- If you are someone who curious about Nicotinamide Riboside (NAD precursor that is proven to increase NAD levels) and wondering which of the two available NAD supplements you should be taking. There are only 2 Legitimate Choices: It Is Tru Niagen from ChromaDex and Elysium’s Basis?
- Two companies are in a patent war with each other, but what you need to understand is that as of now Elysium used to get NR from ChromaDex, and now due to Elysium Health lawsuits they are getting it from unknown sources.
- It doesn’t mean it’s bad, but if you want the same patent substance used in Nicotinamide Riboside research studies, you will be better off with TRU Niagen (Up to 40% off Right Now). Considering it is also a slightly cheaper route to go.
- Subscribing into True Niagen seems to be the only viable option (cheaper and more reliable) based on this review (current data).
Let’s find out which is the best NAD supplement…
NAD+ Supplement Review / What is the Best Anti-Aging Supplement?
Now you know everything there is to know about NAD and its precursors. Let’s see if we can get you the best supplement:
#1 Tru Niagen Nicotinamide Riboside
Tru Niagen Nicotinamide Riboside is currently the best & most researched product. Let me explain why:
Tru Niagen Ingredients
Each capsule contains 150mg of nicotinamide riboside chloride, and you should take two capsules per serving.
As you know, Nicotinamide Riboside is the most effective NAD precursor, so it has the best chances of being transformed into NAD inside the body.
This supplement is vegetarian; it has no gluten, no nuts, no caffeine, and no artificial colors or flavors.
According to data from the FDA regarding nicotinamide riboside solubility, Niagen is soluble in water.
Other ingredients include microcrystalline cellulose (anti-caking agent, and fat substitute) and Hypromellose (thickening agent and binder).
Science Behind the Supplement
This supplement has a lot of science backing it up.
There are four different clinical trials published in peer-reviewed magazines which show that NIAGEN® is a safe, effective supplement.
These clinical trials are based on over a hundred preclinical studies at famous universities like Dartmouth Medical school or the University of Iowa.
The FDA is on board with NIAGEN® too, plus the GRAS certification is there.
ChromaDex, Tru Niagen’s company, has over 20 licensed patents for making and distributing this product.
Besides, there are over 140 research collaborations between this brand and Top US universities, which aim to improve this supplement to make it true youth supplement .
IS There Any Discount Available?
Currently, you have the chance to save up to 40% if you buy Tru Niagen. This TOP supplement can cost as little as $30, plus you have free shipping in the US.
#2 Elysium Basis Supplement
I’m not really on board with Elysium Basis, and I’ve explained most of my reasons above.
I’ll summarize them here so that you can compare this supplement with Niagen.
Elysium Basis Ingredients
There are two main ingredients in Elysium Basis: 250 mg NR and 50 mg pterostilbene.
Other ingredients include thickeners and anti-caking agents like Microcrystalline Cellulose, Hypromellose, Vegetable Magnesium Stearate, and Silica.
The 250 mg Nicotinamide Riboside are good for their anti-aging effects. But the 50 mg of pterostilbene still makes me want to avoid this product.
Although I took pterostilbene a few years back, before the studies started piling up against it, I wouldn’t recommend it today.
Elysium Health still states that pterostilbene protects you from cellular stress and can improve your metabolism because it activates sirtuins.
Pterostilbene has a similar chemical structure as Resveratrol, plus Resveratrol and coenzyme Q10 have proven beneficial effects against normal aging.
However, pterostilbene also increases bad cholesterol levels. So if you already have cholesterol issues, I wouldn’t recommend this supplement. Otherwise, you could probably take it after talking to your GP about it.
Science Behind the Supplement?
This supplement features many studies on its official website to emphasize that it works.
A few of them aim to show that pterostilbene is a safe ingredient.
However, these studies have few participants and are short-term.
Other studies show the beneficial effects of normal NAD levels, like better mitochondrial and stem cell functions, along with reduced anti-aging effects.
The downside is that most of these studies are on mice.
Bottom line: the science behind this supplement shows that NAD is beneficial and that NR works, but didn’t convince me about pterostilbene.
Is There Any Discount Available?
Various discounts are depending on your purchase plan. One year prepaid deliveries allow you to save 33%, six months prepaid save you 25%, and a paid monthly delivery saves you 17%.
