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7 Best Ampk Activators (2023) | Metabolism-Bosting Supplement

AMPK has documented health properties, but there are over fourteen thousand articles and almost fifteen thousand user reviews on AMPK Activators.

I’ve read most of these reviews and articles. I can’t compromise when I make professional recommendations to clients daily. Now, you have access to all that research on today’s best supplements.

Life Extension AMPK Activator is the best overall in today’s market because it’s based on numerous clinical trials.

Life Extensions is medically proven to improve your health. However, there are other worthwhile supplements that address specific purposes.

Read the article below to find the best AMPK activator for your needs. You will learn how these supplements work and how to use them. You will find all their benefits and side effects and discover real consumer results.

Review Summary:

  • 1. Life Extension#1 Strongest Ampk Activator
  • 2. Takenutritionx
  • 3. Luz
  • 4. LA-3
  • 5. Berberine HCL
  • 6. Dr. Kardashi Premium Berberine
  • 7. Berberine 1200mg HCL Plus Ceylon Cinnamon Capsules

What is an AMPK Activator?

They are compounds that activate AMPK, and AMPK is short from adenosine monophosphate-activated protein kinase.

This enzyme is essential in stabilizing energy homeostasis, so your metabolism works well.

Niacin AMPK helps burn the calories you need according to the energy demand.

What is AMPK

People with metabolic issues or cancer sometimes burn too many or too few calories.

AMPK is a therapeutic target that helps keep chronic metabolic illness or even cancer in check. Ampalive supplement reviews show these results.

AMPK can be obtained from food or quality supplements available on reputable websites like Amazon. You’ll find how to get these options below.

SUMMARY: AMPK Activators trigger the production of AMPK enzymes, which heighten your metabolism. Use those supplementation to ensure your cells are in their best health.

7 Best Ampk Activator Reviews (List for 2023)

The supplements below are strong and thoroughly tested. They kickstart your metabolism and address a wide range of issues.

As each person has different needs and medical difficulties, I’ve selected the best supplements for each purpose. I’m sure reading below will help you find the right AMPK supplementation.

1. Life Extension – #1 Best AMPK Metabolic Activator

Life Extension AMPK Metabolic Activator

Life Extension AMPK Metabolic Activator is the best choice because you can trust it works. It has the most positive reviews, it’s made by a reputable company, and it is backed by a lot of research.

Each bottle contains 30 easy-to-swallow pills, which:

  • Are made with quality ingredients. The mix of Calcium carbonate, Hesperidin, and Actiponin gynostemma extract is a reliable AMPK activator. Your aging cells will receive new life to better remove old cells, fight infections, and produce more energy. This supplementation is clean, vegetarian, and contains no GMOs. However, you may dislike the addition of thickening agents.
  • Help burn fat. The product makes a false claim of burning belly fat, but that is scientifically impossible. Life Extension AMPK helps you burn fat from all over the body. Once your cells’ metabolism is working faster, they will burn more energy. Besides, calcium is known to accelerate fat loss.
  • Improve your immune system. As your cells’ metabolism is hastened, they’re able to fight inflammation better, to replicate faster, and to eradicate sick cells. The result is you’ll lower your risk of chronic illness or infection.
  • Easy-to-swallow capsules
  • No GMOs
  • Fat loss
  • Rejuvenation of your cells
  • Illness prevention thanks to increased AMPK levels
  • Trustworthy (proven to work in many clinical trials)
  • Doesn’t target belly fat specifically as advertised

Summary: Life Extension AMPK Metabolic Activator is a quality mix of balanced ingredients that improve your cellular metabolism. Get this supplement and your body will be able to fight illness and burn fat.


2. TakenutritionxTakenutritionx AMPK Activator Boost

Takenutritionx AMPK Activator Boost has many happy Amazon customers. Chances are you’ll see the same progress with your fat loss and testosterone levels as they did.

Most people agree that taking this supplementation increases your stamina. The probability of it working for you is at least 70%, considering the product has a 3.5-star rating on Amazon.

The brand also claims its supplementation produces and breaks down sugars, which helps you prevent and manage symptoms of diabetes.

As TakeNutritionx Boost hastens cell metabolism, it also stabilizes your blood circulation and improves cardiovascular health.

