches after taking NR.

The good news is, unlike vitamin B3, NR doesn’t give you uncomfortable face flushes.

Elysium Basis Ingredients

Elysium supplement features 250 mg NR and 50 mg pterostilbene. The formula includes various thickeners and anti-caking agents which are generally safe, like Microcrystalline Cellulose, Hypromellose, Vegetable Magnesium Stearate, and Silica.

The 250 mg of NR has benefits for age-related illnesses. But I already discussed all that above.

What I want to focus on are those 50mg of Pterostilbene. This substance has recently been shown to increase bad cholesterol levels.

However, some companies still use it in their chemical formulas, especially products that claim to improve cognitive functions.

Elysium Basis supplement Ingredients

Pterostilbene has a similar composition to Resveratrol, that magical molecule in grape skin which is supposed to make you younger.

According to Elysium Health, Pterostilbene protects against cellular stress, has various anti-aging properties, and activates the sirtuins we talked about before.

That’s why this substance can increase your metabolism and help you lose weight faster.

So, would I take a product that contains Pterostilbene? That depends. I took Pterostilbene before it was proven to influence bad cholesterol.

Though I saw it works, I wouldn’t take it again – anyway, not until I would talk to my GP about it.

Nicotinamide Adenine Dinucleotide (NAD+) & Your Health

NAD+ has a significant influence on human cellular health and health in general. Decreased NAD levels impair mitochondrial function, which happens as we age.

Mitochondria are the powerhouse of your cell. So if they don’t work properly, your energy levels decline.

That doesn’t just mean you’ll feel more sluggish.

But a body with decreased energy levels has less power to fight infections and to heal itself.

That’s why age-related declining NADlevels link to an increased risk of chronic illness.

NAD PlusIn turn, NAD+ helps you age gracefully and feel more energetic.

There is plenty of research revolving around NAD, and the fact that it can alleviate symptoms of Alzheimer’s, diabetes, and cancer.

A study published in Cell Journal shows that NAD precursors help rejuvenate mitochondria in mice.

Various animal clinical trials emphasize convincing results in terms of increased cellular energy. This helps your body repair your DNA, so it works better.

NAD+ is involved in the creation of sirtuins. These proteins are NAD+-dependent deacetylases, which improve your metabolism, regulate your circadian rhythm, or how your body adapts to day-night changes, plus they repair your DNA and reduce inflammation.

Sirtuins have various cardiometabolic benefits. They protect against obesity, improve your blood circulation, heart issues, and regulate insulin sensitivity. Most of these disorders connect to old age and a sedentary lifestyle.

NAD is also involved in treatingCockayne syndrome. This genetic disease is rare and appears in children, who get symptoms of old age.

Seeing as NAD can effectively treat these symptoms, it’s believed that it can improve age-related issues in adults too.

Elysium Basis vs.Tru Niagen

I’ll start with the short version: Tru Niagen is better because it has an original formula, quality ingredients, and a better price.

Although Basis and Niagen both contain the same primary active ingredient – NR – there are significant differences in the companies’ product, pricing, and service. Also, Tru Niagen now contains 300mg of NR/ dosage, whereas Basis contains 250mg.

Versus Tru NiagenAnother point to consider is that Chromadex stopped using pterostilbene in its products after the new research shows it increases LDL – bad cholesterol.

Elysium has other ingredients that stop me from taking it, such as trace residue of toluene. The opinions are split regarding toluene, especially considering that it’s not toxic enough to manifest severe adverse reactions.

The bigger problem, however, is that Elysium didn’t tell the FDA (Food and Drug Administration) that it’s using toluene in its manufacturing process from the start.

True Niagen is a better product because it uses quality ingredients. The capsules are vegetarian, with no added gluten, caffeine, nuts, or artificial ingredients. Besides, Tru Niagen is FDA-certified, whereas Elysium is not.

There’s a lot of science backing TruNiagen, published in peer-reviewed magazines.

TruNiagenThese clinical trials are based on various other pre-clinical studies at famous US and worldwide universities, as you can see from the Chromadex website.

Besides, Chromadex has 20 licensed patents for its product and over 140 research collaboration with famous US universities.

This propensity for research shows that Chromadex is working hard to improve the TruNiagen formula.

On the other hand, the studies featured on Elysium’s website are less convincing.

Firstly, the ones relating to the benefits of pterostilbene are short and involve fewer participants.

The ones which show how NR works are problematic too, seeing as Elysium manufactures NR on its own, and doesn’t disclose anything about the manufacturing process.

Regarding the price, Elysium needs you to subscribe so you can benefit from its discounts.

TruNiagen features both a subscription discount and a multi-bottle discount so that the price decrease can be up to 40%.

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How Much Does Basis by Elysium Cost?

One bottle of Elysium costs $60, while six bottles cost $270.

Various discounts are depending on your purchase plan, though. With one year of prepaid deliveries, you can save up to 33%.

Elysium Health Index Biological Age Test Review

The index is a home test intended to determine based on epigenetics how fast consumers have continued aging. Elysium Health presents a combined speed of aging and biological age in the report. The overall biological age is intended to show how a c client’s overall health would equate to a person of normal health at the same age. The examination looks for DNA methylation (a straightforward method that points to suppress gene transcription) in a client’s genome. While methylation isn’t the unique epigenetic change to happen, it is simple and matches closely with other age-related biomarkers.

lifestyle, Genetic,  environmental, and transient factors may affect DNA methylation. Lifestyle choices include diet fitness, smoking, etc. Simultaneously with the increasing rate of aging and overall biological age, the Index paper presents advice on how buyers can improve biological age through simple lifestyle changes. The product is not meant to diagnose, treat, cure, or prevent any disease or condition or evaluate the risk of any condition or disease.

The Index Science

Epigenetics is separate from genetics. Most DNA Tests, like those purchased from Ancestry, 23andMe, investigate the underlying genetic principles. This code gives insights into things such as health-related choices, ancestry, and character traits. The genome is fixed.

Epigenetics includes differences affected by changes that turn genes off and on and not the code. Eventually, epigenetic modifications control cellular action. Unlike the static genome, epigenetics is dynamic during life.

Professor at Yale School of Medicine Morgan Levine, Ph.D.,  was vital in the creating of Index. Today, the investigation is powered by the proprietary Elysium Health chip, produced in conjunction with Illumina. The chip uses the APEX – Algorithmic Platform for Epigenetic Examination to evaluate and examine epigenetics from a saliva specimen.

Conclusion

That said, Elysium Health has lots of things to change, starting with its transparency. The pterostilbene in its composition is debatable, although you can talk to your GP about it.

The NR proportion is still reasonable, albeit not as good as that offered by its competitor company Tru Niagen.

Tru Niagen BetterIf the company were open about its manufacturing process and where it gets the nicotinamide riboside, Elysium Basis would be a product I could get behind. It doesn’t help that you have to pay more for it either.

This money is supposed to account for the pterostilbene and the six Nobel scientists in the scientific advisory
board, but they’re not endorsing Elysium supplements – they simply act as consultants.

Elysium, on the other hand, tries to make them seem actively involved in the creation of its NR, which is just false advertising.

So things being as they are, TruNiagen is always a better option for me. The price and discounts are way better too.

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Rhonda Patrick Supplements

Dr Rhonda Patrick Supplements List (2020) | Health & Longevity!

The following review, research is on what supplements Dr. Rhonda Patrick’s is taking for energy and longevity.

Her work on daily health and longevity and also applies to ApoE4 gene carriers.

ApoE4 carriers are estimated to make up about 20% of the total population.

A genetic test is needed to find out if someone carries the ApoE4 allele; this is most commonly performed with a saliva test.

Dr. Rhonda PatrickTwo of the most common good source/sources for this testing are popular genetic testing websites like 23andme or ancestry.com.

The exact number of people who carry the ApoE4 allele is currently unknown.

However, Dr. Rhonda Patrick’s studies estimate that it’s around 25% of the population.

On the other hand, the sample size of Rhonda’s paper may not be large enough to draw strong conclusions on this.

Dr. Rhonda Patrick is one of the leading researchers in the field of longevity.

She currently runs a podcast, during which she discusses the topic at length. Additionally, she has discussed these topics on other podcasts and interviews.

Below is a high-level overview of Dr Rhonda Patrick’s supplements & Brands that she is recommending!

Dr. Rhonda Patrick’s Supplement List

To begin this review, here is an overview of Dr. Rhonda’s supplement list.

Dr Patrick’s Daily Supplements Recommendations

All list bellow great to strengthen your immune function:

  • Multivitamin – Pure Encapsulations O.N.E: One capsule daily (.)
  • Vitamin D3 – Thorne Research: Two capsules daily (.)
  • Vitamin K2 – Thorne Research K2/D3 Drops: One drop every two to three days
  • Fish Oil – Norwegian PURE-3 DHA: Six capsules daily
  • Omega-3 Phospholipids Four capsules daily (.)
  • Magnesium – Thorne Research: One capsule daily (.)

ADDITIONAL SUPPLEMENTS THAT DR. RHONDA USES AND RECOMMENDS

  • Nicotinamide Riboside: Works to increase cellular mitochondrial function (.)
  • PQQ (Pyrroloquinoline Quinone): Used to increase cognitive ability temporarily (.)
  • Curcumin Phytosome: Works as a natural anti-inflammatory, which can be used as an alternative to ibuprofen
  • Probiotics: Helps improve the health of bacteria in the abdomen
  • Hydrolyzed Collagen (Great Lakes): Improves health in the skin and joints

DR. RHONDA’S PREFERRED LIST OF NOOTROPICS

  • Choline: Improves mental acuity and brain health
  • Lion’s Mane Mushroom: Should be used especially for intense periods of cognitive function (e.g., difficult or intense work)
  • Sulforaphane: Derived from broccoli sprouts. It has been linked to improved heart health and digestions.

ADDITIONAL RECOMMENDATIONS

    • Beet Powder – For individuals with high blood pressure (activz organic beet powder brand)
    • Wild Salmon Roe Caviar –  Organic source of DHA and EPA phospholipids
    • MelatoninRhonda Patrick doesn’t supplement with melatonin, but she does suggest this as a strategy if you’re someone over 50 years of age (natural melatonin production goes down ), or if you have problem sleeping. Rhonda has recommended Life Extension brand

Few Other Mentions:

Resveratrol – Rhonda invited David Sinclair on her podcast and they were discussing the effects of Resveratrol. Since that time, she has posted a review of Resveratrol on her site. In her recent AMA (Ask Me Anything) discussion, she mentioned Resveratrol and saying that she doesn’t currently take it, but is considering this option in the future.

Coconut Milk – she mentioned that the reason she like coconut milk in her smoothies, rather than regular milk, is because milk has salivary proteins that bind to polyphenols and anthocyanins which limits their bioavailability.

Methylated B VitaminsSwanson’s B Complex – Rhonda has recommended to family and to someone with MTHFR mutation

Metformin – Metformin has been extensively examined in humans for a few decades now. It is prescribed to be taken to fight type 2 diabetes. IIT become popular amongst enthusiasts to extend lifespan and healthspan.  In a podcast with Kevin Rose, Rhonda talks about the metformin use for lifespan extension. There is evidence is responsible for inhibiting lean muscle mass growth while on an exercise program, in comparison to placebo,

She mentioned that workout and exercise are more helpful at type 2 diabetes prevention than metformin by referring to a randomized controlled trial. She also challenges the metformin value for a healthy person who regularly exercises regularly.

Health & Longevity Supplement List

NICOTINAMIDE RIBOSIDE

Nicotinamide Riboside (NR) is a recently discovered variation of vitamin B3.

Nicotinamide Riboside +

NR works by increasing the amount of (NAD+) in the body.

NAD+ is a critical enzyme that is used within the mitochondria of every cell.

Aging, disease, and chronic inflammation naturally decrease the levels of NAD+ in our bodies.

The objective of this supplement to increase the amount of NR in the body, which will in turn increase NAD+.

As an added benefit, this should make your tissues, organs, and muscles function the way that they would in a younger person.

So far no exact recommendation Rhonda Patrick making in NAD Brand, but I am personally taking True Niagen duet to various research available and people behind the brand. Read my True Niagen Review.

MERIVA

This supplement can be used as an anti-inflammatory and substituted for more common medications like ibuprofen.

There is no debating that ibuprofen is effective against inflammation and pain relief.

However, long term use of ibuprofen has been known to produce undesirable side effects.

Dr. Rhonda’s goal for substituting the supplement in place of a drug like ibuprofen is to enable long term use without the risks.

Meriva SFAdditionally, this supplement can be made from turmeric root, which is comprised of an organic substance called curcumin.

In order to create the supplement, curcumin must be removed from the turmeric root and then concentrated.

The curcumin is mixed into a phospholipid to improve absorption and retention by our bodies.

The method by which this supplement decreases inflammation is unique.

Inflammation is an evolutionary survival mechanism that has been essential for humans. It assists us in fighting illness and healing injuries.

On the other hand, high inflammation, or swelling in places where it should not be, can be problematic or a sign of another problem.

The cytokine is a type of protein found in humans; its function is to monitor cell signals.

These cell signals increase or decrease swelling.

Meriva SF Supplement FactsWhen cytokines have a problem with regulating inflammation levels, the result can be unnecessary inflammation.

Curcumin can delay or stop these problems by regulating inflammation in cytokines.

There are additional uses and benefits to using the supplement.

Dr. Rhonda mixes organic turmeric into her smoothies, which is a tasty and easy method of adding the supplement to your diet plan.

Recent research has indicated that curcumin increased memory ability in elderly people who complained of mild memory issues.

The group that received the curcumin showed a twenty-eight percent increase in a specific set of cognitive functions.

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PROBIOTICS

Dr. Rhonda never fails to emphasize how critical it is to maintain the health of the gut microbiome.

Probiotics Are USefulShe takes probiotics every one to two weeks, which are beneficial to the health of abdomen bacteria.

Probiotics should only be used to supplement the benefits of a healthy diet plan.

They cannot be used exclusively to maintain the health of gut bacteria.

Probiotics can also be useful during pregnancy.

Research has shown that mothers who use probiotics during late-stage pregnancy and nursing had less inflammatory biomarkers.

HYDROLYZED COLLAGEN

Dr. Rhonda has been advocating for the use of hydrolyzed collagen powder for several years as anti-aging supplement.

She adds the hydrolyzed collagen into her daily diet by mixing it into smoothies and other drinks, which is similar to the method much use with curcumin.

Collagen Hydrolysate Great LakesShe initially became interested in hydrolyzed collagen because of a research study that showed peptides in hydrolyzed collagen could be beneficial to joint health.

Recent research has helped gain Dr. Rhonda’s interest in hydrolyzed collagen.

A recent study included 26 healthy participants that showed various signs of aging.

They were given a daily supplement of one gram of collagen powder over twelve weeks.

The result of the twelve-week supplement program was a 76% decrease of dry skin and scaling as well as a 13% decrease in facial wrinkles and lines.

Furthermore, participants experienced an 18% improvement in the composition of hemoglobin in their dermis.

These results indicate better microcirculation of the blood.

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PQQ (PYRROLOQUINOLINE QUINONE)

Recently, Dr. Rhonda has advocated for the use of pyrroloquinoline quinone (PQQ).

PQQ Caps 20mgA 2006 Japanese study showed that PQQ increases neurological function, which was measured by the Stroop cognitive test.

Researchers surmised that PQQ increases cognitive function by improving the blood flow as well as oxygen metabolism in the right prefrontal cortex.

These findings are particularly encouraging because PQQ is naturally created in the body.

Therefore, utilizing PQQ does not involve adding a foreign substance to your diet.

However, the overall effectiveness of PQQ remains mostly unknown.

Additional research must be conducted to determine its specific effects on cognitive function.

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Cocoa Extract

Rhonda suggested using cocoa flavanol supplement a while back and then more recently discussed it in her May 2020 podcast.

She mentioned that she’s getting Two capsules of CococaVia every day, especially in the morning, due to it’s a small amount of caffeine. She remarks that she has no connection with this particular brand.

She quotes Three possible benefits of cocoa flavanols – enhanced cognition, increased circulation, and changes to the skin (wrinkle reduction and improved skin elasticity).

Research that she mentions to enhanced circulation:

  • Dark (85% cocoa), and not milk chocolate, increased walking ability in aged subjects with peripheral artery disease
  • Cocoa reduced blood pressure in healthy people, in a dose-dependent fashion
  • Heighten strength performance in male cyclists who ate dark chocolate – showing a performance improvement of around 17% vs eating the white chocolate

Rhonda Patrick’s Dietary Nootropic Supplement Stack

Nootropics are substances, supplements, and drugs that are thought to improve neurological ability.

They are particularly useful with the brain’s executive functions, which include memory, creativity, and motivation.

Dr. Rhonda has two main criteria that she uses when evaluating the safety of a nootropic supplement.

  1. Avoid nootropic supplements that lower enzyme levels.
  2. Do not use nootropic compounds that are not natural. These criteria were added because newer nootropic supplements have not been studied under enough scrutiny to understand the effects on cognitive function fully.

Here are the three main nootropic supplements that Dr. Rhonda uses and recommends for followers.

LION’S MANE MUSHROOM

Lion’s Mane mushroom is commonly used for its positive neurological effects.

Research has shown that the supplement can improve certain cognitive functions.

Lion's Mane Four Sigmatic

Additional research on Lion’s Mane mushroom suggested that it was effective in improving neurological deficiencies within a group of 30 adults who were between ages 50 and 80.

The participants used 3 grams of Lion’s Mane powder per day for a period of 16 weeks.

The participants were tested at weeks 8, 12, and 16 of the study.

At these testing marks, they demonstrated significantly higher levels of neurological function when compared to the placebo control group.

The participants were tested again 4 weeks after ceasing their use of Lion’s Mane powder.

Those test results showed significantly decreased scores for neurological function.

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SULFORAPHANE SUPPLEMENT

Sulforaphane is a product of a mixture of glucoraphanin & myrosinase. Glucoraphanin is derived from plants and is a phytonutrient.

Additionally, glucoraphanin brings on a beneficial hormetic effect in humans.

SulforaphaneWhen humans consume sulforaphane, it activates the NRF2 pathway of the brain.

The NRF2 pathway improves the expression of several protective cell genes.

These findings come from an incredible study, which also indicates there are even more benefits of NRF2.

Sulforaphane continues to be the center of a wide variety of research.

The current findings indicate that it has a potential role in extending lives, preventing cancer, and additional health benefits. Jed Fahey of John Hopkins University, one of the best researchers in the area of sulforaphane/NRF2, reminds us to be mindful of which supplement brand to use.

Prostaphane from a  French manufacturer seems to be the best option but is not available in the US as of now.

RETRIEVING SULFORAPHANE FROM BROCCOLI SPROUTS

Dr. Rhonda obtains sulforaphane mainly through growing broccoli sprouts.

Additionally, she will use another supplement as a fail-safe when she does not have enough broccoli sprouts, or her crop fails.

Broccoli sprouts are simple to grow, and Dr. Rhonda shares her growing setup with her followers.

Here are the things you will need to grow broccoli sprouts effectively:

  • Ball Mason Jars
  • Sprouter Lids
  • Natural Broccoli Sprout Seeds

Dr. Rhonda harvests her broccoli seeds every three days; research that suggests young sprouts possess increased glucoraphanin compared to older sprouts.

CHOLINE – ALPHA GPC

In a 2017 Tim Ferriss podcast, Rhonda talked about the Three nootropics that she likes and approves. Nootropics are drugs that have the potential to improve cognitive function such as memory, concentration, memory & alertness.