#3 Life Extension NAD+ Cell Regenerator Nicotinamide Riboside
This is another supplement that many people are referring to, but it is not even worth mentioning. It’s just 100mg dose and cost can go higher compared to other 2 supplements considering the same dosage.
Elysium Health Include Pterostilbene, Should You Subscribe to It?
Pterostilbene is a compound that makes your body think you’re on a calorie-restricting diet.
As we’ll discuss later, caloric restriction and NDA go hand in hand.
If you take a supplement with pterostilbene, you’ll lose weight faster and accelerate the effect of NDA.
Elysium Health was on board with this levels of NAD+ research from the start, so originally they were the only brand that mixed NR and pterostilbene.
However, a recent study showed that pterostilbene increases your bad cholesterol levels.
ChromaDex has also stopped commercializing pterostilbene after it’s been shown to increase LDL.
Taking that into account, I wouldn’t recommend any supplement which uses this substance.
Besides, Elysium has had various other problematic ingredients, like trace residue of toluene.
While this isn’t the most toxic artificial ingredient, it’s still a problem that Elysium didn’t disclose it’s manufacturing process to the FDA.
Nicotinamide Riboside Research! Do NAD-Boosting Supplements Have Anti-Aging Effects?
Low NAD lvls in the body are known to impair our mitochondrial function.
With age, our NAD lvls decline, so does the mitochondrial functionality.
Scientists suggest that increasing NAD lvls may delay aging and all the bad diseases that come with it.
What I’m interested in discovering if it is really true and if NAD really may help to delay aging and make us more energetic right away. Is there any product that can help? Possibly!
Public interest in NAD has grown in the last few years as research started to pile up looking at the role of mitochondria decline that you can find in numerous age-related conditions and diseases, including Alzheimer’s, diabetes, cancer.
Researchers are reviewing enzymes that are dependent on NAD, particularly sirtuins that seem to be vital in aging.
Nicotinamide riboside (NR) is a form of vitamin B3 (niacin) that is a NAD precursor. It boosts NAD levels and increases mitochondrial function. Some small amounts of NR can be found in some foods, that contain whey or yeast.
Researchers into NAD precursors got a surprise when a study by famous scientists, printed in the Cell journal, discovered that injections of different precursorsrejuvenated mitochondria in old mice.
NR is marketed as a supplement called Niagen by a company that has licensed patents from the universities that discovered how to synthesize.
Also, a Nobel Prize winner in Chemistry is on the company’s advisory board.
The existing research shows some convincing results on animal trials.
These supplements are known to increase NAD (nicotinamide adenine dinucleotide) levels in test animals.
Afterward, NAD helps the mitochondria release more energy.
In turn, more energy leads to enhanced DNA repairs and your body working better.
NAD lvls decrease with biological age, so that’s why NAD supplements are becoming more popular.
NAD and sirtuins appear after prolonged calorie-restrictive diets, and they’re also linked to Resveratrol.
This molecule is found in the skin of dark grapes and has a potential beneficial effect against aging.
That’s why Niagen can sell NR as well as other supplements.
The brand organized a small 6-week trial study you can find in Nature Communications.
The results show that NR can increase the NAD lvls in the bloodstreams of healthy older adults.
The catch is that the doses taken by the subjects were double the ones indicated on the label.
While this doesn’t show causation between increased NAD lvls and anti-aging, the company awaits FDA approval for its product, which they think can treat Cockayne syndrome.
This genetic disease is rare and determines children to age prematurely.
What Are the Benefits of NAD?
To answer this question, imagine all the risks of decreased NAD levels in the blood.
One consequence is neurodegeneration. Conversely, increased NAD levels can make you more alert, improve your memory and mental clarity.
Decreased NAD levels are also linked to vascular inflammation, increased fat storage in your liver and your adipose tissue, insulin resistance, fatigue and decreased muscle strength.
In turn, normal NAD lvls improve the health of your blood vessels, so you’re at less risk for heart issues.
NAD decreases the dangerous production of fat cells so that you can avoid illnesses such as nonalcoholic fatty liver disease.
With a normal production and deposition of fat, you can also avoid the risks of extra belly fat.