  • Gynostemma Pentaphyiium Leaf Extract (450 mg) is clinically proven to boost your energy and strength. This ingredient works well in pre-workout supplements.
  • Quercetin Dihydrate (100 mg) effectively eases diabetes, gastric issues, inflammations, and tiredness. This enzyme is an antiviral, it can prevent cancer, and it also increases your athletic endurance.
  • Berberine HCL (100 mg) controls blood sugar levels, accelerates fat loss, and keeps your heart healthy.
  • Increased stamina thanks to berberine quercetin and gynostemma
  • Good for diabetes control
  • Energy booster
  • Reduces tiredness
  • It takes a few weeks to see weight loss results

Summary: Takenutritionx Boost’s mix of ingredients can increase your stamina and diminish fatigue. Although it’s not excellent for weight loss, get this if you need more energy.


3. Luz

Luz AMPK Activator

Luz AMPK Activator is great if you need a powerful, natural AMPK supplement to reinvigorate you. As your ketone levels increase, you can lose weight faster and keep your diabetes in check.

This product contains the complete dose of all the four supplements you need each day, with high concentration.

The clinical dosage ensures a bullet-like action for your problems.

  • Clean product. Luz contains vegan ingredients, free of gluten, GMOs, and pesticides. Other safe ingredients for you are cellulose and microcrystalline cellulose. These are used to envelop the capsule and for anti-caking.
  • Improves health. The mix of ingredients benefits your mental health, gives you increased energy, and lengthens your lifespan. All the ingredients have clinically-effective dosages for maximum results:
    • Gynostemma 80% on energy
    • Berberine 99% on heart health and diabetes
    • A-Lipoic Acid 99% on brain protection
    • Resveratrol 98% to reduce your age-related cognitive decline and your insulin sensitivity.
  • Clean ingredients, with no GMOs, allergens, or toxic substances, that are safe for you
  • Backed by quality research
  • The clinical dosage for all ingredients ensures maximum results
  • For health and longevity
  • Vegan
  • Increases your ketone levels
  • Not best for weight loss if you don’t change your diet
  • Mild GI distress the first couple of days

Summary: Luz AMPK Keto has clinically-effective ingredients to improve your health and increase your energy. Get this supplementation if you want to lose weight slowly but surely because it will increase your ketone levels.


4. LA-3 – Boost Energy and Promote Longevity

LA-3 AMPK Activator

LA-3 AMPK Activator has a 3.4-star rating on Amazon, so there’s about a 70% chance this supplement will also work for you. Just like most customers, you will feel more energetic, increase your libido, and notice glowing skin.

  • Increased energy and health. It has the same ingredients and concentrations as Takenutritionx Boost:
    • Gynostemma leaf extract for energy
    • Quercetin dihydrate to reduce inflammation and to increase your stamina
    • Berberine HCl 100 mg for cardiovascular health and lower blood sugar

So just like Takenutritionx Boost, LA-3 AMPK Activator is best for increased energy and sex-drive.

However, other ingredients include Rice Flour, Stearic Acid, and Hypromellose. These are not the best options.

Rice flour is packed with carbs, so it’s not a keto-friendly option. Stearic Acid might have a laxative effect and interferes with the absorption of the activators.

  • Good reviews prove it works for most people
  • Quality mix of AMPK for safety and good results
  • Increased energy
  • Increased libido
  • Not for keto dieters (added rice flour)
  • Possible laxative effects, especially as you have to take two capsules on an empty stomach
  • Lower absorption rate than other products

Summary: LA-3 AMPK Activator is not the #1 supplement for keto dieters. You will notice moderate weight loss effects if you restrict your calories. Get this supplementation if you need to improve energy and libido.


5. Berberine HCL


Berberine HCL 500mg by Double Woods is best for stabilizing your sugar levels and heart health. That’s thanks to a high dosage of 1,500 mg total of Berberine every day.

Berberine is an alkaloid used for millennia in Chinese medicine. Western medicine has also proved its significant effects on insulin-resistant people. This means the supplementation is an effective AMPK activator that will most likely work for you.

This supplementation is:

  • Increased metabolism. Berberine activates AMPK and stabilizes your blood sugar because it helps your body metabolize glucose faster. This product is good for people with PCOS, diabetes, high cholesterol, and those on keto.
  • Weight loss. Berberine stops the production of fat cells at molecular levels. The result is people on a dose of 1,500 mg of Berberine per day can lose a big chunk of their fat weight.
  • Lower cholesterol
  • Heightened metabolism
  • Stabilized blood sugar
  • Proven weight loss benefits

Summary: Berberine HCl is best if you have high blood sugar, cholesterol, or obesity. Berberine has shown to improve these conditions, so it will likely work for you.