Dr. Rhonda has stated that she consumes Choline supplements in rare instances.

Alpha GPC 300MgThese instances are usually when she must complete a large amount of writing or if there is an event where she will be speaking.

She states that Choline supplements improve her cognitive function.

Dr. Rhonda emphasizes the importance of including organic sources of choline in the diet.

Natural sources of choline include eggs, chicken, broccoli, spinach, and almonds.

Several types of choline supplements can be consumed.

Dr. Rhonda suggests using Alpha GPC because it can cross the blood-brain barrier with ease.

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Which Supplements Does Dr. Rhonda Patrick Take on a Daily Basis?

Dr. Rhonda has selected a few supplements that she advocates for using daily, which she also uses in her diet.

MULTIVITAMIN

Pure O.N.E. Multivitamin

  • Pure Encapsulations O.N.E. –  One capsule daily

Dr. Rhonda takes the Pure Encapsulations O.N.E. multivitamin.

It’s comprised of a broad spectrum of critical micronutrients and contains doses of the essential ones.

Rhonda Patrick Vitamin D Choice – Thorne Vitamin D3

Throne D3 Vitamin

  • Thorne Research – D3 (1,000iu): Two capsules daily

Dr. Rhonda sees vitamin D consumption as vital to remaining happy and healthy.

Vitamin D levels play an essential role in serotonin control.

D-1000 FactsSerotonin controls several executive function features, such as sensory gating and social behavior.

It’s fundamental to consider the amount you take, however.

Consuming too much vitamin D can be harmful while taking too little of it is just as bad.

Finding the correct amount for you is critical to your diet.

The amount of vitamin D that each person should consume is variable and depends on numerous factors. Some of these factors include:

  • Diet
  • Sun exposure
  • Body composition
  • Blood composition

VITAMIN K2

Vitamin D/K2

  • Thorne Research K2/D3 Drops: One drop every two to three days (1 capsule, 3 times per week)

Vitamin K is essential for the body to produce proteins that encourage blood coagulation. Additionally, it is used in the transportation of calcium for bones and other tissue.

Dr. Rhonda consumes vitamin K2 through the addition of leafy green vegetables to her diet, as well as a lot of vitamin K1.

The supplementation of vitamin K2 acts as a fail-safe in case she is not getting enough vitamin K1.

Low levels of vitamin K can eventually lead to increased blood pressure and risk of stroke.

Dr Rhonda Patrick Fish Oil Choice – Norvegian Pure

Omega 3 Fish Oil

Omega-3s, EPA, and DHA are critical fatty acids.

More precisely, these fatty acids are scattered into cell membranes throughout the body, but the most concentrated in the brain and eyes.

These fatty acids are essential to the mediation of lipids, which can have positive effects and help prevent several diseases.

Furthermore, fatty acids are critical for fetal development and aging.

On her last Joe Rogan Experience podcast, Rhonda mentioned she consumes 6 capsules of n-pure DHA now.

Prior to this, she was taking the Nordic Naturals a before that – omega-3 phospholipids via NOW Neptune Krill Oil.

OMEGA-3 PHOSPHOLIPIDS

Ikura Salmon Caviar

Dr. Rhonda currently takes her omega-3 phospholipids through Wild Salmon Roe Caviar.

She has made this selection instead of using supplements because the Wild Salmon Roe Caviar is a more organic option.

See this Instagram post and this here where she is talking more about caviar.

Rhonda Patrick Salmon Roe Caviar (Wild)- Vital choice Brand

MAGNESIUM

Throne Research CitraMate

  • Thorne Research – Magnesium Citramate: One capsule daily

Magnesium can be naturally found in leafy green vegetables.

Specifically, magnesium forms a portion of the chlorophyll molecule, which is partially responsible for photosynthesis.

If you see vegetables with a dark green color, they are sure to contain a concentration of magnesium.

Despite it being so natural and widely available, research indicates that roughly 50% of the US population has low or deficient magnesium levels.

Rhonda’s Pregnancy & Breastfeeding Supplement Regimen

Dr. Rhonda has been kind enough to provide a pregnancy and breastfeeding supplement regimen, which is much different from her standard day-to-day regimen.

Breastfeeding Supplement Regimen

The pregnancy regimen is the same for the first and second trimesters; it changes in the third trimester. It is important to recognize that the breastfeeding supplement regimen is separate from the pregnancy regimen.

FIRST AND SECOND TRIMESTERS

Dr. Rhonda’s daily supplement regimen is comprised of supplements that have yet to be researched or studied on women who are pregnant.

Moreover, Dr. Rhonda will not leave anything to chance when it comes to pregnancy, so those supplements are not included in the pregnancy regimen.

Here is Dr. Rhonda’s supplement regimen for the first and second trimesters.

  • Multivitamin: Three capsules daily
  • Fish Oil: Five capsules daily
  • Vitamin D: Two capsules daily

THIRD TRIMESTER

Here is Dr. Rhonda’s supplement regimen for the third trimester.

As you can see, the multivitamin, fish oil, and vitamin D supplements are the same as the first and second-trimester regimen.

Dr. Rhonda adds a probiotic and possibly an iron supplement for the third trimester.

As a note, the iron supplement should only be used if blood tests indicate low iron levels.

  • Multivitamin: Three capsules daily
  • Fish Oil: Five capsules daily
  • Vitamin D: Two capsules daily
  • Probiotic: One sachet daily
  • Iron Supplement: Not necessary unless blood tests indicate low iron levels

BREASTFEEDING SUPPLEMENT REGIMEN

Research has indicated that pregnant and breastfeeding women need higher amounts of specific nutrients compared to non-pregnant women.

The following list is Dr. Rhonda’s breastfeeding supplement regimen.

  • Multivitamin: Three capsules daily
  • Fish Oil: Five capsules daily
  • Probiotic: One sachet daily
  • Vitamin D: Five capsules daily
  • PQQ: One capsule daily
  • Vitamin K2: One drop every two to three days

Rhonda Patrick Multivitamin (Prenatal)

Basic Prenatal Throne

Research has indicated that pregnant women who are given a multivitamin supplement starting in the first trimester of pregnancy had children with higher IQ and verbal comprehension index scores.

These results were compared to women in a control group who did not receive the multivitamin supplement and whose children did not display the same cognitive improvements.

The research study responsible for these findings was conducted in a largely unpopulated area of China.

Basic Prenatal Supplement Facts

It is possible that the participants lacked nutrients before the start of the study; this could be why the treatment had a significant effect on their children’s IQ.

However, there are plenty of areas throughout the world with people who have low or deficient levels of nutrients.

The findings from this study are significant because it still conclusively demonstrates the importance of multivitamin nutrients on fetal development.

Dr. Rhonda selected this multivitamin because it has some critical benefits:

  • Increased folic acid decreases the likelihood of children born with spinal cord defects
  • Basic prenatal utilizes optimal levels of iron and iron bisglycinate
  • Contains several critical ingredients
  • Does not contain any unnatural ingredients

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How Rhonda Chooses Supplement Brands

The vitamin and supplement industry is surprisingly unregulated and lacking a unified approval structure.

It is especially surprising considering how strict and regulated the United States FDA is when approving food and medicine.

FDAOne would assume that the FDA would enact similar approval regulations for supplements and vitamins.

Dr. Rhonda recommends that individuals purchase supplements and vitamins that are approved by the NSF.

The NSF’s job is to independently evaluate and approve the certification of supplements.

This process is in place to ensure that supplements are not comprised of unlisted ingredients, contaminants, or other harmful elements.

The NSF employs rigorous and strict approval methods. Therefore, NSF certification is an ideal guideline to use when shopping for a supplement.

Final Words

Dr. Rhonda Patrick obtained her Ph.D. in biomedical science from the University of Tennessee Health Science Center in Memphis, Tennessee.

Additionally, Dr. Rhonda graduated with a Bachelor of Science degree in biochemistry and chemistry from the University of California in San Diego.

Rhonda PatrickShe has been involved in a wide variety of research on aging, cancer, nutrition, and longevity.

Later in her career, she completed research on aging at the Salk Institute for Biological Sciences.

This research was designed to figure out the role that insulin signals play in protein misfolding. Protein misfolding is often discovered in neurodegenerative diseases.

Dr. Rhonda often speaks to the public on topics such as micronutrient deficiencies in aging, as well as genetics related to the effects of nutrients on a person’s health.

Additionally, she has studied the benefits of introducing hormetic stressors to the body, such as through exercise, dieting, and multiple varieties of cold exposure. Finally, she has studied the significance of mindfulness, stress reduction, and sleep.

Dr. Rhonda’s primary objective is to challenge people’s old ways of thinking. Additionally, she would like to encourage people to think about longevity and health, and utilizing a preventative approach.

References:

1. Oral administration of (14)C labeled gelatin hydrolysate leads to an accumulation of radioactivity in cartilage of mice https://www.ncbi.nlm.nih.gov/pubmed/10498764

2. Effect of the Antioxidant Supplement Pyrroloquinoline Quinone Disodium Salt (BioPQQ™) on Cognitive Functions https://www.ncbi.nlm.nih.gov/pubmed/26782228

NMN Supplement Review

Best NMN Supplement (2020 Review) | #1 Best Anti-Aging Alternative?

In the last few years, there have been significant breakthroughs in the field of longevity and anti-aging. NDA+ research field attracted key scientists who been looking for to unlock cell rejuvenation.

There are two precursors to NDA+ that are talked about in the supplement community the most:

  • NR, or nicotinamide riboside
  • NMN, or nicotinamide mononucleotide

NMNI wanted to take a look more into NMN to see if it is as effective as taking NR supplement does for increasing NDA+ levels naturally.

People around the world spend billions of dollars on anti-aging products annually. The most common reason that people use these products is to reverse signs of aging (skin & body)!

Today, there is constant pressure to appear younger. Recent research into NDA+ shows promising results in not only reversing the appearance of aging but also in healing tissue on a cellular level.

This review is going to go over the top NMN supplements, what they do to your body, and if they are worth your attention & investment. After that, I will talk about research and science!

RECOMMENDATION ( For Longevity & Daily Energy)
Even David Express His Doubt  Regarding NMN Effectiveness. He Mentioned on a Podcast  That Nicotinamide Riboside May Do The Job Better and That is Where . Comes In.

There are only a Few Leaders in this Market Segment ( . & .). . is the ONLY Legal Distributor. The product has been Tested for Safety & Efficiency.

According to Anecdotal Evidence & In My Personal Experience – It Provides Energy Boost Throughout The Day & Scientifically Shown to Increase NAD Levels. Now. (.).

  • 100+ Preclinical Studies
  • 20+ Owned and Licensed Patents
  • NIAGEN was successfully reviewed under the FDA’s new dietary ingredient notification program (NDI)

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Top-Rated & Best NMN Supplement Brands

There is a wide variety of NMN supplement brands, which are produced by dietary supplement companies. Some products on the market are ineffective or provided by companies that are not trustworthy.

We took an in-depth look at three of the top-rated NMN supplement brands.

ALIVE BY NATURE SUBLINGUAL PURE NMN / Review

Alive by Nature

Alive By Nature’s pure NMN is a sublingual, fast dissolving tablet. By making the tablet sublingual, the supplement can be absorbed quickly into the blood vessels under the tongue.

This NMN has a low PH and lower molecular weight for better balance and faster delivery. The tablets give 125mg of NMN and are sweetened with monk fruit extract. They are vegan, keto-friendly, and GMO-free.

The company Alive By Nature is a newer company, but they adhere to strict regulations and standards. If you are looking to try NMN powder in your supplement routine, this may be an excellent choice. It’s attractive to want to save cash, but with NMN exactly, you receive what you pay for. Lower cost NMN will probably be the food-grade products, not pharmaceutical grade.

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PROHEALTH NMN Supplement

NMN Pro Health

ProHealth offers a lozenge form of NMN. Each lozenge contains150 mg of NMN, xylitol, and natural lemon flavoring.

They are all-natural, keto-friendly, non-GMO, vegan, and free of soy, and artificial colors or flavors.

The company triple tests this supplement to guarantee potency and purity. In the lozenge form, the NMN is thought to be more bioavailable.

This company has been making supplements for over 30 years. ProHealth is a trusted brand with a reputation for supplying clean, efficient, and reliable supplements.

If you are looking for an NMN brand that you can trust, this might be a good choice. The only drawback is the inclusion of xylitol, sugar alcohol, that makes these lozenges sugar free. Some people may have a laxative effect from ingesting sugar alcohols.

MAAC10 – 125MG

Maac10 125 Mg

Maac10 offers a bottle of 125 mg NMN capsules. They claim that this product is 99% pure NMN and also contains a newly discovered NMN transporter called Slc12a8.

Unlike other NMN supplements, this company opted for capsules to be swallowed and absorbed in the digestive system.

According to the site Fake Spot; this product received a C score for accurate reviews.

The feedback of the site is disconcerting for many in the supplement industry because it implies that they paid for good reviews.

Many of them may be fake, and deception may be involved. If this is true, it should dissuade buyers from purchasing from this company.

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Quicksilver NAD+ Gold Liposomal

The Quicksilver supplement is called Quicksilver NAD+ Gold. This is the only product from our list that delivers NMN in a form of liposomal.  Dr. Christopher Shade, Ph.D. mentioned that liposomal NMN possibly more bioavailable than NMN in a powder form. It also comprises of 50 mg of betaine (TMG) to help support methylation.

  • The brand has been around for years
  • Products are examined for Potency, COA, Potency, Heavy Metals,  Particle Sizing, and Ingredient Purity
  • Good customer service. Also available at their physical location, You can call their customer support line or send a support email

AN ALTERNATIVE TO NMN

Tru Niagen

Tru Niagen is a suitable alternative if NMN supplements aren’t right for you. Tru Niagen works by restoring the body’s NAD+ levels.

There are a variety of reasons that Tru Niagen is the top option for someone who is seeking rejuvenation treatment. It has been proven to have health benefits through plenty of research and studies. Some of those health benefits include:

  • Daily improvement of cellular health
  • Maintain healthy NAD+ levels throughout the body
  • Long-lasting beneficial effects
  • Increased energy levels

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Tru Niagen is manufactured and distributed by ChromaDex. ChromaDex is a leading nutraceutical and biotech company, whose aim is to improve people’s health and livelihood.

Dr. Charles Brenner leads the ChromaDex Scientific Advisory Board. Dr. Brenner is a brilliant scientist who first discovered nicotinamide riboside as a vitamin. Therefore, ChromaDex is continuously at the forefront of NAD+ research and development.

  • Human Clinical Trials – At this stage, there have been no human clinical trials conducted on NMN. Tru Niagen has undergone four separate clinical trials, which were peer-reviewed and published in scholarly journals.
  • Quality Reviews – Tru Niagen is approved as a Natural Health Product (NHP) by the organization Health Canada.
  • Research Collaborations – Tru Niagen has undergone over one-hundred and sixty independent research studies.
  • Over Seven Patents – ChromaDex, the producer of Tru Niagen, boasts a significant collection of patents.

NMN Supplement Research and Science

After significant breakthroughs in the studies conducted by Dr David Sinclair on NDA+ and its precursors, many companies and scientists began piggybacking off of the initial research.

Dr. Sinclair is the leading investigator for NMN being used as a booster for NAD+ and as a rejuvenation supplement.

He has focused on the possible links between sirtuins, resveratrol, NAD (nicotinamide adenine dinucleotide), NMN, rejuvenation products, and calorie restriction throughout most of his career.

NMN Science And ResearchDr. Samuel Klein from the Washington University School of Medicine in St. Louis conducted a study that was aimed at looking into NMN’s rejuvenation properties.

This clinical trial represents encouraging progress for NMN powder and anti-aging research; it illustrates that other members of the scientific community believe in the possible benefits of the NMN enzyme.

Professor Sinclair’s research indicates that by increasing NAD, damage to the DNA can be reversed. This finding was mainly illustrated by research that used NAD+ in elderly mice.

The NAD boost changed the tissue and appearance of elderly mice into those resembling much younger mice.

NAD+ ALSO REJUVENATES THE BODIES OF MICE

Sinclair’s earlier research has shown that NAD+ improved the tissue of mice on a cellular level.

These findings were incredible and unexpected; they sent a shockwave through the scientific community.

NAD+ CompoundThe mice that were given an oral NAD+ supplement compound regrew full coats of hair, had improved kidney function and were able to run faster than before. Additionally, the mice that were treated with NAD+ had improved muscle mass and tone.

In these respects, they appeared to be similar to significantly younger mice.

Similar studies have been done to identify the methods of rejuvenation in mice and aim to apply those methods to humans.

The growing amount of interest and research shows that scientists may be close to finding a definitive link.

WHY DNA REPAIR DECLINES WITH AGE

According to research by Dr. Sinclair and his team, they found that the protein DBC1 would latch on to a separate protein that helps repair damaged DNA.

As we age, the NAD+ in our bodies decreases, causing tissue damage and cell death. Research has shown that NAD+ treatment could stop DBC1 from inhibiting DNA repair.

This research is one of Dr. Sinclair’s most important career achievements. After the discovery of NAD’s effect on the DBC1 protein, Sinclair’s team knew that it was possible to reverse DNA damage.

DNA DAMAGE

DNA damage is a major source of common diseases related to aging, such as cancer, diabetes, heart disease, Alzheimer’s, and other cognitive disorders.

DNA CodeOur bodies possess an ability to repair damaged DNA, but this ability decreases with age. NAD+ is one of the most important components of this process.

The amount of NAD+ in the body also declines over our lifespan.

Increased amounts of the enzyme in mice helped to protect the DNA repair process.

If researchers can find a way to keep NAD+ levels high throughout life, they may be able to slow aging.

NAD+ MIMICS CALORIE RESTRICTION

Fasting and calorie restriction increases the body’s ability to repair and recycled cells through autophagy and reduced inflammation.

Calorie RestrictionNDA+ can mimic the effects of a person who starves their body of calories; leading to increased longevity and decreases in the risk of cancers.

When calories are restricted, the body produces Nicotinamide phosphoribosyltransferase (NAMPT).

NAMPT is an enzyme that is critical to the creation of NAD+; thus, higher levels of NAMPT could be another method of rejuvenation treatment.

Research results show that NAMPT is associated with rejuvenation.

SIRTUINS

While at Harvard in 1999, Sinclair found that the protein Sirtuin 1 (SIRT1) can delay aging in yeast.

SIRT1 rejuvenates yeast by decreasing the number of extrachromosomal rDNA circles.

Study results on the applications of SIRT1 are among the most significant discoveries for anti-aging treatment.

There have been numerous studies that were inspired by Dr. Sinclair’s original research.

The results of these studies show that SIRT1 can rejuvenate yeast and potentially humans.

RESVERATROL

In 2003, Dr. Sinclair joined in on research that was being conducted by scientists at Biomol Research Laboratories.

Resveratrol FormulaThe researchers at Biomol Labs found out that resveratrol could stimulate SIR2.

Dr. Sinclair was determined to work with the laboratory after hearing of this discovery.

Biomol Laboratories’ research with Dr. Sinclair led to the discovery that resveratrol is an anti-aging compound; these findings were published in a 2003 issue of the Journal of Nature and Science.

David Sinclair on Anti-Aging NAD+ Fad & Human Trials of NMN

Professor David Sinclair, Ph.D. has dedicated his research to what he believes may be the best innovation in the field of anti-aging.

Sinclair’s research indicates that by boosting NAD+, he can repair DNA.

Professor David A. SinclairThrough this, he has shown the world a possibility of a real-life “fountain of youth.”

Clinical trials on NDA+ that mimic those done on mice are still needed.

