The scientific world has been abuzz recently due to the potential world-changing research on NAD+.
In a now-famous study a few years ago, scientists found that they could reverse aging in mice using NAD+.
This study shows two-year-old mice (which is old for mice), become indistinguishable from a few months old mice.
They achieved this by increasing a crucial cellular compound called Nicotinamide Adenine Dinucleotide (NAD+).
As a result of these groundbreaking studies on increasing Nicotinamide Adenine Dinucleotide, several new products come spring into the market containing the NAD+ precursor nicotinamide riboside (NR).
Aside from its anti-aging effects, these supplements have shown other potential benefits.
Several studies, as well as many customers, have reported a wide range of benefits: a reported boost in energy levels, improved cognition, enhanced sleep activity, as well as many other benefits.
We wanted to know if this was all hype or a truly groundbreaking vitamin supplement. So we decided to look into it.
If you, like many others, have been looking into NAD+ then you may have heard of Tru Niagen.
They have a good reputation and are pioneers in the field.
Their patented nicotinamide riboside compound has undergone rigorous clinical trials and testing, and the claims on the benefits sound almost too good to be true.
TRU Niagen Nicotinamide Riboside (NR) Advanced NAD Supplement Review
In the year 2004, Dr. Charles Brenner discovered nicotinamide riboside (NR) could potentially increase vital cellular resource levels. He is Chief Scientific Advisor for the Truniagen brand!
The Harvard Medical School study found that older mice had fewer NAD+ than younger mice.
They dramatically increased the mice’s NAD+ lvls through oral administration.
After the study concluded, it was found that the older mice looked and were genetically identical to much younger mice.
The lead scientist on the scientific study, David Sinclair says: “We can’t tell the difference between the tissues from an old mouse that is two years old versus a young mouse that is three to four months old.”
Although the same study hasn’t yet been performed on humans, there have been several human clinical trials on NAD+ that have reported a variety of health benefits.
In fact, more than 150 scientific articles have been published about NAD+ and NR compounds since 2004.
Each one is revealing more potential benefits of taking a product such as Tru Niagen.
Some of the benefits mentioned in these clinical studies are, of course, anti-aging. It may also improve mental clarity and prevent cognitive deterioration diseases like Alzheimer’s.
But further reviews and research into human trials are needed. It would seem that the research is pointing to NAD+ having a remarkable ability to keep cells young and extend their life.
NR and NAD+ may be the future of research into curing and reversing degenerative diseases.
What Are The Tru Niagen Ingredients
Tru Niagen contains a form of B3 that has been proven to raise NAD+ lvls safely in humans.
Their compound is made in facilities in the United States and undergoes rigorous testing.
The key ingredient is nicotinamide riboside chloride which is the precursor to NAD+ in our bodies.
The NR compound in Tru Niagen is a patented modified version of vitamin B3 that facilitates the natural production of NAD+.
NR is found in trace amounts in milk, avocados, and other vegetables.
But these trace amounts are not enough to encourage NAD+ production. Each Niagen capsule contains 150 mg of NR.
There are a few other ingredients in the capsules, but they are there to keep the NR working and fresh.
Tru Niagen capsules are guaranteed to be vegetarian, contain no animal by-products, and no artificial flavors or colors. The capsules are nut, gluten, and caffeine-free.
How to Take Tru Niagen
What is the best time to take Niagen?
The company recommends taking 300mg (two capsules) of Tru Niagen at the same time every day.
You can take with or without food in the morning or at night.
The company recommends taking two of their 150mg capsules a day.
Once in the morning and once in the evening, both times with food. Based on one study this may be too little.
More research is needed into the best dosage to take for optimal results in humans.
Your dosage may also depend on how you react to Niagen.
There have been a few mild reported side effects, most of the mitigated when ingested with food.
Because as we age our NAD+ lvls decrease it is possible that it would be more beneficial to take more if you are later in life.
Talk to your doctor if you want to try taking more than the recommended dose.
How Does It Work?
NAD levels in humans decline as we age and metabolic stress contributes to changes in our overall health & wellbeing. Tru Niagen is a safe and effective way to encourage your body to make its own NAD naturally and increase nad. NR is the main ingredient in Niagen.
When our bodies receive NR, they will be able to produce the NAD+. Your body needs NAD+ in its natural form to allow your cells’ mitochondria to make energy. As our bodies age, they make fewer NAD+ by taking a dose of NR twice a day (not a particularly high dose), we can stop the plummeting levels of NAD+ in our bodies.