6. Dr. Kardashi Premium Berberine

Dr Kardashi Premium Berberine

Dr. Kardashi Premium Berberine works if you have high blood sugar levels. However, it’s not as effective as Berberine HCL 500mg by Double Woods because:

  • You will get a lower daily dosage aka 1200mg instead of 1500mg
  • You’ll ingest more carbs because it uses rice flour as a thickening agent
  • You may not absorb it completely. This product uses Magnesium stearate which prevents the absorption of dietary supplements
  • GMO-free
  • GMP-certified
  • Stabilizes high blood sugar
  • Lowers cholesterol
  • Keeps weight in check
  • Not very effective if you are already obese or with full-blown diabetes

Summary: Dr. Kardashi’s Premium Berberine has quality ingredients, but moderate dosages. Get this product if you want to stabilize your weight gain and stop your pre-diabetes from evolving.


7. Berberine 1200mg HCL Plus Ceylon Cinnamon Capsules

Berberine 1200mg HCL Plus

Berberine 1200mg HCL Plus Ceylon Cinnamon Capsules has an excellent 4.7-star rating on Amazon, so there are 94% chances it will work for you.

Most people agree this supplement helped them control their blood sugar in a natural way, with no artificial ingredients. The probability is high to also get these results. You’ll appreciate the affordable price and high-quality berberine.

Each capsule has 450mg Berberine HCL and 150mg Ceylon Cinnamon. The daily dosage is a maximum of two capsules per day, which means:

  • You’ll get less Berberine than with the previous two supplements, so these pills are best for diabetes and obesity prevention, not treatment.
  • It’s effective. Ceylon Cinnamon increases absorption. This ingredient is also known to improve the health of your digestive system, immune system, heart, and metabolism.
  • Maximum potency
  • Third-party testing to ensure it works
  • Stabilized blood sugar
  • Increased absorption through the use of Ceylon Cinnamon instead of Magnesium Stearate
  • Anti-inflammation
  • Active PK FDA and GMP-certified facility
  • Vegan
  • Non-GMO
  • Not very powerful

Summary: Berberine 1200mg HCL Plus Ceylon Cinnamon Capsules is good if you have slightly high blood sugar or if you’re slightly overweight. If you don’t need immediate medical interventions, try this nature-inspired supplement first.


SUMMARY: The brands in this review address different purposes and needs. Some supplements are better for weight loss; others are best for energy and sex-drive. Some supplements can treat diabetes and high cholesterol, while others can simply prevent these problems. Keep your purpose in mind and consult your GP before choosing your AMPK-activator supplement.

AMPK Activator Ingredients

The supplements above include different ingredients. Choose the one that fixes your thing. Research the ingredients and dosages of all the supplements before deciding. It’s even better to discuss things with your GP.

Main Ingredients

Some of these ingredients include:

  • Calcium carbonate is best for your bone and heart protection, but it also helps your body burn fat stores.
  • Hesperidin has anti-inflammatory properties and improves your blood circulation.
  • Gynostemma Extract is a natural extract that increases your stamina and endurance.
  • Quercetin Dihydrate stabilizes your blood sugar and helps you fight fatigue.
  • Berberine HCL is best against your high sugar levels and high cholesterol.
  • A-Lipoic Acid protects your skin from aging, improves symptoms of diabetes, including neuropathy, improves your cardiovascular health, and reduces your obesity.
  • Resveratrol improves cellular metabolism and rejuvenates your cells. This compound keeps you healthier altogether, plus improves your mental health and clarity.

Pro tips:

  • If your goal is to lose weight, choose a supplement that includes Gynostemma Extract and Quercetin Dihydrate.
  • Choose a Berberine-based supplement if your sugar levels are high.
  • If you’re on keto, make sure your supplement doesn’t include extra sugar.
  • A supplement with clinical dosages can increase your ketone levels.

SUMMARY: Choose your AMPK supplement depending on your needs. Read the ingredient list and their dosages before deciding, and consult your GP.

How to Take. What Does AMPK Do?

Each of the supplements above has different recommendations on how to take them. Some supplements require up to three dosages, like Berberine HCL 500mg by Double Woods, while others require one dosage.

You might be required to take the supplementation on an empty stomach, or with your food.

  • Consult your GP and read the label carefully.
  • Don’t take more than the recommended daily dosage.
  • PharmacyIf you take the supplement correctly, the AMPK activator will do its job. AMPK is an important enzyme that regulates your energy balance, making sure you’re burning the right amount of energy and metabolizing all your calories.