Dr. Sinclair has proposed a human study, and the world waits to see if the results are conclusive.

There have been studies into the two precursors of NDA+;

NMN is one of those NAD precursor molecules.

David believe that talking MNM as an anti-aging supplement may increase health span and life span in people.

Let’s review some of the most prominent NMN supplement research and science.

Is NMN Safe (Side Effects)?

What are the side effects of nicotinamide riboside?

In human studies, consuming 1,000–2,000 mg per day had no adverse effects.

NMN does not currently have any safety indications from the United States FDA. This status is an indication that NMN is safe for use; the FDA.
is known to be a strict regulatory commission with rigorous guidelines.

Published scientific findings state that NR when compared to NMN, is a safer and more effective ingredient for raising NAD+ levels.

That doesn’t mean that NMN isn’t safe, but there may be more efficient rejuvenation treatments.

NR has had more clinical trials and studies than NMN, so more research and further investigation is needed into NMN.

What Does Nicotinamide Mononucleotide Do?

Nicotinamide Mononucleotide (NMN) is a nucleotide, which is composed of NR. The main area of research into NMN has been through animal study.

There is a lack of human clinical studies, despite encouraging evidence of tests performed on animals. These animal studies were looking at the neuroprotective and anti-aging properties of the NMN compound.

(NMN)

There are a large number of dietary supplement companies that are marketing NMN as a proven rejuvenation treatment.

These advertisements shouldn’t be taken seriously because NMN hasn’t undergone any clinical trials on humans.

Again, that doesn’t mean that NMN supplements are not safe; it does mean that consumers should be informed when shopping for these supplements.

How to Take NMN

Dietary supplement companies frequently sell NMN as capsules or dissolvable tablets. However, in clinical studies on mice, NMN is administered through injections.

Currently, the only way for people to add NMN into their diet is by purchasing a supplement.

Further research must be conducted to determine the most efficient method for humans to take NMN.

Safe NMN Dosage for Humans

Because NMN hasn’t undergone human trials, a safe dose for human consumption is not known.

NAD LevelsSafety and efficacy research must be conducted, followed by peer-reviewed, human clinical trials.

Currently, it is recommended that anyone seeking anti-aging treatment should consult their physician before purchasing or taking an NMN.

On the other hand, NMN product labels recommend a daily, two pill or lozenge program taken before each meal.

A review of NMN products reveals that this is the most popular method of NMN consumption.

How Bioavailable is It?

Bioavailability of NMN is highly debatable. The issue is whether a sufficient dose could get through the gut without being changed by stomach acid. With this undesirable possibility in mind, various manufacturers have endeavored to make products that can survive passing through the stomach. Some manufacturers offers extended release versions that designed to prolong  and slow the absorption.

The study found :

absorption from the gut into blood circulation starts within 2–3 min and within 15 min, it is completely absorbed into tissue. Then it is converted and stored immediately as NAD+ in tissues like liver, skeletal muscle, and cortex. This increase in hepatic [liver] NAD+ content persists for about 30 min. After six months of molecule administration, this spiked concentration of NAD+ can be observed in the liver and brown adipose tissue, however, not in skeletal muscle and white adipose tissue

Is NMN the Same as Niacin?

Is Vitamin b3 the same as nicotinamide riboside?

Niacin, more commonly known as Vitamin B3, is the precursor to NMN. Therefore, Niacin is a more basic form of NMN.

Niacin FormulaNiacin has already been proven to have various health benefits, and it is inexpensive.

Human trials have previously been conducted on Niacin, proving that it is safe for consumption.

Furthermore, many experts predict that NMN treatment would be substantially more expensive than Niacin treatment.

However, it is a much more complex compound and may have several more benefits or consequences related to anti-aging.

Human trials for NMN treatment are to be expected to take place in the coming years.

What foods contain Nmn (natural food sources)?

  1. Broccoli
  2. Cucumber
  3. Cabbage
  4. Avocado
  5. Tomato
  6. Edamame

Final Words on NMN Supplements

Alive By Nature and ProHealth NMN are great supplements made by reputable companies.

Tru Niagen n1 AlternativeIf you are interested in taking an NMN supplement, they are our recommendation.

Tru Niagen is certainly a better choice for a more studied and conclusive precursor to NAD+.

Whether you are buying off our list or looking at another supplement, you should always keep in mind the company’s reputation and its business practices.

***These statements have not been evaluated by the Food and Drug Administration. These products are not intended to diagnose, treat, cure, or prevent any disease. Individual results may vary.***

 

MindLab Pro Review

Mind Lab Pro Review (2020 Update): Science Flaw & [Major Red Flags]

Julia Stearns

Nootropics or smart drugs such as the ones from Mind Lab can unlock your true brain potential, make you live longer or they can mess you up.

It all depends on the product, brand, ingredients plus people and research teams behind them.

MindLab LogoI’ve spent lots of money and tried countless products to find that only a selected few products have some scientific backings behind them, and even out of those backed by science, they are not created equal.

Choosing a good nootropic stack can make or break your life, your performance, and your health.

Here is what you need to know…

Many students, creative workers, and business people are taking Modafinil or Adderall (amphetamine) to increase their performance. Those can have major side effect.

Is this really necessary?

About Mind Lab Pro Company

Mind Lab Pro is manufactured by a company called Optinutra. Mind Lab Pro company is based in the UK, but the product is made in the USA.

MindLab Pro CompanyOptinutra says it sells “advanced nutraceuticals.” This combination of “nutrition” and “pharmaceuticals” should imply that their nutritional nootropic
supplements are innovative and medically sound.

Opti nutra targets performance-driven people who aim to improve their health and biological functions.

Optinutra claims it uses high-quality ingredients, made from patented nutrient formulas.

Mind Lab Pro ingredient list is supposed to be purity-tested and fresh.

The company uses innovative technology in its manufacturing process, to render safe and effective products.

Mind Lab Pro Ingredients

Mind Lab Pro offers ingredients that promise increase performance, give you more energy (and brain energy) and improve brain regeneration. The ideal is to supply us with Universal Nootropic formula to target a many brain pathways as possible (6 pathways).

It also promise to deliver nootropics in clinical range dosages and helps with both immediate nootropic-performance and long-term brain health and function.

60 Capsules MindPro Labs

Here’s the list of Mind Lab Pro ingredients:

  • 5 mg (125% DV) Vitamin B6 (as BioGenesis™)
  • 100 mcg Vitamin B9 (25%DV) (as BioGenesis™)
  • 5 mcg (125% DV) Vitamin B12 (as BioGenesis™)
  • 250 mg Citicoline as Cognizin
  • 150 mg Bacopa monnieri extract (24% bacosides with 9 bioactives) (aerial parts)

Bacopa monnieri is one of the best nootropics according to an interview with Dr. Con Stough.

  • 500 mg Lion’s Mane Mushroom (full spectrum) (fruit)
  • 100 mg Phosphatidylserine (as Sharp-PS Green from sunflower lecithin)
  • 175 mg N-Acetyl-L-Tyrosine
  • 100 mg L-Theanine (Suntheanine)
  • 50 mg Rhodiola Rosea (3% rosavins and 1% salidroside) (root)
  • 75 mg Maritime Pine Bark Extract (95% proanthocyanidins)
  • Pullulan (Plantcaps® capsule)

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Now let’s discuss them one by one, so you can understand their benefits:

Cognizin®

Cognizin, the patented form of Citicoline, has an important role in improving electric impulses sent by neurons, which gives more energy to your neurons (brain energy).

CognizinCiticoline is involved in the creation of a brain phospholipid called phosphatidylcholine, which helps repair neurons.

The studies show that your brain energy and focus is increased by 14% and your brain membranes for 26% faster.

Cognizin Citicoline improves the activity of your brain’s neurotransmitters, which act as antioxidants.

This substance improves your mental clarity, mood, memory, and other cognitive processes.

It’s even said to have anti-aging effects on the brain.

Phosphatidylserine

This phospholipid compound has various brain bioactivities and various nootropic benefits.

PS takes up 15% of the brain’s fats, and you can find it in your neurons’ membranes.

Its role is to keep the brain cell membrane fluid, to improve the receptors’ activity and to make essential neurotransmitters like dopamine.

PhosphatidylserinePS increases the consumption of glucose by your brain, which means the brain cell production is accelerated.

This phospholipid seems to have a role throughout your neurons’ lives, from their creation to their repair and maintenance.

PS activates immune cells, which get rid of damaged neurons, so working neurons can thrive.

This leads to a decelerated cognitive decline, sharp memory and decreased risk of depression and reducing anxiety.

Besides, PS is FDA-approved for its ability to improve cognition.

The patented PS used by MindLab Pro is called Sharp-PS® Green.

This substance that’s made from sunflower lecithin features no GMOs and no soy.

Bacopa Monnieri

The active bacosides in Bacopa Monnieri are antioxidants, which protect your brain cells from damage made by radicals.

These bacosides are involved in the creation of various neurotransmitters like acetylcholine, GABA, and serotonin, which improve your memory, mood, and clarity.

Bacopa Monnieri

Bacopa Monnieri is involved in improved learning and retention abilities.

Research shows that it can also make you more relaxed and help you think better even under stress.

Lion’s Mane Mushroom

This mushroom is the only one that makes your brain healthier.

Lion's ManeIts active nootropics increase Nerve Growth Factor (NGF) according to various animal studies.

This NGF improves your brain’s ability to regenerate neurons and therefore supports neuroplasticity.

Neuroplasticity is your brain’s ability to stay flexible so that it can acquire new knowledge and memories.

It has been proven effective in human studies for improved cognitive performance and optimizing your mood, giving you a mental edge.

These performances dropped as soon as the people stopped taking the supplement.

Maritime Pine Bark Extract

It features powerful antioxidants that get through the blood-brain barrier so they can effectively fight free radicals.

Maritime Pine Bark ExtractThese antioxidants signal your brain to produce nitric oxide, which improves your blood flow and circulation because it relaxes the blood vessels.

Improved blood flow & circulation to your rain translates into more mental energy (brain energy), faster brain regeneration, brain optimization, and an increase in cognitive function.

Other benefits include improved attention, focus, learning, and memory, along with better memory recall and brain health for the long-term.

N-Acetyl-L-Tyrosine

This amino acid compound is used for the creation of catecholamine neurotransmitters like dopamine, epinephrine, and norepinephrine.

Their role is to advance your mood and improve studying, learning, attention, and memory.

N-Acetyl-L-TyrosineSome animal studies show that L-Tyrosine fights against brain stress.

Human studies emphasize that L-Tyrosine is related to better working memory when you’re multitasking.

This compound can raise your mental performance even when you’re stressed or sleep-deprived.

N-Acetyl-L-Tyrosine is easier to absorb in your brain, and it’s bioavailable, which makes it more beneficial to your brain than regular Tyrosine.

L-Theanine

L-TheanineThis substance increases your alpha brainwaves, which improve mental clarity, creativity, and calmness.

L-Theanine is involved in the production of relaxation-inducing brain neurotransmitters, such as dopamine, GABA, and serotonin.

It can also protect your brain cells from age-related damage, and sharpen your attention and focus.

Rhodiola Rosea

Rhodiola is thought to enhance the production of neurotransmitters like norepinephrine, dopamine, and serotonin, which improve cognition.

Rhodiola RoseaIt’s also believed that it can help them pass through the blood-brain barrier so that they can fight free radicals.

Apart from antioxidant properties, Rhodiola decreases the formation of stress hormones like cortisol so that you can function better under stress.

Besides, i has a long tradition of being used for improved memory, attention, mood, and learning.

Russian Olympic athletes use Rhodiola as a legal supplement to increase their physical performance.

Vitamins B6, B9, and B12

Vitamins from the B-complex improve brain health. B6, B9, and B12 regulate your homocysteine metabolism, to reduce brain degeneration and cognitive decline.

B6, B9, B12The combination of these three vitamins stabilize your mood and improve your mental clarity.

The patented BioGenesis uses this synergistic trio to fight brain aging and to improve blood circulation to the brain.

This complex is shown as easy to absorb, meaning it can increase your creation of brain chemicals effectively (optimized brain chemistry)

BioGenesis can increase your brain energy metabolism (Busts fatigue, brain fog and support quick thinking and mental agility, and focus) and protect your neurons because it speeds the myelin formation process – the fatty cover that protects your neurons.

Pullulan

This biopolymer is widely used in the food and pharmaceutical industry.

Pullulan

It has low calories and is resistant to digestion, so it acts as a dietary fiber.

Pullulan can be used as a filler, but it also works as a prebiotic, to enhance the production of beneficial gut bacteria.

Is There Robust Clinical Support for Mind Lab Pro’s Ingredients?

Optinutra offers various links to published research in peer-published magazines to prove that Mind Lab Pro works.

IngredientsMost of these studies took place under optimal conditions, such as double-blind, randomized, placebo-controlled clinical trials.

However, I noticed that some of the research provided by Optinutra features few subjects, around 60 to 100.

Studies that involve thousands of subjects and take place throughout a few years would be more insightful.

But until these appear, the current clinical studies that back up Mind Lab Pro’s ingredients have a high degree of credibility because they’re organized under strict quality control.
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Upgraded Formula

This review features the new ingredients in the Mind Lab Pro formula, which has been updated in 2017.

Before this update, Mind Lab Pro used pterostilbene and vinpocetine in its composition.

Pterostilbene is a chemical compound with a similar structure to resveratrol – that miracle ingredient in grapes which is thought to delay the aging process.

Pterostilbene

However, pterostilbene has been shown to increase bad cholesterol levels.

Vinpocetine, extracted from the lesser periwinkle plant, is now prohibited by the FDA for therapeutic use.

Even though it improves blood circulation (blood flow) to the brain, it’s tied to bleeding disorders and a weakened immune system.

As such, it can only be prescribed by your GP and not featured in nutritional dietary supplements.

The new Mind Lab Pro formula has replaced these with Maritime Bark extract, the BioGenesis complex, and contains Bacopa Monnieri.

These are safe, natural ingredients and feature plenty of advantages like the ones I discussed above.

Ho MindLab Supplement Works?

Those mentioned ingredients should have a corresponding impact on each other, holistically promoting mental capabilities more powerful than they would be if taken separately. The PS and Citicoline work to increase the flow of acetylcholine, increasing cognitive function and memory, while concurrently giving basic compounds to build cells. The L-theanine, Rhodiola Rosea, and Bacopa Monnieri can reduce tension and help to improve your mood. NALT stops your brain from dopamine depletion.

The maritime pine bark extract acts as a potent antioxidant that clear dead cells while encouraging livelier focus, while the Lion’s Mane promotes new, robust connections. The formula appears to present overlying effects that affect all of the primary brain function in a harmonious and balanced manner. It is also important, unlike another nootropic, MindLabPro does NOT add any stimulants (besides the mild effect of Rhodiola) or artificial mixtures.

Many stacks venture to trick their consumers by filling up their pills with low-quality caffeine or some other trick to make a moderate improvement, leading them to believe it’s “working.” In reality, some of those stacks are not providing you with anything to boost cognition. Mind Lab Pro takes a more complex path, which is more efficient.

Mind Lab Pro Benefits

I already told you guys some of the benefits of Mind Lab Pro when I told you about what each ingredient can do.

But the sexy combination of these science-backed natural nootropics can improve your attention, communication skills, creativity, focus, memory, cognitive processing speed, problem-solving abilities, and relaxation.

Can Improve Your AttentionMind Lab Pro is excellent for people who have to multi-task, work under stress, and who want to improve their performance.

I love Mind Lab Pro’s flexible formula because all its ingredients are pretty much the best nootropic stacks, so they improve your mental performance and offer important nutrients for your healthy brain.

These nootropics increase your brain’s energy, alpha waves, and oxygenation.

They’re involved in either the creation, maintenance, or repair of your brain cells, so Mind Lab Pro is a versatile, flexible, and comprehensive nutritional supplement.

How Long Does it Take for It to Work?

Each person is different, but most online reviewers say they see results in a few days to two weeks after they started taking Mind Lab Pro.

Physical PerformanceThe thing is that Mind Lab Pro doesn’t use clinical range doses on all its ingredients, even if it says it does.

Some are well below the line, which means Mind Lab Pro meets this clinical range only if you take a double dosage every day.

This can get a bit expensive, and it’s also misleading advertising.

But what that means is you can take a double dose to increase your short-term physical performance.

Mind Lab Pro won’t work as a true preworkout supplement, as it won’t give you a massive energy boost, but it will improve your mood and confidence.

Mind Lab Pro Side Effects

There are no known side effects of Mind Lab Pro.

The pills are well-tolerated because this product features natural, vegan, quality ingredients, with no artificial fillers, except Pullulan.

This thickening agent has not experienced any side effects or adverse reactions.

Mind Lab Pro Review Summary

So, what have I learned after taking and researching Mind Lab Pro?

There are various pros to take it every day. The product and company have a strong reputation and plenty of positive Mind Lab Pro reviews.

The ingredients are backed by science, and you can read all about the doses and other excellent research on the official Mind Lab Pro website.

The clean label convinced me, as well as the fact that the ingredients are smart nootropics, combined effectively.

Optinutra Brand

This supplement boosts your brainpower and has a smart formula; it’s strong, effective, and fairly affordable.

There are no cons I can think of, except that Optinutra is the only brand that manufactures Mind Lab Pro, which means you can only buy this from them.

Mind Lab Pro vs. Alpha Brain

The Mind Lab Pro and Onnit Alpha Brain formulas are quite similar, and they both feature no caffeine.

Alpha Brain focuses on increasing your brain’s alpha waves (brain waves), which enhance mental clarity and performance, and relaxation.

There are three proprietary blends that Alpha Brain uses for this purpose:

Onnit Flow, a mix of L-Tyrosine, L-Theanine, Oat (straw) extract, and Phosphatidylserine, should increase your mental flow and creative thinking.

Onnit Focus, a mix of Alpha-GPC, Bacopa, and Hup-A, help you focus and boost your memory.

Vs Alpha Brain

Onnit Fuel, which combines L-Leucine, Vinpocetine, and Pterostilbene, should support and improve blood flow to your brain and help make more antioxidants that protect your brain.

However, as I pointed out before, Vinpocetine can cause bleeding disorders, and Pterostilbene increases your bad cholesterol levels, which is why Mind Lab Pro removed them from its formula.

Besides, Onnit Alpha Brain uses an AC-11 Cat’s Claw extract, which is unjustly deemed as a nootropic.

However, it can act as an anti-inflammatory and antioxidant.

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That said, Alpha Brain has fewer quality ingredients and a less clean formula because it doesn’t feature just nootropics.

Plus, Alpha Brain targets other people, healthy adults who want to lift their moods and to reduce stress levels.

Mind Lab Pro vs. Qualia Mind

Both Mind Lab Pro and Qualia Mind work. However, Qualia has a less clean formula, with 42 ingredients.

Its nootropic compounds are synthetic, instead of bio-active like those featured by Mind Lab Pro.

There are some extra vitamins featured here, like vitamin C and D, plus a range of antioxidants, anti-inflammatories, minerals, and amino acids.

Versus Qualia

Qualia also features caffeine and Pterostilbene – we talked about it.

I have some reservations about how these work separately and together.

For instance, Noopept has some tolerance risks, Pterostilbene increases bad cholesterol, and DHEA has a banned pheromone status.

Combining 42 different compounds might lead to weird chemical reactions and thought-of side effect.

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On the other hand, Qualia features more nootropics in its composition and is more affordable.

Mind Lab Pro vs. Lumonol

Lumonol has a brave formula, which revolves around Noopept.