NR is a direct path to the production of NAD+. This allows your body to save time and energy in the production of NAD+. The more NR in the human body, the more it can produce and use NAD+. This is why NR is considered by most researchers to be the most efficient booster of NAD+ around. Taking 300mg per day of Tru Niagen for eight weeks shown to raise NAD blood levels by 40 to50 percent.
What does NR Do and It’s Purpose?
NR, a protein-derived natural molecule, was used as a dietary supplement, but only with limited success. It acts on the mitochondrial level. Mitochondria is responsible for the oxidation of fats. NR is a protein-derived antioxidant.
It has been studied and found to:
- reduce lipid oxidation
- support mitochondrial function
- reduce the accumulation of oxidized lipids in tissues
The United States Food and Drug Administration (FDA) states that this NR has beneficial effects on inflammatory conditions such as muscle cramps, joint pain, and appetite stimulation. However, this compound’s active ingredients are unknown, so the FDA has not approved it for human use.
NR is a close relative of capsaicinoid compounds. Studies show that NR may be beneficial for disorders, including diabetes, pain, and autoimmune conditions. In addition to its antimicrobial properties, NR may have benefits.
What does it do?
Natural NR was first isolated from plants in Japan in 1938 and has been studied ever since. NR is a substance that is found in plants, animals, and water. Science shows that it belongs to a class of compounds called flavonoids. The majority of NR is found in plant or animal tissue, and blood levels are very low. NR also exists in urine and stool.
In vitro and in vivo animal studies have found that NR prevents aging and injury by restoring mitochondrial activity and reducing free radicals. A study in 2004 determined that NR, or other flavonoids, improves the regeneration of muscle tissue and promotes fat oxidation in rats’ muscle cells. The researchers concluded that flavonoids could have anti-inflammatory effects in animal models.
Is Tru Niagen FDA approved?
Tru Niagen is FDA registered and licensed to be sold for dietary supplementation only. Tru Niagen supplementation contains no preservatives. The active ingredient in Tru Niagen is D-Niacinamide (vitamin B3). The FDA does not approve D-Niacinamide for any medical use. It is also called nicotinamide.
Dietary supplements (FDA) are defined as food additives or food substances intended for use in food for people who cannot absorb or use other foods. Individuals with gastrointestinal disorders such as Crohn’s disease, celiac disease, irritable bowel syndrome (IBS), or inflammatory bowel disease (IBD) are sensitive to niacinamide and may not be able to tolerate it in any form.
Tru Niagen vs. Elysium Basis
The biggest competition for Tru Niagen is Elysium Basis. They use the same ingredient, which is a patented NR compound.
The two companies are currently in a law-suite with each other over the NR compound. The parent company of Tru Niagen, ChromaDex, is the owner of the patent.
For a few years, ChromaDex licensed the NR compound to Basis. In 2016 parent company Chromadex revoked the license.
TruNiagen is now the only legal seller of the NR compound. But Basis hasn’t stopped using the patented compound.
This is why Tru Niagen is suing Basis for its illegal use of its patent-protected product.
Another concerning matter is what Chromadex claims they found when testing bottles of Basis for their NR compound. Allegedly they found significant amounts of toluene.
Toluene is used in adhesives, nail polish, and other paints. If these claims are correct, they are worrying.
Tru Niagen Benefits for Weight loss & Energy
One reported benefit of taking Nicotinamide riboside is that it may help you lose weight.
In a study done on mice, it was reported to have helped speed up their metabolisms.
It’s still not clear whether or not this is true for humans as well; further studies are needed.
Many people who have been taking Niagen have reported that it has helped in weight loss.
Another remarkable potential benefit of taking Niagen’s NR compound is that it can increase energy levels.
When NR inside the cell gets to work, it can help form NAD and communicate with sirtuins, the cellular repair promoting proteins. These sirtuins then work to help cells stay young and strong as we age and provide cellular repair.
In multiple user reviews reported a significant energy level increase from taking it.
There have also been a few studies on potential energy increases.
One study found that boosting NAD levels can help treat jet lag by helping your internal clock reset faster. NAD is a fundamental resource for cellular energy production.
Another study found that because it may help and support healthy muscle aging, it could help you feel more energetic and younger longer.
Are There Any Side Effects?
Niagen’s ingredient compound has few reported side effects in even fewer people who take it.
In human trials, people taking 1,000 mg to 2,000 mg per day reportedly had no harmful effects.
There were a few people who complained about some mild side effects.
Some complained of nausea, indigestion, stomach discomfort, diarrhea as well as mild fatigue, and headaches.
People who take the recommended dose of 300 mg a day have said that they experience even fewer side effects
Are There Possible Benefits for Skin & Hair
A new study looking into NAD+ has shown it has some remarkable links to helping support and reverse the aging of hair and skin.