Normal NAD lvls allow your body to consume the extra blood glucose, so you have steady blood sugar levels.
With NAD activating your energy production in the mitochondria, your body will burn more fatty acid, giving muscles an excellent source of energy.
Instead of feeling fatigued, you’ll feel rested and strong.
NAD helps you fight the usual health problems associated with old age so that you can feel, think and act better.
Other NAD Precursors?
There are four NAD precursors you may have heard of:
Is Nicotinamide Riboside Safe?
The short answer: yes. The longer answer is eponymous to the name of this article here: Chronic nicotinamide riboside supplementation is well-tolerated and elevates NAD+ in healthy middle-aged and older adults.
This study above is extremely clear to the benefits and safety of taking NR, but there is other research that shows the same thing.
NR can actively increase NAD levels; it improves brain health, makes you livelier, and gives you more energy.
It works for older people; it’s effective and well-tolerated.
Pro tip: The best time to take NAD supplements is in the morning, on an empty stomach.
Nicotinamide Riboside Side Effects
Some people have reported mild to moderate side effects, such as fatigue, nausea, diarrhea, headaches, diarrhea, stomach discomfort and indigestion.
The dosage of 1000mg of NAD+ supplement to 2000mg daily for humans has no dangerous effects. Animal test trials show no harmful effects either.
The only issue is that these human studies are short-term and involve few subjects.
There are no warnings against the use of nicotinamide riboside supplements.
I would like to see more extensive tests with plenty of participants observed throughout a few months or longer.
That said, the current studies show that NR can cause a bit of nausea, headaches, stomach discomfort, and tiredness.
Besides, NR doesn’t cause facial flushing like niacin.
How Can I Increase My NAD Naturally?
Sulforaphane is an antioxidant that helps protect our cells from cellular damage and boosts our antioxidant defenses. There are many different ways to boost our NAD levels naturally. Here are some tips to get you started: It’s just a matter of finding out which ones are the best for boosting your NAD lvls. Elevate your Sulforaphane intake: As mentioned earlier, it’s possible to boost your Sulforaphane levels by eating celery, dandelions, parsley, and leeks.
As mentioned earlier, it’s possible to boost your Sulforaphane levels by eating celery, dandelions, parsley, and leeks. Supplement with Sulforaphane: Sulforaphane is also available as a supplement, but is currently not approved for use in the UK. It is available in the US, but you can read more about it in our expert view on low-dose Vitamin D3. There are a few natural ways that can help increase NAD+ supplements, boosters precursors naturally but it is really very little compared to the number of nutrients that can be taken to increase this nutrient in the body. The best way to improve your NAD lvls is by using the ketogenic diet. It is full of high-quality fat which will help you burn fat faster. You can also eat certain foods that have the ability to strengthen your vitamin D and B-12 levels, which will help you build your NAD naturally.
Can NAD Reverse Aging?
Aging raises the level of the metabolism-suppressing molecule NAD in our blood. A daily supplement of NAD or NAD+ reduces the signs of aging. In 2006, Dr. Dongsheng Cai and his colleagues from the University of Texas investigated the molecular pathways in the cells of the fruit fly, Drosophila, that are affected by the increase of NAD+ levels. They observed that a gene called Bcl-2 was expressed more strongly in old flies. This gene is a key factor for the survival of aging cells in our body. When they increased NAD+ levels in old and young flies, they found that the expression of Bcl-2 decreased, suggesting that this protein is important for the survival of cells.
Moreover, they investigated which biological factors also affect the expression of Bcl-2. They found that an amino acid called methionine plays a crucial role in regulating the expression of the Bcl-2 gene. In a similar manner, scientists from the Korea Research Institute of Bioscience and Biotechnology (KRIB) observed that the reduction of NAD+ levels impairs the biosynthesis of the coenzyme Mp-1, which is also essential for the survival of cells in our body. In such a way, we should not ignore the quality control of our bodies. NAD+ level must be monitored to keep our body in shape and to stay healthy.
Does Niacin Increase NAD?
Yes, but only in your liver and it is not known how much is getting into a cell.
Therefore, niacin supplements – or vitamin B3 – can help reduce bad cholesterol levels.
Niacin doesn’t have other anti-aging results, like improved memory function, more cellular energy, less muscle fatigue, or improved cardiovascular health.