This is a controversial nootropic supplement, with a similar structure to racetam. It’s supposed to improve your memory, mental acuity and it’s slightly psychostimulating.

However, Noopept can make you dizzy, irritable, and give you headaches.

While the ingredient list seems pretty clean, their quality doesn’t stack up to that of Mind Lab Pro’s ingredients.

MindLab Vs Lumonol

For instance, Mind Lab Pro uses Citicoline which is better than the AlphaGPC found in Lumonol.

Lumonol also uses Ginseng, Ginkgo, and L-Tyrosine, but these nootropics appear in a cheap-O form.

Hordenine, another ingredient in the Lumonol formula, isn’t even backed by science.

Besides, Lumonol doesn’t show its dosages on the ingredient list. Mind Lab Pro shows all of its dosages.

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I would recommend Mind Lab Pro to anyone and in my opinion, that makes nootropic Mind Lab Pro better and more effective than Lumonol, especially in the long-term.

Final Words on Nootropic Dietary Supplement

Mind Lab Pro seems to be an effective supplement.

I tried it for 30 days, and I could see good improvements in my memory and cognitive ability. I feel if I was able to process information faster and better.

Mind Lab Pro is much better (probably the best) than other products I tried, and you can see for yourself how it compares to Qualia, Lumonol, and Alpha Brain.

The best place to buy Mind Lab Pro is the Optinutra official website, where you can also read the research behind it. If you live outside of North America, they provide worldwide shipping options!

Amazon version might also be available, with good shipping and return policies.

However, Optinutra offers significant discounts for bulk buys.

The statements on this page have not been evaluated by the Food and Drug Administration. These products are not intended to diagnose, treat, cure, or prevent disease.
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7 Best Anti Aging Supplements

7 Best Anti-Aging Supplements (2020) | #1 Longevity & Younger Look!

There are a lot of products out there claiming to help fight the signs of aging. Wherever you look, there are claims of everlasting youth and longevity being shouted at you. It’s hard to know what’s real and what’s a lie.

There have been some promising studies in the field of anti-aging supplements that have shown some promising results.

Some supplements have shown remarkable effects on skin elasticity and other topical signs of aging. Anti-Aging SupplementsMany have shown not just to help the look of aging but also to slow down or reverse the aging process inside as well.

Now:

There is no all in one anti-aging supplement!

Some can reduce muscle loss, joint pain, improve heart health, help with weight loss, and strengthen your bones. Others can help enhance vision, strengthen a weakening immune system, and enhance overall performance.

It’s important to understand a few reasons why these supplements work and the science behind them. When you have a basic understanding of how they work, it’s harder to have the wool pulled over your eyes.

We looked into seven of the most well-researched supplements to help with longevity and what makes them so effective. We take an in-depth look at the mechanisms and the results of many studies below.

Best Anti-Aging Supplements to Slow Sign of Aging That May Actually Work (2020)

1. NAD SUPPLEMENTS – #1 Anti-Aging Supplement & Cell Rejuvenation

As we age, the NAD+ produced in our bodies is dramatically reduced. It is thought that NAD+ reduction may be one of the biggest culprits of why people age at all.

In a Harvard Medical School study, scientists found that by increasing NAD+ in mice they could dramatically reverse the aging process. The oral administered high levels of NAD+ daily.

Lose NAD+The result was that two-year-old mice looked and were genetically similar to mice only a few months old.

This same study on humans hasn’t yet been completed, but after the discovery of what NAD+ could be capable of, there have been numerous human clinical trials on NAD+.

These trials have shown some promising results for humans.

One of the ways NAD been shown to increase NAD+ production in aging bodies is through its precursor NR.

Tru Niagen Advanced

When we take a nicotinamide riboside, it will naturally produce NAD+ and may aid in repairing our cells and keep our bodies younger longer (Read more here)

In a study, scientists discovered that by giving nicotinamide riboside to elderly mice, it restored their organs’ ability to regenerate.

NR compounds are now available for sale as a supplement.

The leading brand is Tru Niagen who sells potent, powerful NR supplements.

Their patented product is used in other supplements, and they lead the way in NR and NAD+ research today.

If you are looking for a trusted NR supplement, Tru Niagen may be the best option and currently #1 anti-aging supplement on a market.

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2. COLLAGEN PEPTIDES – Best for Younger Looking Skin?

What supplements to take to look younger?

It would be Collagen.

Collagen is a protein abundant in bones, muscles, tendons, and skin. Collagen works in your body as a buffer between bones. It helps with the elasticity of skin and muscles.

It is also essential for repairing and preserving connective tissues like ligaments and tendons.

As we age collagen production slows down in our body’s and as a result, we get degradation of our overall elasticity.

Collagen is one of the top overall anti-aging supplements when it comes to skin and bone health.

There have now been numerous studies that show that taking an oral supplement of collagen you can increase skin elasticity, get to hold moisture and relieve joint pain.

It’s also used to help treat osteoarthritis. It is not a cream but a great skincare product nevertheless.

By taking collagen before and after aging begins it can help treat internal and external problems related to aging.

There are very few known risks of taking collagen.

This one of the best anti-aging skin supplements and it is widely prescribed by doctors and dermatologists worldwide.

The best brand we have found for a good, clean, and naturally sourced collagen is Perfect Keto Collagen.

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3. Resveratrol to Fight Aging

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Resveratrol is the reason red wine was talked about so much in the news. It was recommended to keep your heart healthy you should have a glass of red wine a night.

Out of all the compounds found in red wine few are as well researched and have shown as many promising results as resveratrol. Throne RESVERATROLResveratrol works by activating and increasing sirtuin activity.

It has been shown to slow down and reverse the aging process. It can mimic the effect of a calorie restriction by decreasing insulin sensitivity, restore cardiovascular health, and promote autophagy. There have been numerous studies shows that resveratrol can help with heart health.

It has been shown to have anti-aging capabilities including slowing down cognitive deterioration. Resveratrol has also been shown to help to reduce and minimize wrinkles.

A cup of wine only gives you a tiny dose of resveratrol. In fact, in the whole bottle of red wine, there is only 0.2 to 5.8 mg.

Throne Research CapsuleTo get 500 mg of resveratrol, you would need to drink 40 bottles of wine. Some supplements offer a hefty dose of resveratrol without the overconsumption of wine. Thorne Research offers a good Resveratrol supplement called ResveraCel.

It includes a good dose of naturally sourced resveratrol as well as other healthy sirtuin-activating compounds found in red wine.

This pill also includes Tru Niagens NR compound as well. It’s an excellent buy for an all-around longevity supplement.

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4. RAPAMYCIN

Rapamycin is a prescription drug used to treat people who receive a transplant or have stents put in their heart.

Recently Rapamycin has been being looked at because of its ability to act as an inhibitor of mTOR.

Rapamycin is not a supplement but rather a yeast-derived antibiotic.

RapamycinIt has been shown to extend the lifespan of yeast, worms, flies, and middle-aged mice.

Rapamycin mimics the effects of calorie restriction, promoting autophagy, lowering insulin resistance, and reducing mTOR levels.

It has been shown to have a reversing or slowing down effect on many age-related diseases like heart disease, cancer, Alzheimer’s disease, and loss of eyesight.

This drug, while used on humans for other purposes, has not been tested for long term use in helping with longevity. It is not known how dangerous it can be when taken for long periods.

Moreover, because this drug affects your blood glucose levels, it can cause a rapid decrease in blood sugar.

When blood glucose levels drop rapidly, it can cause severe side effects like fatigue, loss of consciousness, and even death.

Do not take this medication unless prescribed by a doctor.

It is recommended that you test your blood sugar levels consistently while taking it.

5. METFORMIN

Metformin is another prescription medication that works on the AMPK pathway and may reduce mTOR levels. It is most commonly used to treat diabetes.

By lowering blood sugar levels, it can mimic the effects of long term fasting and help to reverse the symptoms of ingesting too many carbohydrates.

There has been some promising research (animal studies) into metformin in terms of anti-aging and longevity, but research into human trials is still needed.

Metformin

This is another drug that needs to be closely supervised by a doctor as it can cause rapid decreases in blood sugar.

But there is a supplement that may mimic the effects of these two prescription drugs. For a natural alternative, there’s Berberine.

It’s a quaternary ammonium salt that is produced from plants. It is thought to work similarly to metformin and can help safely regulate blood sugar.

It can decrease inflammation caused by excessive sugar consumption. It has been shown to work on the AMPK pathway to promote autophagy.

This supplement doesn’t have many adverse reactions but shouldn’t be taken if someone is already taking blood sugar medication.

6. COENZYME Q10 Supplement

Coenzyme CoQ10 is a well known antioxidant compound; your body naturally produces it to help convert food into usable energy.

Q10There has been some research that points to CoQ10 improving the elasticity of the skin, reducing wrinkles, and improving overall texture.

It may also help alleviate age-related issues such as oxidative stress brought on by a CoQ10 deficiency.

As we age, our bodies slow down their production of CoQ10.

By supplementing this coenzyme, it may be able to restore its ability to act as an antioxidant, reduce oxidative stress, and help with longevity.

7. CURCUMIN / TURMERIC

Turmeric is known around the world as a culinary spice.

In some languages, it is called curcumin.

Confusingly the anti-inflammatory substance inside turmeric has also been named curcumin.

Meriva SFCurcumin, the active substance in turmeric, has been shown to help prevent cancer and most importantly decrease inflammation.

Many issues with the body come back to inflammation.

Heart disease caused by plaque is caused when inflammation swells the arteries, and the body produces cholesterol to heal the rips and tears.

Joint pain, chronic fatigue, and muscle pain have all been linked to inflammation.

By taking turmeric or refined curcumin, research has found that it can help keep down inflammatory responses in the body.

The best curcumin supplement choice is Thorne Researches Meriva SF this curcumin offers a 29 times absorption rate than other pills.

That is because the company has made this curcumin more bioavailable.

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8. FISH OIL / KRILL OIL

Omega-3 fatty acids are essential for healthy aging,  healthy living, and staying generally healthy. Whether the source is from fish oil or krill oil, omega Omega-3 fatty acids can provide many beneficial effects.

They have been shown to ensure heart health, lower risk of muscle deterioration, and prevent loss of vision.

Because of the way our body utilizes omega fatty acids they are crucial to cognitive health.

Fish Oil Omega 3Your body needs fatty acids to function. Ingesting enough omega 3 fatty acids has been shown to reduce the risk of cognitive decline and dementia. Many people have been found to lack this crucial fatty acid in their diet.

Taking a supplement can ensure a healthy brain function as well as joints, muscles, and bones as we age.

Nordic Naturals Omega-3 Phospholipids is our recommendation for a good supplement.

Phospholipids are designed to be more bioavailable, especially for people with the APOE4 gene.

Apolipoprotein E or the APOE gene is a gene involved with processing fat in the bloodstream.

If you have this gene, it is a risk factor for late-onset Alzheimer’s.

By taking a bioavailable omega 3 supplements, you may be able to delay or negate the risk of cognitive failure & cognitive decline.

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9. VITAMIN C

What vitamin is best for anti-aging?

It is Vitamin C. We all know that vitamin C can ward off cold or other viruses. It is one of the most potent antioxidants that has also been shown to improve skin texture and appearance.

Viva Naturals Vitamin CVitamin C, also known as ascorbic acid, is a natural way to stimulate collagen production.

Vitamin C is an essential, water-soluble vitamin and antioxidant that is found to reverse and repair sun-damaged skin or aging skin (protects the skin from sun damage or even skin cancer).  It can also help reduce fine lines and wrinkles (anti-wrinkle effect).

Some beauty products are now packed full of vitamin C because of these amazing results, but it is most effective when ingested.

An excellent choice for a naturally sourced and non-GMO supplement would be Viva Naturals Premium Vitamin C with Bioflavonoids.

Bioflavonoids are other plant-derived compounds that have been shown to help metabolize and utilize vitamin C.’

Vitamin C can be considered as one of the best anti-aging vitamins.

Some other products/vitamins that some people believe also having effects are: green tea or green tea extract (antioxidant properties), vitamin E (protects cell membranes), amino acids such as creatine and arginine or L-arginine, stem cell supplements (no proof of working), telomere products to increase telomere length (no proof of working), Off-label use of hormones (estrogen and progesterone)

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10. Crocin

Crocin from Kashmiri saffron (Crocus sativus) flowers are reported to have antipyretic, antitussive, and expectorant properties against cough.

Anti-inflammatory and antiseptic properties have also been reported for this compound. Antioxidant properties were reported. Saffron is the predominant feature of the Indian platelet mix. It is also prominent in the vegetarian version of the mixed rice mix.

The nutritional value of saffron is 20 times that of the gram for gram. Saffron is an excellent source of flavonoids and phenolic compounds. Saffron contains potent anti-malarial, anti-ulcer, and anti-inflammatory properties.

The extract of crocus or crocus mandshurites is used to treat malaria in India and the Middle East. Saffron seed is used in the laboratory to remove nitrogen from the air. Saffron may help in the treatment of diabetes mellitus and high blood pressure.

It is an excellent source of beta-carotene, the precursor to vitamin A. Saffron consumption can also reduce the risk of some cancers. It contains a chemical compound crocetin, a natural flavonoid that has been shown to have anti-tumor and anti-inflammatory properties.

11. Rhodiola For Health and Longevity

One of the easiest ways to get all the benefits of a healthy lifestyle is to get a healthy body. Whether you want to look and feel your best now, or you plan to age with a positive mind, the right supplement can help. Now, let’s get into the details and explore the benefits of Rhodiola Rosea, a supplement that may be effective in improving lifespan, longevity, and both energy and body chemistry. In fact, it has been reported to help regulate blood glucose levels, improve nerve and muscle function, improve metabolism, increase bone density, and cognitive function.

Although it’s a relatively new supplement, with only a couple decades of research behind it, it has earned quite a bit of notoriety. So much so that it’s now available in a nearly endless variety of concentrated forms and at a variety of prices.

So, what exactly is Rhodiola?

Well, it’s a natural plant product that comes from a relatively unknown area in Siberia. In fact, the area of origin is the Rhodope Mountains in Bulgaria. Interestingly enough, it is also one of the oldest recorded sources for medicinal plants on Earth.

Over the years, Rhodiola has been used as a treatment for more than 25 medical ailments, with varying degrees of success. Some of these medical uses are chronic pain, respiratory disorders, gastrointestinal disorders, circulation issues, urinary tract infections, and depression. Interestingly, some of these diseases and ailments are comparable to those which are often found in the elderly, including osteoporosis, cardiovascular disease, memory loss, depression, and cognitive issues.

The Sirtuins: Longevity Gene Activation

Sirtuins are part of a family of proteins that has a role in regulating cell health. There are seven sirtuins in the human body. They play a crucial role in the aging process.

As we get older nicotinamide adenine dinucleotide or NAD decreases in our body.

NAD+ is a coenzyme that is found in all living cells. Sirtuins function through the usage of NAD+.

As this coenzyme diminishes so too does our body’s ability to heal itself.

The Sirtuins Longevity Gene ActivationThe cellular the health of your body depends on the function of your sirtuins.

Your sirtuins need NAD+ to be active. The less nicotinamide adenine dinucleotide you have, the less your cells can heal themselves.

The primary role of sirtuins is to remove acetyl groups from proteins.

This helps the DNA sequence properly. When it isn’t active, that’s when our bodies begin to break down.

Since their discovery 20 years ago scientists have been studying sirtuins nonstop.

They have dubbed them “the longevity genes” because of their function in healing DNA.

By increasing the NAD+ in your body and the sirtuins, you can add longevity to your cells.

NAD+ BenefitsThe research into these two pathways has to lead to some surprising and promising results.

The combination of active Sirtuins and high levels of NAD+ has been shown to have all the same positive effects of calorie restriction and fasting.

Including regulating blood sugar, lowering your insulin sensitivity, and helping to eliminate cancer cells.

They are also shown to slow down or even reverse the aging process.

By taking the precursor to NAD+ called NR, you can increase your NAD+ even as you age.

Supplements can also help increase sirtuins in your body and through the combination of the two they can work to help us stay young naturally.

Anti-Aging Pathways Explained

In the last few decades, scientists have figured out precisely what regulates our cell health.

Through a series of pathways, our cells maintain their function and stay robust and fully functioning.

When these pathways are turned off, bodies start to break down by taking a supplement that can activate these pathways and slow down or reverse the aging process.

We have covered Sirtuins and NAD+ above, but there are other players in this game.

mTOR is another protein that plays a key role in the longevity of cells and ultimately life.

mTorc

mTOR links with other proteins and becomes two different complexes; mTOR complex 1 and mTOR complex 2.

These two complexes regulate different cellular processes.

mTOR is sugar-fed and is currently under scrutiny for having a direct link to sugar diseases like insulin sensitivity, diabetes, and Alzheimer’s.

What has been found is that too much mTOR is a bad thing but too little is also bad. When there is too much mTOR, it can turn off autophagy.

What is AutophagyAutophagy is your body’s way of recycling bad cells and cleaning up the body. Too little mTOR means your body can’t grow new cells properly. The key to harmony is finding the proper amount of mTOR for optimal cell function.

AMPK or 5′ AMP-activated protein kinase is also involved in processing carbohydrates.

A healthy level of AMPK in the right issues can help decrease insulin, improve insulin sensitivity, and promote autophagy.

AMPK is involved in many of the anti-aging pathways including regulating mTOR and aiding sirtuins and NAD+.

AMPK is found in all living cells and is essential to energy balance & energy production. It detects the level of energy and signals the body when it is too high or low.

AMPK Activation TableSo we need to increase Sirtuin activity through NAD+, regulate levels of mTOR, and promote AMPK activity. How is this all done?

Well, one promising way is through calorie restriction and fasting.

If we restrict sugar intake for a while, our body can reset its pathways and fix the levels of these complexes.

Another way is through natural supplements that encourage the correct levels of each of these complexes.

Potential Benefits of Anti-Aging Supplements

Some supplementation promotes AMPK, NAD+, and Sirtuins as well as regulate mTOR in our bodies.

There are choices that can control blood sugar levels and help support natural cell recycling and autophagy.

Decrease Inflammation There are also anti-aging herbal supplements that have been shown to decrease inflammation and degeneration of joints, skin, muscles, and cardiovascular function.

By taking supplements that have been shown to encourage the correct amount of cell regulation.

Then we can encourage anti-aging and restore cell health.

Many of the most promising supplements help inhibit the dangerous effects of too much sugar in our body. Some help attack and safely eliminate free radicals in our bodies.

Through supplements, you can gain some antiaging benefits, restore healthy cell activity, and decrease your risk of heart disease, cancer, free radicals elimination, cognitive disorders, and other deteriorating diseases.

Final Thoughts on Anti Aging Supplements

There are a lot of pills on the market that claims to be the #1 anti-aging supplement.

It can be hard to navigate the barrage of information and advertisements out there.

There are however some actual potentially effective supplements to take. We hope this article helped to shed some light on this subject.

If you want to start taking anti-aging supplements, we recommend CoQ10, collagen, and Tru Niagen or ResveraCel made by Thorne Research.

Together they will provide you with the ability to stay young naturally and aid in cellular rejuvenation. Also, make sure to get enough sleep (7-9 hours is recommended)

**These statements have not been evaluated by the Food and Drug Administration (FDA). This product is not intended to diagnose, treat, cure, or prevent any disease.

Tru Niagen Review (2020 Update) | Anti-Aging Breakthrough or NOT?

The scientific world has been abuzz recently due to the potential world-changing research on NAD+.

In a now-famous study a few years ago, scientists found that they could reverse aging in mice using NAD+.