In the study on mice, it showed some real promise in reversing wrinkles, encouraging hair health and growth.
However, it is important to remember that because most of these studies have been done on mice, further research into human effectiveness is required.
Is NR The Same as Niacin?
Many people believe that Niagen is just niacin. While it true that it is a form of vitamin B3, it is not actually niacin. NR is a modified version of vitamin B3.
This compound is unlike niacin because it doesn’t cause any flush or itchiness in the skin.
The avoidance of the “niacin flush” is one of the benefits of taking this patented version of B3.
Niacin also does not have the same health benefits as NR in clinical studies and clinical trials.
By modifying the structure of vitamin B3, it aids in the production of NAD+ (To advocate Cellular Energy Production).
Although niacin has some amazing potentials on its own, by taking NR, you can get all those benefits and the healing potential of NAD+ production.
Does Tru Niagen Help With Sleep?
If you do decide to try the diet, make sure you read the associated study first. The research by Dimitra Chatziioannou and Arlene Shvartsman did not include anyone who was on a long-term diet or any other form of supplementation that might interfere with its effectiveness. This means that they can’t be sure that those who lost weight as a result of the diet also lost sleep. It’s important to remember that there are no good or bad foods, just what we know can have an impact on our health. The important thing is to pay attention to your personal biology when it comes to your nutrition and consider the science when making food choices.
If you’re thinking about a diet or some form of supplementation, you should always consult with your doctor to determine if it’s right for you. A healthy lifestyle is a lifestyle that we all can afford to stick to, regardless of the diet or supplement we choose. The only real scientific study into whether tau is really related to sleep can be found here. It concludes: “My perception is that tau induces insomnia but this is a mixed result. I don’t think it is anything particularly special in the nutraceuticals. If I had to choose I would be more likely to think it affects sleep and appetite than perhaps sleep cycle.
Prices & Where To Buy It
If you want to buy Tru Niagen supplements, we recommend buying directly from their official site. No coupons or discount codes are available, but they have the best price compared to a few of its competitors.
This will ensure you are getting the true NR compound at a reasonable price.
There are some people online who are selling knock-offs or heavily marked-up products.
Tru Niagen is also available on Amazon, but we found that it can have a slightly higher price tag.
Does Niagen Raise Blood Pressure?
Niagen may raise blood pressure if the dose is too large. One study showed that mice on a high dose of Niagen developed hypertension and suffered from enlarged arteries. However, this was not the case in humans who consumed 50 mg of Niagen daily, in comparison to the placebo, over the course of 14 weeks. The end result of the study found that the high-dose dosage caused no changes in blood pressure. This same study also showed that consumption of high doses of Niagen could reduce white blood cell count.
The researchers determined that there was a lower level of leukocyte (white blood cell) stimulation from Niagen and 5-acetylcysteine (5-ACE), and increased activation of the TLR-4 receptor. While these studies suggest that Niagen could reduce blood pressure, the researchers must be cautious about the subjectivity of their observations, and cannot explain why or how Niagen is involved in these cases. The authors of the study suggest that increased leukocyte count and TLR-4 activation are potential side-effects of Niagen, but they are.
Although it seems more clinical studies and human trials are needed, NAD+ is showing some remarkable potential and evidence into longevity.
The NR compound that Niagen offers has been clinically proven to increase levels of NAD+ in the body.
With its low tendency to cause side effects and testimonies praising its benefits raining in it’s hard not to think taking this vitamin supplement is a bad thing.
It’s hard to believe that a little vitamin supplement can help heal the mitochondria of our cells so well, but that seems to be what scientists are starting to think.
It is now commonly understood the NAD+ is the key to curing and treating many degenerative diseases and helping improve longevity in humans.
One of the safest and most natural ways of increasing NAD+ is to use the precursor to it, NR.
The most trusted producer of nicotinamide riboside is Niagen. They hold the patent for the well-tested and safe compound.
NIAGEN has twice been reviewed successfully nder FDA’s new dietary ingredient (“NDI”) program, and has also been successfully notified to the FDA as recognized generally as safe (“GRAS”).
It would seem that there is very little to lose from taking this vitamin supplement.
The potential benefits of muscle regeneration and cognitive health alone make it worth a trial run.
If you are interested in looking further into Tru Niagen, we recommend reading more about it in the published trials.
Perhaps you can talk to your doctor or healthcare informer about the findings on NR.
It may be a few more years until we know whether this is the wonder drug it seems to be.
But so far, the evidence seems to say it is.
I don’t know about you, but I am taking the plunge…
Disclaimer: These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure, or prevent any disease.