Which is Better Resveratrol or Pterostilbene?
Pterostilbene, which is what anyone can purchase from Vitamin World or any drug store, has many important biological activities, including protection of DNA, wound healing, and limiting inflammation. It also reduces blood pressure and seems to block the high levels of hormones that have been linked to heart disease, diabetes, and cancer. Resveratrol on the other hand is a natural compound in red wine, and grapes in general, that has been extensively studied for its health-promoting properties. And it does have powerful anti-aging and cancer-fighting effects. Researchers in Japan also have found that resveratrol, when consumed in combination with the body’s own antioxidant supply, can greatly slow the aging process and even reverse the signs of aging. Some of the more well-studied effects of resveratrol are helping prevent cancer.
Which is Better Nmn or NAD?
Though nothing is going to replace the health benefits of a regular detox diet, if your body is getting lazy you can rest assured that it will eventually take action and start putting the carbs back into the system. For most people, although their bodies want a higher level of carbs, they don’t actually crave it. It is actually their body’s natural process to put the excess fuel right back into the body.
So the way to reverse it is to simply remove the extra fuel from your system and see the result! This is actually pretty easy to do, and you only need to do this once or twice a year to see the results. For maximum results, I like to drink 2 liters of detox water per day. Each day, I will drink 1 liter of water, then one of alkaline water.
How to Increase NAD Levels Naturally
If you don’t think there’s such a thing as a miracle pill, here are some ways to increase NAD+ levels:
You can start a ketogenic diet, which is high in fat and low in carbs, to improve your energy metabolism.
When your body burns fat instead of glucose to get energy, you’re in ketosis.
In ketosis, your NAD+ levels increase, so your body can fight free radicals and slow down the effects of aging.
Intermittent fasting increases NAD+ because you’re restricting your caloric intake, which leads to increased sirtuin production.
Intermittent fasting is a cell regenerator and boosts your metabolism, unlike traditional calorie-restrictive diets.
Oxaloacetate is another way of increasing your NAD levels because it transforms into malate in your body. Malate increases your energy and acts much like a caloric restriction on your NAD.
That said, I strongly vouch for Tru Niagen from ChromaDex as the best Nicotinamide Riboside supplement. It’s the best NAD supplement out there, with proven effects, and a Nobel laureate in Chemistry helps manufacture it.
Conclusion. Do NAD+ Supplements Really Work?
NAD+ is a vital coenzyme involved in various cellular processes, including energy metabolism and DNA repair. While NAD+ levels naturally decline with age, leading to potential implications for overall health, the question of whether NAD+ supplements truly work is a complex one.
Scientific studies have demonstrated that NAD+ precursors, such as nicotinamide riboside (NR) and nicotinamide mononucleotide (NMN), can effectively raise NAD+ levels in various tissues. This indicates that NAD+ supplementation has the potential to restore cellular NAD+ levels. However, the clinical benefits and long-term effects of NAD+ supplementation in humans are still being actively researched.
While some preclinical and early-stage human studies suggest potential benefits of NAD+ supplementation, such as improved mitochondrial function and potential anti-aging effects, further rigorous clinical trials are needed to establish its efficacy and safety conclusively. It is important to note that individual responses to NAD+ supplements may vary, and the optimal dosage and duration of supplementation are still areas of ongoing investigation.
Therefore, while the scientific evidence indicates promising potential, it is advisable to approach NAD+ supplements with caution and consult with a healthcare professional for personalized advice. They can help assess the suitability of NAD+ supplementation for specific health goals and provide guidance based on the most up-to-date scientific research. Can you buy NAD over the counter? NAD+ (nicotinamide adenine dinucleotide) supplements are available for purchase over the counter in many countries. NAD+ precursors, such as nicotinamide riboside (NR) and nicotinamide mononucleotide (NMN), are commonly sold as dietary supplements. However, it is important to note that regulations regarding the sale and marketing of dietary supplements vary across jurisdictions. It is advisable to check the specific regulations and requirements of your country or region regarding the availability and purchase of NAD+ supplements. Additionally, consulting with a healthcare professional can provide personalized guidance and help determine if NAD+ supplementation is appropriate for your specific health needs.