This study shows two-year-old mice (which is old for mice), become indistinguishable from a few months old mice.

They achieved this by increasing a crucial cellular compound called Nicotinamide Adenine Dinucleotide (NAD+).

REVIEW SUMMARY
There are only a Few Leaders in this Niche Market Segment ( . & .). . is the ONLY Legal Distributor. Product is Tested for Safety & Efficiency.

Countless Anecdotal Evidence Showed that Product Provides Energy and Vigor Throughout The Day & Scientifically Shown to Raise NAD Levels. Now. (.).

  • 100+ Preclinical Studies
  • NIAGEN was successfully reviewed under the FDA’s new dietary ingredient notification program (NDI)
  • 20+ Owned and Licensed Patents

Tru Niagen SupplementAs a result of these groundbreaking studies on increasing Nicotinamide Adenine Dinucleotide, several new products come spring into the market containing the NAD+ precursor nicotinamide riboside (NR).

Aside from its anti-aging effects, these supplements have shown other potential benefits.

Several studies, as well as many customers, have reported a wide range of benefits: a reported boost in energy levels, improved cognition, enhanced sleep activity, as well as many other benefits.

We wanted to know if this was all hype or a truly groundbreaking vitamin supplement. So we decided to look into it.

If you, like many others, have been looking into NAD+ then you may have heard of Tru Niagen.

They have a good reputation and are pioneers in the field.

Their patented nicotinamide riboside compound has undergone rigorous clinical trials and testing, and the claims on the benefits sound almost too good to be true.

TRU Niagen Nicotinamide Riboside (NR) Advanced NAD Supplement Review

We took a deeper look into Niagen and give an updated review for 2019 to see whether or not this NAD Supplement product truly is the best longevity supplement and an anti-aging breakthrough product.

Niagen Research

In the year 2004, Dr. Charles Brenner discovered nicotinamide riboside (NR) could potentially increase vital cellular resource levels. He is Chief Scientific Advisor for the Truniagen brand!

The Harvard Medical School study found that older mice had fewer NAD+ than younger mice.

They dramatically increased the mice’s NAD+ levels through oral administration.

After the study concluded, it was found that the older mice looked and were genetically identical to much younger mice.

TruNiagen SupplementThe lead scientist on the scientific study, David Sinclair says: “We can’t tell the difference between the tissues from an old mouse that is two years old versus a young mouse that is three to four months old.”

Although the same study hasn’t yet been performed on humans, there have been several human clinical trials on NAD+ that have reported a variety of health benefits.

In fact, more than 150 scientific articles have been published about NAD+ and NR compounds since 2004.

Each one is revealing more potential benefits of taking a product such as Tru Niagen.

Some of the benefits mentioned in these clinical studies are, of course, anti-aging. It may also improve mental clarity and prevent cognitive deterioration diseases like Alzheimer’s.

In another study on mice, it was found that by giving nicotinamide riboside to elderly mice, it restored their organs’ ability to regenerate.

This study concluded that Tru Niagen nicotinamide riboside has the potential to prolong life.

But further reviews and research into human trials are needed. It would seem that the research is pointing to NAD+ having a remarkable ability to keep cells young and extend their life.

NR and NAD+ may be the future of research into curing and reversing degenerative diseases.

What Are The Tru Niagen Ingredients

Tru Niagen contains a form of B3 that has been proven to raise NAD+ levels safely in humans.

Their compound is made in facilities in the United States and undergoes rigorous testing.

FactsThe key ingredient is nicotinamide riboside chloride which is the precursor to NAD+ in our bodies.

The NR compound in Tru Niagen is a patented modified version of vitamin B3 that facilitates the natural production of NAD+.

Nicotinamide riboside is found in trace amounts in milk, avocados, and other vegetables.

But these trace amounts are not enough to encourage NAD+ production. Each of Niagen capsules contains 150 mg of NR.

There are a few other ingredients in the capsules, but they are there to keep the NR working and fresh.

Tru Niagen capsules are guaranteed to be vegetarian, contain no animal by-products, and no artificial flavors or colors. The capsules are the nut, gluten and caffeine-free.

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How to Take Tru Niagen

What is the best time to take Niagen?

The company recommends taking 300mg (two capsules) of Tru Niagen at the same time every day.

You can take with or without food in the morning or at night.

The company recommends taking two of their 150mg capsules a day.

Once in the morning and once in the evening, both times with food. Based on one study this may be too little.

CapsuleMore research is needed into the best dosage to take for optimal results in humans.

Your dosage may also depend on how you react to Niagen.

There have been a few mild reported side effects, most of the mitigated when ingested with food.

Because as we age our NAD+ levels decrease it is possible that it would be more beneficial to take more if you are later in life.

Talk to your doctor if you want to try taking more than the recommended dose.

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How Does It Work?

NAD levels in humans decline as we age and metabolic stress contributes to changes in our overall health & wellbeing. Tru Niagen is a safe and effective way to encourage your body to make its own NAD naturally and increase nad. Nicotinamide riboside or NR is the main ingredient in Niagen.

How does it workWhen our bodies receive NR, they will be able to produce the NAD+. Your body needs NAD+ in its natural form to allow your cells’ mitochondria to make energy. As our bodies age, they make fewer NAD+ by taking a dose of NR twice a day (not a particulary high dose), we can stop the plummeting levels of NAD+ in our bodies.

Nicotinamide riboside is a direct path to the production of NAD+. This allows your body to save time and energy in the production of NAD+. The more NR in the human body, the more it can produce and use NAD+. This is why NR is considered by most researchers to be the most efficient booster of NAD+ around. Taking 300mg per day of Tru Niagen for eight weeks shown to raise NAD blood levels by 40 to50 percent.

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What does NR Do and It’s Purpose?

NR, a protein-derived natural molecule, was used as a dietary supplement, but only with limited success. Nicotinamide riboside acts on the mitochondrial level. Mitochondria is responsible for the oxidation of fats.  NR is a protein-derived antioxidant.

It has been studied and found to:

  • reduce lipid oxidation
  • support mitochondrial function
  • reduce the accumulation of oxidized lipids in tissues

The United States Food and Drug Administration (FDA) states that this NR has beneficial effects on inflammatory conditions such as muscle cramps, joint pain, and appetite stimulation. However, this compound’s active ingredients are unknown, so the FDA has not approved it for human use.

NR is a close relative of capsaicinoid compounds. Studies show that NR may be beneficial for disorders, including diabetes, pain, and autoimmune conditions. In addition to its antimicrobial properties, NR may have anti-aging benefits.

What does it do?

Natural NR was first isolated from plants in Japan in 1938 and has been studied ever since. NR is a substance that is found in plants, animals, and water. Science shows that it belongs to a class of compounds called flavonoids. The majority of NR is found in plant or animal tissue, and blood levels are very low. NR also exists in urine and stool.

In vitro and in vivo animal studies have found that NR prevents aging and injury by restoring mitochondrial activity and reducing free radicals. A study in 2004 determined that NR, or other flavonoids, improves the regeneration of muscle tissue and promotes fat oxidation in rats’ muscle cells. The researchers concluded that flavonoids could have both anti-aging and anti-inflammatory effects in animal models.

Is Tru Niagen FDA approved?

Tru Niagen is FDA registered and licensed to be sold for dietary supplementation only. Tru Niagen supplementation contains no preservatives. The active ingredient in Tru Niagen is D-Niacinamide (vitamin B3). The FDA does not approve D-Niacinamide for any medical use. It is also called nicotinamide.

Dietary supplements (FDA) are defined as food additives or food substances intended for use in food for people who cannot absorb or use other foods. Individuals with gastrointestinal disorders such as Crohn’s disease, celiac disease, irritable bowel syndrome (IBS), or inflammatory bowel disease (IBD) are sensitive to niacinamide and may not be able to tolerate it in any form.

Tru Niagen vs. Elysium Basis

The biggest competition for Tru Niagen is Elysium Basis. They use the same ingredient, which is a patented NR compound.

The two companies are currently in a law-suite with each other over the NR compound. The parent company of Tru Niagen, ChromaDex, is the owner of the patent.

Vs BasisFor a few years, ChromaDex licensed the NR compound to Basis. In 2016 parent company  Chromadex revoked the license.

TruNiagen is now the only legal seller of the NR compound. But Basis hasn’t stopped using the patented compound.

This is why Tru Niagen is suing Basis for its illegal use of its patent-protected product.

Another concerning matter is what Chromadex claims they found when testing bottles of Basis for their NR compound. Allegedly they found significant amounts of toluene.

Toluene is used in adhesives, nail polish, and other paints. If these claims are correct, they are worrying.

Tru Niagen Benefits for Weight loss & Energy

One reported a benefit of taking Nicotinamide riboside is that it may help you lose weight.

In a study done on mice, it was reported to have helped speed up their metabolisms.

Lose NAD+

It’s still not clear whether or not this is true for humans as well; further studies are needed.

Many people who have been taking Niagen have reported that it has helped in weight loss.

Another remarkable potential benefit of taking Niagen’s NR compound is that it can increase energy levels.

When NR inside the cell gets to work, it can help form NAD and communicate with sirtuins, the cellular repair promoting proteins. These sirtuins then work to help cells stay young and strong as we age and provide cellular repair.

In multiple user reviews reported significant energy level increase from taking it.

There have also been a few studies on potential energy increases.

One study found that boosting NAD levels can help treat jet lag by helping your internal clock reset faster. NAD is a fundamental resource for cellular energy production.

Another study found that because it may help and support healthy muscle aging, it could help you feel more energetic and younger longer.

Are There Any Side Effects?

Niagen’s nicotinamide riboside compound has few reported side effects in even fewer people who take it.

Benefits for Weight Loss & EnergyIn human trials, people taking 1,000 mg to 2,000 mg per day reportedly had no harmful effects.

There were a few people who complained about some mild side effects.

Some complained of nausea, indigestion, stomach discomfort, diarrhea as well as mild fatigue, and headaches.

People who take the recommended dose of 300 mg a day have said that they experience even fewer side effects

Are There Possible Benefits for Skin & Hair

A new study looking into NAD+ has shown it has some remarkable links to helping support and reverse aging of hair and skin.

In the study on mice, it showed some real promise on reversing wrinkles, encouraging hair health and growth.

However, it is important to remember that because most of these studies have been done on mice, further research into human effectiveness is required.

Is NR The Same as Niacin?

Many people believe that Niagen is just niacin. While it true that a nicotinamide riboside is a form of vitamin B3, it is not actually niacin. NR is a modified version of vitamin B3.

NR The Same as Niacin

This compound is unlike niacin because it doesn’t cause any flush or itchiness in the skin.

The avoidance of the “niacin flush” is one of the benefits of taking this patented version of B3.

Niacin also does not have the same health benefits as NR in clinical studies and clinical trials.

By modifying the structure of the vitamin B3, it aids in the production of NAD+ (To advocate Cellular Energy Production).

Although niacin has some amazing potentials on its own, by taking NR, you can get all those benefits and the healing potential of NAD+ production.

Prices & Where To Buy It

If you want to buy Tru Niagen supplement, we recommend buying directly from their official site. No coupons or discount codes are available, but they have the best price compared to a few of its competitors.

This will ensure you are getting the true NR compound at a reasonable price.

There are some people online who are selling knock offs or heavily marked-up products.

Tru Niagen is also available on Amazon, but we found that it can have a slightly higher price tag.

Final Words

Although it seems more clinical studies and human trials are needed, NAD+ is showing some remarkable potential and evidence into anti-aging and longevity.

Tru Niagen Best ChoiceThe NR compound that Niagen offers has been clinically proven to increase levels of NAD+ in the body.

With its low tendency to cause side effects and testimonies praising its benefits raining in it’s hard not to think taking this vitamin supplement is a bad thing.

It’s hard to believe that a little vitamin supplement can help heal the mitochondria of our cells so well, but that seems to be what scientists are starting to think.

It is now commonly understood the NAD+ is the key to curing and treating many degenerative diseases and helping improve longevity in humans.

One of the safest and most natural ways of increasing NAD+ is to use the precursor to it, NR.

The most trusted producer of nicotinamide riboside is Niagen. They hold the patent for the well tested and safe compound.

NIAGEN has twice been reviewed successfully  nder FDA’s new dietary ingredient (“NDI”) program, and has also been successfully notified to the FDA as recognized generally as safe (“GRAS”).

It would seem that there is very little to lose from taking this vitamin supplement.

The potential benefits of muscle regeneration and cognitive health alone make it worth a trial run.

If you are interested in looking further into Tru Niagen, we recommend reading more about it in the published trials.

Perhaps you can talk to your doctor or healthcare informer about the findings on NR.

It may be a few more years until we know whether this is the wonder drug it seems to be.

But so far, the evidence seems to say it is.

I don’t know about you, but I am taking the plunge…

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Disclaimer: These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure, or prevent any disease.

AMPK Activator Reviews

7 Best Ampk Activators (2020) | Metabolism-Bosting Supplement

AMPK has documented health properties, but there are over fourteen thousand articles and almost fifteen thousand user reviews on AMPK Activators.

I’ve read most of these reviews and articles. I can’t compromise when I make professional recommendations to clients daily. Now, you have access to all that research on today’s best supplements.

Life Extension AMPK Activator is the best overall in today’s market because it’s based on numerous clinical trials.

Life Extensions is medically proven to improve your health. However, there are other worthwhile supplements that address specific purposes.

Read the article below to find the best AMPK activator for your needs. You will learn how these supplements work and how to use them. You will find all their benefits and side effects and discover real consumer results.

Review Summary:

  • 1. Life Extension#1 Strongest Ampk Activator
  • 2. Takenutritionx
  • 3. Luz
  • 4. LA-3
  • 5. Berberine HCL
  • 6. Dr. Kardashi Premium Berberine
  • 7. Berberine 1200mg HCL Plus Ceylon Cinnamon Capsules

What is an AMPK Activator?

AMPK Activators are compounds that activate AMPK, and AMPK is short from adenosine monophosphate-activated protein kinase.

This enzyme is essential in stabilizing energy homeostasis, so your metabolism works well.

Niacin AMPK helps burn the calories you need according to the energy demand.

What is AMPK

People with metabolic issues or cancer sometimes burn too many or too few calories.

AMPK is a therapeutic target that helps keep chronic metabolic illness or even cancer in check. Ampalive supplement reviews show these results.

AMPK can be obtained from food or quality supplements available on reputable websites like Amazon. You’ll find how to get these options below.

SUMMARY: AMPK Activators trigger the production of AMPK enzymes, which heighten your metabolism. Use AMPK Activators to ensure your cells are in their best health.

7 Best Ampk Activator Reviews (List for 2020)

The supplements below are strong and thoroughly tested. They kickstart your metabolism and address a wide range of issues.

As each person has different needs and medical difficulties, I’ve selected the best supplements for each purpose. I’m sure reading below will help you find the right AMPK supplement.

1. Life Extension – #1 Best AMPK Metabolic Activator

Life Extension AMPK Metabolic Activator

Life Extension AMPK Metabolic Activator is the best choice because you can trust it works. It has the most positive reviews, it’s made by a reputable company, and it is backed by a lot of research.

Each bottle contains 30 easy-to-swallow pills, which:

  • Are made with quality ingredients. The mix of Calcium carbonate, Hesperidin, and Actiponin gynostemma extract is a reliable AMPK activator. Your aging cells will receive new life to better remove old cells, fight infections, and produce more energy. This supplement is clean, vegetarian, and contains no GMOs. However, you may dislike the addition of thickening agents.
  • Help burn fat. The product makes a false claim of burning belly fat, but that is scientifically impossible. Life Extension AMPK helps you burn fat from all over the body. Once your cells’ metabolism is working faster, they will burn more energy. Besides, calcium is known to accelerate fat loss.
  • Improve your immune system. As your cells’ metabolism is hastened, they’re able to fight inflammation better, to replicate faster, and to eradicate sick cells. The result is you’ll lower your risk of chronic illness or infection.
PROS
  • Easy-to-swallow capsules
  • No GMOs
  • Fat loss
  • Rejuvenation of your cells
  • Illness prevention thanks to increased AMPK levels
  • Trustworthy (proven to work in many clinical trials)
CONS
  • Doesn’t target belly fat specifically as advertised

Summary: Life Extension AMPK Metabolic Activator is a quality mix of balanced ingredients that improve your cellular metabolism. Get this supplement and your body will be able to fight illness and burn fat.

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2. TakenutritionxTakenutritionx AMPK Activator Boost

Takenutritionx AMPK Activator Boost has many happy Amazon customers. Chances are you’ll see the same progress with your fat loss and testosterone levels as they did.

Most people agree that taking this supplement increases your stamina. The probability of it working for you is at least 70%, considering the product has a 3.5-star rating on Amazon.

The brand also claims its supplement produces and breaks down sugars, which helps you prevent and manage symptoms of diabetes.

As TakeNutritionx Boost hastens cell metabolism, it also stabilizes your blood circulation and improves cardiovascular health.

  • Gynostemma Pentaphyiium Leaf Extract (450 mg) is clinically proven to boost your energy and strength. This ingredient works well in pre-workout supplements.
  • Quercetin Dihydrate (100 mg) effectively eases diabetes, gastric issues, inflammations, and tiredness. This enzyme is an antiviral, it can prevent cancer, and it also increases your athletic endurance.
  • Berberine HCL (100 mg) controls blood sugar levels, accelerates fat loss, and keeps your heart healthy.
PROS
  • Increased stamina thanks to berberine quercetin and gynostemma
  • Good for diabetes control
  • Energy booster
  • Reduces tiredness
CONS
  • It takes a few weeks to see weight loss results

Summary: Takenutritionx Boost’s mix of ingredients can increase your stamina and diminish fatigue. Although it’s not excellent for weight loss, get this if you need more energy.

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3. Luz

Luz AMPK Activator

Luz AMPK Activator is best if you need a powerful, natural AMPK supplement to reinvigorate you. As your ketone levels increase, you can lose weight faster and keep your diabetes in check.

This product contains the complete dose of all the four AMPK activators you need each day, with high concentration.

The clinical dosage ensures a bullet-like action for your problems.

  • Clean product. Luz contains vegan ingredients, free of gluten, GMOs, and pesticides. Other safe ingredients for you are cellulose and microcrystalline cellulose. These are used to envelop the capsule and for anti-caking.
  • Improves health. The mix of ingredients benefits your mental health, gives you increased energy, and lengthens your lifespan. All the ingredients have clinically-effective dosages for maximum results:
    • Gynostemma 80% on energy
    • Berberine 99% on heart health and diabetes
    • A-Lipoic Acid 99% on brain protection
    • Resveratrol 98% to reduce your age-related cognitive decline and your insulin sensitivity.
PROS
  • Clean ingredients, with no GMOs, allergens, or toxic substances, that are safe for you
  • Backed by quality research
  • The clinical dosage for all ingredients ensures maximum results
  • Best for health and longevity
  • Vegan
  • Increases your ketone levels
CONS
  • Not best for weight loss if you don’t change your diet
  • Mild GI distress the first couple of days

Summary: Luz AMPK Keto has clinically-effective ingredients to improve your health and increase your energy. Get this supplement if you want to lose weight slowly but surely because it will increase your ketone levels.

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4. LA-3 – Boost Energy and Promote Longevity

LA-3 AMPK Activator

LA-3 AMPK Activator has a 3.4-star rating on Amazon, so there’s about a 70% chance this supplement will also work for you. Just like most customers, you will feel more energetic, increase your libido, and notice glowing skin.

  • Increased energy and health. It has the same ingredients and concentrations as Takenutritionx Boost:
    • Gynostemma leaf extract for energy
    • Quercetin dihydrate to reduce inflammation and to increase your stamina
    • Berberine HCl 100 mg for cardiovascular health and lower blood sugar

So just like Takenutritionx Boost, LA-3 AMPK Activator is best for increased energy and sex-drive.

However, other ingredients include Rice Flour, Stearic Acid, and Hypromellose. These are not the best options.

Rice flour is packed with carbs, so it’s not a keto-friendly option. Stearic Acid might have a laxative effect and interferes with the absorption of the AMPK activators.

PROS
  • Good reviews prove it works for most people
  • Quality mix of AMPK activators for safety and good results
  • Increased energy
  • Increased libido
CONS
  • Not for keto dieters (added rice flour)
  • Possible laxative effects, especially as you have to take two capsules on an empty stomach
  • Lower absorption rate than other products

Summary: LA-3 AMPK Activator is not the best supplement for keto dieters. You will notice moderate weight loss effects if you restrict your calories. Get this supplement if you need to improve energy and libido.

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5. Berberine HCL

Berberine

Berberine HCL 500mg by Double Woods Supplement is best for stabilizing your sugar levels and heart health. That’s thanks to a high dosage of 1,500 mg total of Berberine every day.

Berberine is an alkaloid used for millennia in Chinese medicine. Western medicine has also proved its significant effects on insulin-resistant people. This means the supplement is an effective AMPK activator that will most likely work for you.

This supplement is:

  • Increased metabolism. Berberine activates AMPK and stabilizes your blood sugar because it helps your body metabolize glucose faster. This supplement is best for people with PCOS, diabetes, high cholesterol, and those on keto.
  • Weight loss. Berberine stops the production of fat cells at molecular levels. The result is people on a dose of 1,500 mg of Berberine per day can lose a big chunk of their fat weight.
PROS
  • Lower cholesterol
  • Heightened metabolism
  • Stabilized blood sugar
  • Proven weight loss benefits
CONS

Summary: Berberine HCl is best if you have high blood sugar, cholesterol, or obesity. Berberine has shown to improve these conditions, so it will likely work for you.

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6. Dr. Kardashi Premium Berberine

Dr Kardashi Premium Berberine

Dr. Kardashi Premium Berberine works if you have high blood sugar levels. However, it’s not as effective as Berberine HCL 500mg by Double Woods Supplement because:

  • You will get a lower daily dosage aka 1200mg instead of 1500mg
  • You’ll ingest more carbs because it uses rice flour as a thickening agent
  • You may not absorb it completely. This product uses Magnesium stearate which prevents the absorption of dietary supplements
PROS
  • GMO-free
  • GMP-certified
  • Stabilizes high blood sugar
  • Lowers cholesterol
  • Keeps weight in check
CONS
  • Not very effective if you are already obese or with full-blown diabetes

Summary: Dr. Kardashi’s Premium Berberine has quality ingredients, but moderate dosages. Get this product if you want to stabilize your weight gain and stop your pre-diabetes from evolving.

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7. Berberine 1200mg HCL Plus Ceylon Cinnamon Capsules

Berberine 1200mg HCL Plus

Berberine 1200mg HCL Plus Ceylon Cinnamon Capsules has an excellent 4.7-star rating on Amazon, so there are 94% chances it will work for you.

Most people agree this supplement helped them control their blood sugar in a natural way, with no artificial ingredients. The probability is high to also get these results. You’ll appreciate the affordable price and high-quality berberine.

Each capsule has 450mg Berberine HCL and 150mg Ceylon Cinnamon. The daily dosage is maximum of two capsules per day, which means:

  • You’ll get less Berberine than with the previous two supplements, so these pills are best for diabetes and obesity prevention, not treatment.
  • It’s effective. Ceylon Cinnamon increases supplement absorption. This ingredient is also known to improve the health of your digestive system, immune system, heart, and metabolism.
PROS
  • Maximum potency
  • Third-party testing to ensure it works
  • Stabilized blood sugar
  • Increased absorption through the use of Ceylon Cinnamon instead of Magnesium Stearate
  • Anti-inflammation
  • Active PK FDA and GMP-certified facility
  • Vegan
  • Non-GMO
CONS
  • Not very powerful

Summary: Berberine 1200mg HCL Plus Ceylon Cinnamon Capsules is good if you have slightly high blood sugar or if you’re slightly overweight. If you don’t need immediate medical interventions, try this nature-inspired supplement first.

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SUMMARY: The brands in this review address different purposes and needs. Some supplements are better for weight loss; others are best for energy and sex-drive. Some supplements can treat diabetes and high cholesterol, while others can simply prevent these problems. Keep your purpose in mind and consult your GP before choosing your AMPK-activator supplement.

AMPK Activator Ingredients

The supplements above include different ingredients. Choose the one that fixes your thing. Research the ingredients and dosages of all the supplements before deciding. It’s even better to discuss things with your GP.

Main Ingredients

Some of these ingredients include:

  • Calcium carbonate is best for your bone and heart protection, but it also helps your body burn fat stores.
  • Hesperidin has anti-inflammatory properties and improves your blood circulation.
  • Gynostemma Extract is a natural extract that increases your stamina and endurance.
  • Quercetin Dihydrate stabilizes your blood sugar and helps you fight fatigue.
  • Berberine HCL is best against your high sugar levels and high cholesterol.
  • A-Lipoic Acid protects your skin from aging, improves symptoms of diabetes, including neuropathy, improves your cardiovascular health, and reduces your obesity.
  • Resveratrol improves cellular metabolism and rejuvenates your cells. This compound keeps you healthier altogether, plus improves your mental health and clarity.

Pro tips:

  • If your goal is to lose weight, choose a supplement that includes Gynostemma Extract and Quercetin Dihydrate.
  • Choose a Berberine-based supplement if your sugar levels are high.
  • If you’re on keto, make sure your supplement doesn’t include extra sugar.
  • A supplement with clinical dosages can increase your ketone levels.

SUMMARY: Choose your AMPK supplement depending on your needs. Read the ingredient list and their dosages before deciding, and consult your GP.

How to Take. What Does AMPK Do?

Each of the supplements above has different recommendations on how to take them. Some supplements require up to three dosages, like Berberine HCL 500mg by Double Woods Supplement, while others require one dosage.

You might be required to take the supplement on an empty stomach, or with your food.

  • Consult your GP and read the label carefully.
  • Don’t take more than the recommended daily dosage.
  • PharmacyIf you take the supplement correctly, the AMPK activator will do its job. AMPK is an important enzyme that regulates your energy balance, making sure you’re burning the right amount of energy and metabolizing all your calories.

Is Active PK a gimmick? Not at all. Here’s how it works:

  • AMPK is found throughout your body, from the brain to your muscles, liver, and fat cells.
  • AMPK enzyme contributes to the birth of ketones, aka ketogenesis. The result is that your body metabolizes sugar faster to reduce insulin sensitivity, and hastens your metabolism.
  • AMPK inhibits the synthesis of cholesterol, triglycerides, and lipogenesis. AMPK, therefore, reduces bad cholesterol and raises good cholesterol levels.

SUMMARY: AMPK increases your cell’s metabolism so they can do their job called homeostasis. Cells stay younger for longer, but they can also identify and fight attackers aka pathogens and their effects. AMPK regulates your hormones and makes sure sick cells are killed faster.

What Are the Side Effects of AMPK / Major Benefits From Taking

If you’ve read this far, you already know a bit about the benefits and side-effects of AMPK. Remember, though, that all these advantages and possible inconveniences depend on the ingredients and their dosage.

Not all AMPK activation supplements behave the same, but most have only mild side-effects.

From that point of view, they’re much better than Phenocal, which acts fast against obesity but causes severe vomiting and pain.

Benefits include:

  • Reduces your cholesterol
  • Increases your fat burning process to lose weight faster
  • Improves your stamina and energy
  • Increases your sex drive and testosterone levels
  • Stabilizes your blood sugar levels to avoid or reduce diabetes
  • Improves your circulation, which lowers your risk of cardiovascular issues
  • Decreases chances of diabetes and obesity
  • Helps you control your weight
  • Lower your risk of chronic illness like cancer or inflammation
  • Help to reduce the effects of aging (anti-aging properties)
  • Heightens your metabolism
  • Stabilizes your hormonal system

AMPK Supplement side-effects include:

  • You may notice slight GI distress depending on ingredients and dosage.
  • PPAR gamma and alpha proteins’ suppression in the long-term. These proteins are involved in stabilizing your blood sugar levels and liver health. They might also decrease your body’s ability to actively prevent atherosclerosis.
  • If you eat unhealthy fats and lots of sugar, absorption is repressed, so the supplements might not work as well.

Some supplements have more intense side effects, which require you to consult with your GP. For example, Sletrokor Diet Pills reviews show that not everyone can take this supplement safely.

SUMMARY: Most of them are marketed as fat-burning, weight-loss miracle pills. Although AMPK has many benefits for your general health, it can also trigger some GI side effects in the short-term.

What Foods Are High in AMPK? Activator Alternatives

If you want an AMPK activator alternative, consider eating more AMPK-rich foods, which are all-natural. Eating clean is always a good idea but might not be enough if you already have serious health issues or if you’re older.

Foods Are High in AMPK

Diet is a good prevention measure but can ease existing symptoms only in combination with doctor-prescribed medication.

That said, AMPK foods are:

  • Apple Cider Vinegar
  • Bark extract
  • Bilberries
  • Blueberries
  • Cinnamon
  • Extra-Virgin Olive Oil
  • Fish Oil
  • Ginseng
  • Grapeseed
  • Green Tea
  • Red Grapes
  • Soybeans
  • Turmeric
  • Vitamin E

SUMMARY: Good alternatives to AMPK Activator supplements include foods rich in antioxidants, healthy fats, and substances such as resveratrol. These foods have been used in homeopathic and Eastern medicine for millennia. However, quality supplements like the ones above have higher dosages. This means they’re more effective for curing rather than prevention.

Does AMPK Work for Weight Loss?

Some studies show that AMPK can assist in weight loss because it increases your metabolism. You’ll burn calories at a faster rate and burn more fat because it promotes ketogenesis.

For instance, Nucific Deep Cell Activator reviews show this is effective for your weight loss.

Burn Calories Faster

AMPK doesn’t help you lose weight unless you eat a balanced diet of healthy foods:

  • Trans fats and processed sugar prevents AMPK absorption
  • Stepping too much over your daily caloric limit means some of those calories will be stored as fat

Exercise activates AMPK even more. Use your extra energy and endurance to burn off those extra pounds, or you’ll become agitated and have sleep issues.

SUMMARY: AMPK heightens your metabolism and helps you lose weight, but it’s not a metabolic magical bullet pill against obesity if you don’t eat healthily.

Consumer (Customer) Reviews & Results

Amazon and other forums are filled with divergent customer reviews and results with various supplements.

These people have tested at least one AMPK supplement before writing their opinion. Unsurprisingly, some say AMPK Activators work, while others say they don’t.

AnnaDisgruntled customers claim they see no effects, but you don’t know their diet plans or severity of health issues. Some LCR Active PK reviews from people like Mary A. Cleaves and Anna show you also have to diet and exercise.

Customer reviews show that:

  • The supplements reviewed here have 3.5-4.5 star ratings.
  • Most people who’ve reviewed these supplements negatively either:
  • Some supplements are indeed low-quality because:
    • They don’t have the necessary dosages to work.
    • They contain ingredients that mess with its absorption.

That’s not the case with my list of products. Read a Sletrokor diet pills review to see how much people disagree.

  • Some supplements like LCR Health Active PK don’t have enough reviews on Amazon to decide if it works or not.

SUMMARY: Consumer reports and user reviews are often contradictory to supplements. If you want a good supplement, ensure it has at least a 3-star rating on Amazon. Ensure the people who speak badly of the supplement have taken correct dosages and purchased the right supplement for their needs. Users do not have the same results all the time because of different body structures, so get a proven supplement like Life Extension.

Final Words. Which AMPK Activator to Choose?

Choose the AMPK Activator that fits your profile and needs; otherwise, chances are it won’t work. Each of the products in this review is best for a certain purpose, and all of them have good ratings.

  • Takenutritionx Boost’s mix of ingredients can increase your stamina and diminish fatigue, but it’s not excellent for weight loss. South Beach Sciences Ampalive reviews show this supplement is better for losing pounds.
  • Luz AMPK Keto has clinically-effective ingredients to improve your health and increase your energy. As the ingredients stabilize blood sugar and increase ketone levels, this product can help you lose weight slowly.
  • LA-3 has moderate effects on energy and libido.
  • Berberine HCl is best for people with high blood sugar, cholesterol, or obesity
  • Dr. Kardashi Premium Berberine prevents you from gaining weight and is good for people with pre-diabetes.
  • Berberine 1200mg HCL Plus Ceylon Cinnamon Capsules is good for people with slightly high blood sugar or slightly overweight, who don’t need immediate medical interventions and want to try a nature-inspired supplement first.

BUT:

Life Extension AMPK Metabolic Activator is the best choice because it has the most positive reviews, it’s made by a reputable company, and it is backed by a lot of research.

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Choose this supplement because it can alleviate a multitude of your symptoms, such as tiredness, neuropathy, and weight gain.

Take advantage of its properties and order it now!

Dr David Sinclair

David Sinclair Supplements (2020) | NMN, Metformin, Resveratrol For Anti-Aging!

David Sinclair gained a lot of popularity with his recent appearance on the Joe Rogan Experience, especially as he discussed such a poignant topic as life extension.

But is anti-aging something we can consider?

Can we fight death?

Not exactly. We can fight the negative effects of aging; we can look younger, and feel better for longer periods of time.

That’s David’s promise.

David SinclairDavid is a Ph.D., A.O. professor in the Department of Genetics and co-Director of the Paul F. Glenn Center for the Biology of Aging at Harvard Medical School, David A. Sinclair is a pretty busy man, considering he’s also cofounded seven biotech companies, plus he’s the co-chief editor of the Journal Aging.

In the latest news, Sinclair, along with other European and US researchers have established the Academy for Health and Lifespan Research.

And, although he’s 50 years old, his biological age is 31.

His antiaging research, his energy, and focus, plus his appearance could convince anyone that what he’s saying is legit.

However, remember to consult your GP before trying anything because all these products may interfere with pre-existing conditions.

RECOMMEDATION (Good For Daily Energy & Longevity)
There are only a Few Leaders in this Market Segment ( . & .). . is the ONLY Legal Distributor. Product is Tested for Safety & Efficiency.

In My Personal Experience & According to Countless Anecdotal Evidence – It Provides Energy and Vigor Throughout The Day & Scientifically Shown to Raise NAD Levels. Now. (.).

  • 100+ Preclinical Studies
  • NIAGEN was successfully reviewed under the FDA’s new dietary ingredient notification program (NDI)
  • 20+ Owned and Licensed Patents

What is Dr. David Sinclair is Takin to Prevent Aging?

David Sinclair takes 1 gram of NMN and 0.5 g of resveratrol in the morning mixed in with yogurt; Studies showed that resveratrol absorption was 5 times lower if without fat. He doesn’t mention a specific brand David takes the products below. He does take the resveratrol leftover from clinical trials. He prescribed some of these molecules to his mom and dad too, and even his family dogs!

Below are 3 longevity supplements David takes: Resveratrol, Metformin, NMN, and more…

NMN

Tru Niagen Nicotinamide Riboside

NMN and Nicotinamide Riboside elevate your NAD levels. (Tru Niagen is The Best Replacement for MNM, it considered to be more effective in raising NAD levels. I recommend considering Tru Niagen (Nicotinamide Riboside) products instead of NMN)

NAD helps your body make more energy. When you age, your cells make more NAD.

So not only do you feel more tired, your cells can’t function properly because they don’t have the energy they need.

That’s why David advocates supplementing with NMN to increase your NAD levels, even though there’s no scientific consensus on this either.

NAD Levels

David mixes his NMN into yogurt, so you need to find a powdered version.

Alive By Nature NMN Sublingual Powder is one of the best NMN powders on the market. It’s 100% natural and vegan, with over 99% purity, no GMOs, and no gluten.

It works better if you place it under your tongue, though. The belief is that way the NMN can enter your bloodstream immediately, bypassing the liver, although this approach isn’t fully researched yet.

The only downside is that quality NMN like this one is quite expensive, especially if you want to take 1g/ daily like Dr. Sinclair.

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Resveratrol

Resveratrol

Remember how everyone used to be hyped about red wine? That’s because of all the resveratrol found in the grape peel.

It was assumed that because grapes have this anti-aging substance in their peel, you can drink red wine and you’ll live a longer, healthier life.

Now we know that’s not the case because you’d have to drink hundreds of bottles of wine per day for resveratrol to work.

That’s how concentrated resveratrol supplements emerged. That is controversial, but we’ll discuss that below.

RevGenetics M98 MicronizedIt’s important to note he has been taking resveratrol for over a decade. One of the perks of being a scientist is having all that extra resveratrol from the time of lab experiments.

We, the plebe, have to look on Amazon. To make sure you get a product that’s similar to what he is using, you can read a paper published by one of his companies, Sirtris Pharmaceuticals, which was testing micronized resveratrol.

Micronized resveratrol increases the blood resveratrol levels almost four times.

As per these podcasts notes at Rich Roll, he recommends RevGenetics M98 Micronized Resveratrol. This is a legit company that has been selling resveratrol supplements since the early 2000s.

This product is micronized, so the molecules last longer in your bloodstream.

The powder form is user-friendly, as you can mix it with your shakes or yogurt.

With a 98% purity and high potency, the only downside of this supplement is how much it costs.

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Vitamin D with K2

Vitamin K2 + D3

Vitamins D3 and K2 are both involved in proper calcium absorption in your body. That way, calcium can go straight to your bones instead of blocking your arteries.

Sports Research Vitamin K2 + D3 with Organic Coconut Oil is one of the best choices that I discovered.

Made with Coconut OilEach capsule contains 5000 iu Vitamin D3 and 100 mcg Vitamin K2 in Menaquinone-7 form.

These concentrations mean that each capsule is very potent and efficient.

Keep in mind that the DRA for vitamin D3 is 600-800 iu per day, but vitamin D3 is easily excreted through the urine, so you need a bigger supplementation.

Even so, consult your GP before taking a D3 supplement, especially if you have pre-existing conditions.

Your GP might prescribe anywhere between 1000 iu to 5000 iu daily.

That said, this supplement:

  • Is efficient for protecting your bones and heart
  • It gives you an energy boost
  • Non-GMO
  • Vegan-certified
  • Derived from top-quality ingredients (Vitamin D3 from lichen and MenaQ7 Vitamin K2 from chickpea)
  • The Tapioca soft gel capsule makes it easy to swallow
  • It has easy absorption because it’s mixed with coconut oil
  • 90-day money-back guarantee
  • Easy to swallow

The only con is possible bloating, but that’s just the effect of D3. This supplement from Sports Research causes fewer GI problems than other D3 supplements on the market.

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Metformin 1g Daily

Metformin

Metformin is not a new appearance in the pharmaceutical market. Medical practitioners have known about metformin for a century, and they began studying it in the 1950s.

A plant-based drug, metformin is extracted from French Lilac, and it’s used in managing diabetes, considering it can decrease blood glucose.

Considering that metformin has all the advantages, and none of the risks, it’s no wonder that it looks appealing to fight ageing.

All the other anti-aging products are nowhere near this tested and with so much patient-related data.

Can metformin fight old age?

Metformin is involved in the AMPK cellular pathway activation, which leads to:

  • Better protein synthesis
  • Faster lipid metabolism, including cholesterol synthesis
  • Faster glucose metabolism, including their genesis, synthesis, and breakdown
  • Redox regulation. Manages the protein involved in cell death and survival so good cells can leave, and unhealthy ones can be eliminated.
  • Anti-inflammation. Fighting free radicals and oxidation is a good way to prevent various chronic illnesses, including cancer.
  • Mitochondrial genesis and autophagy. Mitochondria are the powerhouse of the cells, so making more of them increases your metabolism. Mitochondrial autophagy is an essential control mechanism that gets rid of the unhealthy cells in your body, and it has an essential effect in various disorders.

Metformin can improve your metabolism, keep your cells healthy, and eliminate the unhealthy ones.

However, metformin is a prescription drug, and most doctors prescribe it only for type 2 diabetes, not for general health and longevity.

Dr Peter Attia write on metformin and exercise. Really interesting.  Do not take it the same day / time as your exercise!!!

Statin

Statin

In a podcast with Joe Rogan, he says he’s been taking statin since his twenties because he has high cholesterol in his family.

Statins are prescription drugs that:

  • Are the most efficient in lowering your bad cholesterol.
  • They stabilize the blood vessel lining and lower the risk of heart attacks.
  • They reduce the risk of narrow arteries.
  • Statins fight inflammation.

Side effects include:

  • Nausea
  • Vomiting
  • Muscle and joint pain
  • GI distress

These side effects are more common for over 65-year-old females and people with diabetes.

Statins interact with grapefruits, which block certain enzymes that help your body metabolize statins.

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What is the NMN Supplements’ Benefits and Dosage?

Dr. Sinclair explains how NMN supplements work in a Joe Rogan Experience podcast.

He explains that diseases and age-related deterioration are caused by certain genes, called sirtuins.

NMN (nicotinamide mononucleotide) is a type of molecule that activates sirtuins, meaning NMN supplements can prevent disease, give you more energy, and reduce the negative effect of aging.

NMN boost NAD levels, and sirtuins need NAD to work properly.

Benefits and Dosage

NAD, aka nicotinamide adenine dinucleotide, is a coenzyme that assists your metabolism, so your cells have more energy to function and to fight diseases.

People can’t take NAD directly because it’s a larger molecule that can’t be metabolized easily. NMN is smaller, so it’s easier to absorb.

David has been taking 1g of NMN/ day for the last three years.

Studies show that the risk-free dose is 1-2g/ day. Some side-effects can include mild GI distress, tiredness, and light headaches.

Benefits:

What is David Doing Himself To Prevent Aging?

Apart from taking all of the products mentioned above, David does intermittent fasting. He mentions both on his blog and in his book called Lifespan: Why We Age—and Why We Don’t Have To that you can live longer if you don’t overeat.

He believes that old age is a disease that can be treated through nutrition. Intermittent fasting and calorie restriction improve your metabolism.

Calorie Restriction And Fasting

As such, your cells have more energy to keep the healthy ones alive and to kill the unhealthy ones. Accelerated metabolism also reduces inflammation and oxidative stress, which have been linked to chronic diseases.

David also exercises frequently:

  • He runs a couple of times per week, at high intensity on a U-shaped Assault Treadmill.
  • Boxes.
  • Lifts weights.

David recommends using sauna and cold baths together, to accelerate your metabolism and improve heart function.

Other Supplements David Sinclair Takes

While David generally tries to get all the vitamins and minerals he needs from his diet, he does still take some supplements daily. Specifically, he’s talked about taking:

Vitamin D3

In David’s book ‘Lifespan’, he mentions taking vitamin D3 daily. Vitamin D is a vital micronutrient and is thought to exercise an important effect on at least 200 of our genes. It’s relatively scarce in foods, and so we rely on sunlight for producing adequate quantities. If you’re not getting much sunlight, then it can be necessary to supplement it.

David doesn’t name on the record what brand he uses, or how much he is taking, he discusses in the podcast with famous Dave Asprey that he needs 2,000iu per day at the minimum.

Vitamin K2

David suggests taking Vitamin K2in his book.

Vitamin K is a crucial micronutrient that performs a vital role in the capacity to form blood clots and to move calcium throughout the body. It comes in two various forms, K1 (phylloquinone) and K2 (menaquinone). K1 is the most plentiful in a western diet, found in leafy green vegetables. Vitamin K2  is located in fermented foods, which are less prevalent in a western diet. A source that’s unusually high in K2 is fermented soya beans.

Sadly, many people are low in K1, and hence may have low levels of K1 to maintain sufficient calcium transport

So where does the vitamin K2 supplementation come in?

Vitamin K1 is used in the liver, K2 appears to be prioritized for use in the periphery, which will support calcium transport.

Alpha Lipoic Acid

David suggests taking alpha-lipoic acid. Not to be confused with alpha-linolenic acid – that is a source of omega-3 fatty acids, frequently found in seeds. Alpha-lipoic acid is found naturally in a specific food, and when ingested, is used in the cells as a cofactor in mitochondrial energy metabolism.

CoQ10 (Coenzyme Q10)

David states in the interview with David Asprey that he gets Coenzyme Q10 due to the fact that he is taking statins. He doesn’t explain why he takes  Q10, but he’s likely referring to a study that proposes that statins may decrease coenzyme Q10 levels in the blood. He just states that he gets a large pill daily. Q10 supplements are generally taken in the 100 to 200mg range.

What Does David’s Diet Look Like?

David’s diet is shaped after his caloric restriction principle. He also avoids foods that impact metabolism and affect the glycemic index.

  • David skips one or two meals each day.
  • He stays away from processed sugar and carbs.
  • He only drinks one cup of coffee per day one time in the morning
  • He limits his meat consumption, particularly red meat because certain molecules in meat like Trimethylamine N-oxide – TMAO are correlated with cardiovascular problems. He also believes that the high amino acid levels in meat are dangerous.
  • He occasionally eats fish and chicken.
  • He eats all the veggies he can get.
  • He believes that time-restricted eating impacts your longevity, so he sets a limited period during the day to eat.
  • He prefers eating at night.

What is NAD+ and Why is it Important?

As we’ve mentioned before, NAD is a helper molecule that fuels some of the most important biological processes in your body, like:

  • Metabolizing food
  • Repairing DNA
  • Strengthening cells immunity
  • Stabilizing your internal clock

NAD levels plummet with old age. Very low NAD levels are correlated with Alzheimer’s, diabetes, cardiovascular issues, and vision impairment.

That’s why taking NAD precursor supplements like those manufactured by Metro Biotech can help you age gracefully.

What Does Resveratrol Do to Your Body?

Resveratrol For Your Body

In the words of David, “resveratrol steps on the accelerator pedal of the sirtuin enzymes.”

In the same JRE podcast cited above, David explains that there are plenty of mice studies that show resveratrol improves their health / longevity and lengthens their lifespan.

David says that you need NMN for resveratrol to work because NMN is the fuel that sirtuins need. You can’t “accelerate” sirtuins if they don’t have enough energy to work.

Does Resveratrol Really Work? Is it Safe?

Yes, the medical consensus is that resveratrol is safe.

However, there’s no consensus on whether or not it works.

In 2006, he co-wrote a paper on the benefits of resveratrol.

Other studies emphasize certain concerns around resveratrol’s efficacy, such as:

  • Research hasn’t found the best formula for resveratrol pills to optimize absorption.
  • The claims that resveratrol can reverse the effect of aging, cancer, and obesity are far-fetched because some studies show that resveratrol works, while others show it doesn’t.
  • David’s  net worth is huge because Resveratrol pills yield $50 million/ year, so promoting resveratrol pills poses ethical issues.

Final Thoughts

The research on most of the products that David takes lacks consensus.

Some might even be dangerous for people with certain pre-existing medical conditions (like kidney failure or diabetes), while others can’t be mixed with certain foods (statins and grapefruit).

David PHD SinclairYou should always consult your GP before taking any supplements to find the right dose for your needs.

That said, it’s obvious that David Sinclair believes in these supplements.

Although he’s 50+, he has the biological age of a 30-year old.

His mother, Diana Sinclair, has lengthened her life with two decades by taking the molecules he prescribed, after removing one lung to fight cancer.

His father also takes these molecules, and he’s active and fit as a fiddle at 80.

So do these supplements work? They may, but they need to be tailored to your needs by a medical practitioner.

For more info on lifestyle changes and modifications (fasting, sleep optimization, healthy diet ) – see post on Dr Rhonda Patrick’s Diet

 

Best Sulforaphane Supplement

7 Best Sulforaphane Supplements (2020) | Does It Work or NOT?

My ten-year-old niece is autistic and has difficult-to-manage symptoms. She has few friends because she’s not comfortable with touching and jokes.

I started researching the advantages of sulforaphane as soon as I found out that this substance has similar effects to resveratrol on autism.

My niece is now happier and more adapted, plus I’ve discovered how to include sulforaphane in my diet, how to help my family, friends, and my clients.

I’ve recommended supplementation that includes active myrosinase to clients who’ve complained about joint pain, difficulties coping with post-cancer recovery, weak immune systems, and skin issues. All of them are now happier and healthier, and so can you.

Read the article below to find out which the best supplementation is. I’ll tell you all about this substance’s side effects and benefits, how it affects the liver, and how you can increase your daily intake. Read along!

Review Summary:

  • 1. Avmacol
  • 2. Thorne Research Crucera-SGS
  • 3. BroccoMax
  • 4. Source Naturals
  • 5. BrocElite Plus
  • 6. Best Naturals
  • 7. Swanson

What is Sulforaphane?

Sulforaphane, aka broccoli sulfur, is a powerful chemical compound in cruciferous vegetables. It is an isothiocyanate hydrolyzed from glucosinolate glucoraphanin when the enzyme myrosinase is present. This enzyme activates when you chew, cut, or squash these cruciferous veggies.

Sulforaphane

Every time you chew a piece of broссoli or cabbage, you activate this almost magical-like potion that has been shown to decrease the risk of cancer cell growth, to fight against dangerous inflammation, plus to boost your heart, gut, and brain care. It suppresses and blocks the activation of transcription factors such as NF-Kappa B. One thing that keeps popping up in these studies as a significant factor in the development of cancer is how often people eat cruciferous vegetables. I wasn’t really a fan.

The content of foods varies depending on what you eat. Cruciferous vegetables have the biggest amount.

If you’re wondering how much sulforaphane in broссoli you can eat, one cup of it has 30 mg.

SUMMARY: It is a chemical compound found in cruciferous vegetables with plenty of effects on your brain care, digestive system, and bones.

7 Best Sulforaphane Supplement (List for 2020)

The first two brands in this beginner’s guide have been part of various clinical trials to attest to their effectiveness, which is why I trust them the most. The other five brands are quality and with good ratings on Amazon and other forums.

Choose the nutrition you need depending on your purpose. Consider the concentration, the high-grade ingredients, and whether certain nutrition fits your lifestyle.

1. Avmacol Production System (SPS) – Extra Strength

Avmacol

Avmacol is a doctor-developed supplementation as Dr. Brian Cornblatt from Johns Hopkins contributed to the research.

Dr. Cornblatt has spent ten+ years in the study, and Avmacol Immune has been shown to work in a series of clinical studies, including in a 2018’s research regarding autism in kids.

  • Avmacol has another stellar endorsement from the famous Dr. Rhonda Patrick (video, books), who finds that Avmacol autism is the top substitute for sprouts.
  • Healthy ingredients. Avmacol is a combination of broссoli and sprout extract, plus vitamin C and wasabi for added micronutrients. This product has no gluten, and the easy-to-swallow capsules have BPA-free packaging.
  • 35% bioavailability. Avmacol reviews show this is a strong product because the broссoli-derived ingredients contain glucoraphanіn, the enzyme that helps you produce more.
PROS
  • Increased bioavailability
  • Extensively tested in clinical trials
  • Devised by top scientists
  • Filled with micronutrients
  • Easy to swallow
CONS
  • Shorter bioavailability

Summary: Avmacol is developed together with a reputable scientist from Johns Hopkins and has proved its worth in several clinical studies. This product contains top ingredients, and it’s one of Dr. Rhonda Patrick’s top choices. If you decide to make a purchase, I may make a small commission at no additional cost to you.

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2. Thorne Research Crucera-SGS Antioxidant

Thorne Research Crucera-SGS

Thorne Research has also proven its worth in clinical trials and has the backing of reputable institutions such as Johns Hopkins University, Mayo Clinic, and a dozen US sports teams.

  • Clean ingredients. This product is gluten-free; it has no artificial colors and preservatives, nor GMOs. The main ingredient is 50mg glucosinolate.
  • The equivalent of two-pounds of cooked brocoli, according to the official slogan. However, this product has no myrosіnase, which means it has a lower anti-bacterial bioavailability, most likely 10%.
PROS
  • Produced by a trusted brand
  • High-grade ingredients
  • Backed by top institutions
  • Involved in plenty of clinical trials
CONS
  • Low bioavailability

Summary: Thorne Research is a trustworthy brand that has proved its worth in various clinical trials from Johns Hopkins and Mayo Clinic. It has clean ingredients, but a short bioavailability.

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3. Jarrow Formulas BroccoMax – Supports Liver

Jarrow Formulas

Brocco Max is made by a German company with a good reputation in the world of fitness supplementation. It uses clean ingredients, and its brocсoli supplements are made in a cGMP facility, meaning they’re tested rigorously for purity, strength, and high-grade.

  • Good formula. The veggie capsules are brocсoli-based. They contain 30 mg glucosinolate extracted (without solvents) from broccoli seeds, as well as myrosіnase and calcium ascorbate. These hypoallergenic pills have no traces of soy, gluten, eggs, dairy, fish, or nuts.
  • Around 35% bioavailability. The combination of 30mg glucosinolate and myrosіnase ensures you get a good bioavailability. However, the blend is proprietary, and you can’t know this figure for sure.

And the ingredients are encapsulated for delayed release

PROS
  • Vegetable formula
  • 30mg glucosinolate
  • Hypoallergenic
  • Easy to swallow
  • Safe and quality-tested
  • Good Broccomax hair loss reviews
CONS
  • The new formula contains carb-filled rice maltodextrin
  • Some people have complained of mild stomach pain

Summary: BroccoMax is a reliable combination of glucosinolate and myrosіnase. This effective product boasts top ratings from happy customers.

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4. Source Naturals

Broccoli Sprouts

Source Naturals gets its inspiration from nature, and its Broccoli Sprouts tries to mimic the natural composition of brocсoli.

It is a research-backed supplement, devised with organic ingredients, and no GMOs. This product is top for people who undergo a cleanse or detoxification and need additional liver maintenance.

  • 2,000 mcg. Although the enzyme intake is five times higher than your average serving of brocсoli, the lack of myrosіnase enzymes means this product has a shorter bioavailability of around 10%.
  • Clean, hypoallergenic ingredients. This product contains organic, non-GMO ingredients, although you might see some thickeners on the list of ingredients. However, it has no yeast, dairy, eggs, gluten, soy, wheat, sugar, artificial colors, and aromas.
PROS
  • Contains calcium
  • Natural
  • Hypoallergenic
  • Effective for liver
  • Good against pain
CONS
  • Shorter bioavailability

Summary: Source Naturals is an organic, GMO-free product. The glucosinolate and calcium form is effective and healthful.

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5. BrocElite Plus

Brocelite

BrocElite Plus Sulforaphane is top for immune maintenance, joint flexibility, and mood thanks to its Stabilized™ formula.

All these benefits stem from the 5 mg of stabilized formula, which has maximum bioavailability, although it might trigger mild GI distress.

  • 5mg stabilized. You would have to eat five pounds of fresh brocсoli to get this quantity of sulforaphane out of it.
  • Boosts brain. The formula fights inflammation to the brain and brain plaque. Your neurons are stronger and can resist neurodegenerative illnesses.
  • Joint flexibility. SNF blocks the NFKB nerve pathway that increases inflammation, and it activates the NRF2 pathway that fights inflammation. The result is minimal pain and increased mobility.
  • Top ingredients. The beauty list of ingredients includes no gluten, GMOs, artificial ingredients, sugar, carbs, lactose, eggs, fish, or soy. This essential hypoallergenic product is made in the USA with capsules from Canada.
PROS
  • Trademarked formula
  • Good for brain and joint mobility
  • Top ingredients
  • Maximum bioavailability
CONS
  • Some GI distress

Summary: BrocElite Plus is a good choice for people who want increased mobility and reduced pain, according to multiple happy customers.

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6. Best Naturals

Broccoli Best Naturals

The Best Naturals Broccoli Sprouts Extract is an affordable, high-grade product that lasts you the whole month for less than $13.

Each serving contains 1000 mg, standardized to 6% glucosinolates, and 0.3% sulforaphane.

  • Clean ingredients. The only 1 ingredient in this product, with some safe thickeners like gelatin, silica, and vegetable stearate. The capsules have no artificial colors, sweeteners, flavors, preservatives, eggs, soy, or other allergenic ingredients.
  • Safe and effective. This product is made in the USA. It has a GMP certification, and it’s been third-party tested for purity, potency, and freshness. Many customers have seen its effects, including decreased blood sugar levels and fewer episodes of heartburn.
PROS
  • Affordable
  • Clean ingredients
  • Hypoallergenic
  • USA-made
  • GMP-certified
CONS
  • Short bioavailability (no myrosіnase)

Summary: It is excellent for people who need an affordable product because they don’t eat enough cruciferous veggies.

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7. Swanson

Swanson

Swanson Sulforaphane from Broccoli is top to maintenance liver because it protects you from oxidative stress and toxicity. This vegetarian product uses clean ingredients, although some people might frown on the addition of thickeners.

  • 400 mcg . Although this product contains the equivalent you’d get from one serving of brocсoli sprouts, it also contains no myrosіnase. The result is shorter bioavailability, but some people have noticed good results with symptoms of autism and skin problems.
  • Clean and vegetarian formula. The capsules contain just brocсoli sprout concentrate, rice flour, and hypromellose for the vegetable capsule. The product follows all the GMP guidelines.
PROS
  • Good ingredients
  • Clean formula
  • Trustworthy company
  • GMP-certified
  • Third-party tested
CONS
  • Not the most effective supplement

Summary: Swanson is a clean product with plenty of positive reviews for its efficiency. The pills are rigorously tested, but some people are skeptical about their performance, considering the reduced quantity.

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SUMMARY: These sulforaphane supplements are devised by trustworthy brands and have documented healing properties. Many happy Amazon customers attest to their worth, and their effectiveness is reflected in the list of ingredients.

What Are the Health Benefits of Sulforaphane? Any Side Effects?

Foods with sulforaphane have been proven effective against a wide array of illnesses because this substance boosts your levels of antioxidants; it decreases inflammation and fights toxicity.

NRF2

It activates the NRF2 pathway against inflammation, which is why it’s such a powerful substance for joint pain, heart issues, and even cancer.

Popular science has praised cruciferous vegetables as a miraculous cancer cure for some time. Apparently, you need as few as three servings per week to reduce the risk of cancer by a third.

Sulforaphane from broccoli and seeds is the most effective. Some studies that ascertain its effects refer to:

It is usually safe and poses no risks because it’s a naturally-occurring substance. Some people have complained about some minor side effects:

The biggest problem with supplementation is the lack of enough human studies to ensure the correct dosage for safety purposes.

SUMMARY: It has been proven effective against cancer, heart, gut, and brain issues. It is a safe compound, but supplementation can trigger some mild GI distress.

Is Sulforaphane Good for the Liver?

It is good for the liver because cruciferous vegetables protect against liver toxicity, and it is naturally found in them.

Liver Foods fight inflammation and remove toxicity.

The benefits of broccoli sprouts include getting rid of toxic substances.

This supplementation increases your antioxidant levels and dissolves airborne pollutants.

Many studies show that vegetables:

SUMMARY: All evidence points that sulforaphane helps the liver get rid of the toxic substances in your body and to protect itself better.

How Do You Increase Sulforaphane?

There are two ways to increase sulforaphane: choosing the supplementation with the biggest bioavailability and eating fresh broccoli.

Bioavailability refers to your body’s capacity to absorb. To ensure big bioavailability:

  • Get enough C6H11NOS2 from your diet
  • Pick a brand with myrosіnase because this enzyme turns glucoraphanіn into it

According to Johns Hopkins University, the bioavailability of supplementation is:

  • 70% pure C6H11NOS2
  • 35% glucoraphanin with myrosіnase
  • 10% only glucoraphanіn

Another way to increase sulforaphane in your diet is to grow brocсoli at home. This is Dr. Rhonda Patrick’s preferred method, although not everyone may have time for it.

Eat Broccoli

Eating your own C6H11NOS2 foods can be your great option, but remember that cooking reduces the strength of myrosinase, so it’s excellent to:

  • Eat raw brocсoli. Cruciferous vegetable sulfur is highest in raw plants.
  • Add raw ground mustard seeds to increase sulforaphane up to four times because these seeds contain all the myrosіnase you need

SUMMARY: You can increase C6H11NOS2 is you buy the supplementation with the biggest bioavailability, consume fresh brocсoli, or add mustard seeds to your cooked cruciferous veggies.

Avmacol vs Broccomax

Does Avmacol working, or is BroccoMax better? It’s important to choose according to your needs, so read this comparison below.

Versus Broccomax

  • Who made them. Avmacol is developed in combination with Dr. Brian Cornblatt from Johns Hopkins and has been proven effective in plenty of clinical studies. BroccoMax is made by a reputable German company called Jarrow in a cGMP facility.
  • Endorsements. Avmacol is endorsed by public figures such as Dr. Rhonda Patrick, but BroccoMax has its supportive customers.
  • Effectiveness. Avmacol is the top vegan supplementation for researchers observed an improvement in behavioral symptoms associated with autism according to a 2018 study, but BroccoMax has been shown to help a lot of people too.
  • Healthy ingredients. Avmacol contains broccoli seeds and sprouts, wasabi, and vitamin C, plus no artificial ingredients. BroccoMax has clean, healthful, hypoallergenic ingredients too, but also rice maltodextrin, which has lots of carbs.
  • Bioavailability. Both vegan supplementation offer about 30mg glucoraphanin in combination with myrosinase, so they have similar bioavailability around 35%. However, Avmacol contains additional vitamin C, which has been shown to increase the bioavailability of dietary supplementation.
  • Healthy ingredients. Avmacol is a combination of broссoli and sprout extract, plus vitamin C and wasabi for added micronutrients. This product has no gluten, and the easy-to-swallow capsules have BPA-free packaging.
  • 35% bioavailability. Avmacol is a strong supplement because the broссoli-derived ingredients contain glucoraphanin, while wasabi is packed with myrosіnase, the enzyme that helps you produce more.

SUMMARY: Avamcol is endorsed by more clinical trials that prove its effectiveness and has fewer carbs than BroccoMax. Both vegan supplementation use high-grade ingredients and have similar bioavailability levels. Check their website.

How to Pick the Right

The first thing to consider when choosing a sulforaphane supplementation is the amount of sulforaphane you will get. This depends on the formula but also on how your body works.

The great supplementation are those who use day-old broccoli sprouts because they’re effective and value-for-money.

How to Pick the Right Sulforaphane Supplements

Broccoli seed extract used in supplementation like Thorne Crucera is the most effective, but it’s also expensive, while mature broccoli plants have the least amount of sulforaphane.

Remember to take into account the supplements’:

  • Bioavailability (I already mentioned it here)
  • Quality ingredients (no GMOs, no allergens, clean ingredients)
  • Manufacturing facility (safety certifications, country)
  • Positive reviews and endorsements (customer reviews, clinical trials, celebrity endorsements)
  • User-friendliness (price, how easy it is to swallow, the customer help)

SUMMARY: Choose the top products depending on your needs. If you have serious problems, pick a supplement with the biggest concentration of sulforaphane. If you don’t have issues, but you feel like you aren’t eating enough cruciferous veggies, you can get an affordable supplementation with a smaller concentration. You can verify our authenticity from various other online resources.

Our Verdict. Are Sulforaphane Supplements Effective?

If you’ve read this article, you know that some sulforaphane supplements are effective, and not all of them can address the same issues.

For instance, BrocElite, with its Stabilized™ formula, is the most powerful supplement in this review. This supplement is good for people with intense pain or chronic issues.

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On the other hand, if you don’t have pressing health problems, but need an affordable supplement because you’re not eating enough green veggies, consider the affordable Best Naturals.

Avmacol and Thorne Crucera (soon to be discontinued) are the top two supplements in this review because they’re devised with high-grade ingredients and have been part in a wide range of clinical trials to prove they work in a series of conditions.

Take advantage of Avmacol’s researched benefits against autism and chronic illness and get it now. In case if you find our data and details misleading or inappropriate, then you are always free to contact us.

Best NAD Supplement Reviews / nicotinamide riboside

Best NAD Supplement Reviews (2020 Update): Legit or Not?

  • If you are someone who curious about Nicotinamide Riboside (NAD precursor that is proven to increase NAD levels) and wondering which of the two available NAD supplements you should be taking. There are only 2 Legitimate Choices: It Is Tru Niagen from ChromaDex and Elysium’s Basis?
  • Two companies are in a patent war with each other, but what you need to understand is that as of now Elysium used to get NR from ChromaDex, and now due to Elysium Health lawsuits they are getting it from unknown sources.
  • It doesn’t mean it’s bad, but if you want the same patent substance used in Nicotinamide Riboside research studies, you will be better off with TRU Niagen (Up to 40% off Right Now). Considering it is also a slightly cheaper route to go.
  • Subscribing into True Niagen seems to be the only viable option (cheaper and more reliable) based on this review (current data).

Let’s find out which is the best NAD supplement…

NAD+ Supplement Review / What is the Best Anti-Aging Supplement?

Now you know everything there is to know about NAD and its precursors. Let’s see if we can get you the best supplement:

#1 Tru Niagen Nicotinamide Riboside

NR from ChromaDexTru Niagen Nicotinamide Riboside is currently the best & most researched product. Let me explain why:

Tru Niagen Ingredients

Each capsule contains 150mg of nicotinamide riboside chloride, and you should take two capsules per serving.

Tru Niagen Nicotinamide Riboside SupplementsAs you know, Nicotinamide Riboside is the most effective NAD precursor, so it has the best chances of being transformed into NAD inside the body.

This supplement is vegetarian; it has no gluten, no nuts, no caffeine, and no artificial colors or flavors.

According to data from the FDA regarding nicotinamide riboside solubility, Niagen is soluble in water.

Other ingredients include microcrystalline cellulose (anti-caking agent, and fat substitute) and Hypromellose (thickening agent and binder).

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Science Behind the Supplement

This supplement has a lot of science backing it up.

There are four different clinical trials published in peer-reviewed magazines which show that NIAGEN® is a safe, effective supplement.

The FDA is On BoardThese clinical trials are based on over a hundred preclinical studies at famous universities like Dartmouth Medical school or the University of Iowa.

The FDA is on board with NIAGEN® too, plus the GRAS certification is there.

ChromaDex, Tru Niagen’s company, has over 20 licensed patents for making and distributing this product.

Besides, there are over 140 research collaborations between this brand and Top US universities, which aim to improve this supplement to make it true youth supplement .

IS There Any Discount Available?

YES!

Currently, you have the chance to save up to 40% if you buy Tru Niagen. This TOP supplement can cost as little as $30, plus you have free shipping in the US.

#2 Elysium Basis Supplement

I’m not really on board with Elysium Basis, and I’ve explained most of my reasons above.

I’ll summarize them here so that you can compare this supplement with Niagen.

Elysium Basis Ingredients

There are two main ingredients in Elysium Basis: 250 mg NR and 50 mg pterostilbene.

Other ingredients include thickeners and anti-caking agents like Microcrystalline Cellulose, Hypromellose, Vegetable Magnesium Stearate, and Silica.

Elysium SupplementThe 250 mg Nicotinamide Riboside are good for their anti-aging effects. But the 50 mg of pterostilbene still makes me want to avoid this product.

Although I took pterostilbene a few years back, before the studies started piling up against it, I wouldn’t recommend it today.

Elysium Health still states that pterostilbene protects you from cellular stress and can improve your metabolism because it activates sirtuins.

Pterostilbene has a similar chemical structure as Resveratrol, plus Resveratrol and coenzyme Q10 have proven beneficial effects against normal aging.

However, pterostilbene also increases bad cholesterol levels. So if you already have cholesterol issues, I wouldn’t recommend this supplement. Otherwise, you could probably take it after talking to your GP about it.

RECOMMENDATION ( For Longevity & Daily Energy)
Even David Express His Doubt Regarding NMN Effectiveness. He Mentioned on a Podcast That Nicotinamide Riboside May Do The Job Better and That is Where . Comes In.

There are only a Few Leaders in this Market Segment ( . & .). . is the ONLY Legal Distributor. The product has been Tested for Safety & Efficiency.

According to Anecdotal Evidence & In My Personal Experience – It Provides Energy Boost Throughout The Day & Scientifically Shown to Increase NAD Levels. Now. (.).

  • 100+ Preclinical Trials
  • 20+ Licensed & Owned Patents
  • NIAGEN was successfully reviewed under the FDA’s new dietary ingredient notification program (NDI)

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Science Behind the Supplement?

This supplement features many studies on its official website to emphasize that it works.

Effects of Normal NAD Levels

A few of them aim to show that pterostilbene is a safe ingredient.

However, these studies have few participants and are short-term.

Other studies show the beneficial effects of normal NAD levels, like better mitochondrial and stem cell functions, along with reduced anti-aging effects.

The downside is that most of these studies are on mice.

Bottom line: the science behind this supplement shows that NAD is beneficial and that NR works, but didn’t convince me about pterostilbene.

Is There Any Discount Available?

Various discounts are depending on your purchase plan. One year prepaid deliveries allow you to save 33%, six months prepaid save you 25%, and a paid monthly delivery saves you 17%.

#3 Life Extension NAD+ Cell Regenerator Nicotinamide Riboside

Life Extension NAD+ Cell Regenerator Nicotinamide Riboside

This is another supplement that many people are referring to, but it is not even worth mentioning. It’s just 100mg dose and cost can go higher compared to other 2 supplements considering the same dosage.

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Elysium Health Include Pterostilbene, Should You Subscribe to It?

Pterostilbene is a compound that makes your body think you’re on a calorie-restricting diet.

As we’ll discuss later, caloric restriction and NDA go hand in hand.

If you take a supplement with pterostilbene, you’ll lose weight faster and accelerate the effect of NDA.

Elysium Health was on board with this NAD+ research from the start, so originally they were the only brand that mixed NR and pterostilbene.

Elysium Health

However, a recent study showed that pterostilbene increases your bad cholesterol levels.

ChromaDex has also stopped commercializing pterostilbene after it’s been shown to increase LDL.

Taking that into account, I wouldn’t recommend any supplement which uses this substance.

Besides, Elysium has had various other problematic ingredients, like trace residue of toluene.

While this isn’t the most toxic artificial ingredient, it’s still a problem that Elysium didn’t disclose it’s manufacturing process to the FDA.

Nicotinamide Riboside Research! Do NAD-Boosting Supplements Have Anti-Aging Effects?

Low NAD levels in the body are known to impair our mitochondrial function.

With age, our NAD levels decline, so does the mitochondrial functionality.

Scientists suggest that increasing NAD levels may delay aging and all the bad deceases that come with it.

What I’m interested in discovering if it is really true and if NAD really may help to delay aging and make us more energetic right away. Is there any product that can help? Possibly!

Anti-Aging Effects

Public interest in NAD has grown in the last few years as research started to pile up looking at the role of mitochondria decline that you can find in numerous age-related conditions and diseases, including Alzheimer’s, diabetes, cancer.

Researchers are reviewing enzymes that are dependent on NAD, particularly sirtuins that seem to be vital in aging.

Nicotinamide riboside (NR) is a form of vitamin B3 (niacin) that is a NAD precursor. It boosts NAD levels and increases mitochondrial function. Some small amounts of NR can be found in some foods, that contain whey or yeast.

Nicotinamide RibosideResearchers into NAD precursors got a surprise when a study by famous scientists, printed in the Cell journal, discovered that injections of different precursorsrejuvenated mitochondria in old mice.

NR is marketed as a supplement called Niagen by a company that has licensed patents from the universities that discovered how to synthesize.

Also, a Nobel Prize winner in Chemistry is on the company’s advisory board.

The existing research shows some convincing results on animal trials.

These supplements are known to increase NAD (nicotinamide adenine dinucleotide) levels in test animals.

Afterward, NAD helps the mitochondria release more energy.

In turn, more energy leads to enhanced DNA repairs and your body working better.

NAD levels decrease with biological age, so that’s why NAD supplements are becoming more popular.

NAD and sirtuins appear after prolonged calorie-restrictive diets, and they’re also linked to Resveratrol.

This molecule is found in the skin of dark grapes and has a potential beneficial effect against aging.

Tru NiagenThat’s why Niagen can sell NR as well as other supplements.

The brand organized a small 6-week trial study you can find in Nature Communications.

The results show that NR can increase the NAD levels in the bloodstreams of healthy older adults.

The catch is that the doses taken by the subjects were double the ones indicated on the label.

While this doesn’t show causation between increased NAD levels and anti-aging, the company awaits FDA approval for its product, which they think can treat Cockayne syndrome.

This genetic disease is rare and determines children to age prematurely.

What Are the Benefits of NAD?

To answer this question, imagine all the risks of decreased NAD levels in the blood.

One consequence is neurodegeneration. Conversely, increased NAD levels can make you more alert, improve your memory and mental clarity.

Decreased NAD levels are also linked to vascular inflammation, increased fat storage in your liver and your adipose tissue, insulin resistance, fatigue and decreased muscle strength.

In turn, normal NAD levels improve the health of your blood vessels, so you’re at less risk for heart issues.

NAD BenefitsNAD decreases dangerous production of fat cells so that you can avoid illnesses such as the nonalcoholic fatty liver disease.

With a normal production and deposition of fat, you can also avoid the risks of extra belly fat.

Normal NAD levels allow your body to consume the extra blood glucose, so you have steady blood sugar levels.

With NAD activating your energy production in the mitochondria, your body will burn more fatty acid, giving muscles an excellent source of energy.

Instead of feeling fatigued, you’ll feel rested and strong.

NAD helps you fight the usual health problems associated with old age so that you can feel, think and act better.

Other NAD Precursors?

There are four NAD precursors you may have heard of:

Niacin

NiacinNiacin is vitamin B3 you can find in flour and fortified milk.

Niacin improves overall cholesterol levels and raises good HDL cholesterol.

This is a safe and affordable product – so what should you be wary of?

Firstly, Niacin can give you flushes. Secondly, Niacin can’t increase NAD levels in your brain or muscles, thus depriving you of certain benefits like cognitive health.

Nicotinamide (NAM)

Nicotinamide, also known as Niacinamide, doesn’t lead to flushing, it’s been around for a while, and it’s not expensive.

Besides, it can increase NAD levels in all tissues.

NicotinamideBut there are two issues with NAM. Firstly, it inhibits sirtuins – remember them from above?

Your body can’t repair your DNA or overhaul your cells without these proteins.

Basically, NAM defeats the purpose of NAD because your cells have more energy, but they can’t use it to repair themselves.

Another issue is that NAM’s results are poorer for older people and obese people.

It can even increase neurodegeneration and can’t reduce bad cholesterol levels.

Nicotinamide Riboside (NR)

Related to B3Your cells can use this molecule that’s related to vitamin B3 to create NAD.

The more stressed or battered your cells are, the more useful NR is to them.

You can find NR in milk, but you’d need to drink 75 gallons for just a dose.

That’s why Nicotinamide Riboside supplements are a good idea. NR doesn’t have any of the side effects above; no flushes, no sirtuin inhibition and no limited availability in your body.

The studies aren’t extremely conclusive, though, and the price is a bit high.

Nicotinamide Mononucleotide (NMN)

NMN is NR with an extra phosphate molecule. However, this molecular addition means that NMN is too big to get into your cells so that it can increase NAD.

Nicotinamide MononucleotideThat’s why your body transforms NMN into NR, which can then replenish NAD levels.

Mice test trials show that’s possible, but the downside is that this process takes longer.

Besides, who knows if your kidneys can effectively get rid of all the extra phosphate?

The extra molecule leads to a price increase, seeing as it’s more expensive to make NMN than NR.

So an NMN supplement costs double than an NR supplement, though it’s five times less effective.

Is Nicotinamide Riboside Safe?

The short answer: yes. The longer answer is eponymous to the name of this article here: Chronic nicotinamide riboside supplementation is well-tolerated and elevates NAD+ in healthy middle-aged and older adults.

This study above is extremely clear to the benefits and safety of taking NR, but there is other research that shows the same thing.

Improving Brain Health

NR can actively increase NAD levels; it improves brain health, makes you livelier, and gives you more energy.

It works for older people; it’s effective and well-tolerated.

Pro tip: The best time to take NAD supplements is in the morning, on an empty stomach.

Nicotinamide Riboside Side Effects

Some people have reported mild to moderate side effects, such as fatigue, nausea, diarrhea, headaches, diarrhea, stomach discomfort and indigestion.

The dosage of 1000mg of NAD+ supplement to 2000mg daily for humans has no dangerous effects. Animal test trials show no harmful effects either.

The only issue is that these human studies are short-term and involve few subjects.

There are no warnings against the use of nicotinamide riboside supplements.

I would like to see more extensive tests with plenty of participants observed throughout a few months or longer.

That said, the current studies show that NR can cause a bit of nausea, headaches, stomach discomfort and tiredness.

Besides, NR doesn’t cause facial flushing like niacin.

Does Niacin Increase NAD?

Yes, but only in your liver and it is not know how much is getting into a cell.

Therefore, niacin supplements – or vitamin B3 – can help reduce bad cholesterol levels.

Niacin doesn’t have other anti-aging results, like improved memory function, more energy, less muscle fatigue or improved cardiovascular health.

How to Increase NAD Levels Naturally

If you don’t think there’s such a thing as a miracle pill, here are some ways to boost NAD+ levels:

You can start a ketogenic diet, which is high in fat and low in carbs, to improve your energy metabolism.

When your body burns fat instead of glucose to get energy, you’re in ketosis.

Increase NAD Levels NaturallyIn ketosis, your NAD+ levels increase, so your body can fight free radicals and slow down the effects of aging.

Intermittent fasting increases NAD+ because you’re restricting your caloric intake, which leads to an increased sirtuin production.

Intermittent fasting is a cell regenerator and boosts your metabolism, unlike traditional calorie-restrictive diets.

Oxaloacetate is another way of increasing your NAD levels because it transforms into malate in your body. Malate increases your energy and acts much like caloric restriction on your NAD.

That said, I strongly vouch for Tru Niagen from ChromaDex as the best Nicotinamide Riboside supplement. It’s the best NAD supplement out there, with proven effects, and a Nobel laureate in Chemistry helps manufacture it.

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