Is Active PK a gimmick? Not at all. Here’s how it works:

  • AMPK is found throughout your body, from the brain to your muscles, liver, and fat cells.
  • AMPK enzyme contributes to the birth of ketones, aka ketogenesis. The result is that your body metabolizes sugar faster to reduce insulin sensitivity, and hastens your metabolism.
  • AMPK inhibits the synthesis of cholesterol, triglycerides, and lipogenesis. AMPK, therefore, reduces bad cholesterol and raises good cholesterol levels.

SUMMARY: AMPK increases your cell’s metabolism so they can do their job called homeostasis. Cells stay younger for longer, but they can also identify and fight attackers aka pathogens and their effects. AMPK regulates your hormones and makes sure sick cells are killed faster.

What Are the Side Effects of AMPK / Major Benefits From Taking

If you’ve read this far, you already know a bit about the benefits and side-effects of AMPK. Remember, though, that all these advantages and possible inconveniences depend on the ingredients and their dosage.

Not all AMPK activation supplements behave the same, but most have only mild side-effects.

From that point of view, they’re much better than Phenocal, which acts fast against obesity but causes severe vomiting and pain.

Benefits include:

  • Reduces your cholesterol
  • Increases your fat burning process to lose weight faster
  • Improves your stamina and energy
  • Increases your sex drive and testosterone levels
  • Stabilizes your blood sugar levels to avoid or reduce diabetes
  • Improves your circulation, which lowers your risk of cardiovascular issues
  • Decreases chances of diabetes and obesity
  • Helps you control your weight
  • Lower your risk of chronic illness like cancer or inflammation
  • Help to reduce the effects of aging (anti-aging properties)
  • Heightens your metabolism
  • Stabilizes your hormonal system

AMPK Supplement side-effects include:

  • You may notice slight GI distress depending on ingredients and dosage.
  • PPAR gamma and alpha proteins’ suppression in the long-term. These proteins are involved in stabilizing your blood sugar levels and liver health. They might also decrease your body’s ability to actively prevent atherosclerosis.
  • If you eat unhealthy fats and lots of sugar, absorption is repressed, so the supplements might not work as well.

Some supplements have more intense side effects, which require you to consult with your GP. For example, Sletrokor Diet Pills reviews show that not everyone can take this product safely.

SUMMARY: Most of them are marketed as fat-burning, weight-loss miracle pills. Although AMPK has many benefits for your general health, it can also trigger some GI side effects in the short-term.

What Foods Are High in AMPK? Activator Alternatives

If you want an AMPK activator alternative, consider eating more AMPK-rich foods, which are all-natural. Eating clean is always a good idea but might not be enough if you already have serious health issues or if you’re older.

Foods Are High in AMPK

Diet is a good prevention measure but can ease existing symptoms only in combination with doctor-prescribed medication.

That said, AMPK foods are:

  • Apple Cider Vinegar
  • Bark extract
  • Bilberries
  • Blueberries
  • Cinnamon
  • Extra-Virgin Olive Oil
  • Fish Oil
  • Ginseng
  • Grapeseed
  • Green Tea
  • Red Grapes
  • Soybeans
  • Turmeric
  • Vitamin E

SUMMARY: Good alternatives to AMPK Activator supplements include foods rich in antioxidants, healthy fats, and substances such as resveratrol. These foods have been used in homeopathic and Eastern medicine for millennia. However, quality supplements like the ones above have higher dosages. This means they’re more effective for curing rather than prevention.

Does AMPK Work for Weight Loss?

Some studies show that AMPK can assist in weight loss because it increases your metabolism. You’ll burn calories at a faster rate and burn more fat because it promotes ketogenesis.

For instance, Nucific Deep Cell Activator reviews show this is effective for your weight loss.

Burn Calories Faster

AMPK doesn’t help you lose weight unless you eat a balanced diet of healthy foods:

  • Trans fats and processed sugar prevents AMPK absorption
  • Stepping too much over your daily caloric limit means some of those calories will be stored as fat

Exercise activates AMPK even more. Use your extra energy and endurance to burn off those extra pounds, or you’ll become agitated and have sleep issues.

SUMMARY: AMPK heightens your metabolism and helps you lose weight, but it’s not a metabolic magical bullet pill against obesity if you don’t eat healthily.

How Can I Increase My AMPK Naturally?

Below is a simple method I use to increase my AMPK naturally, but remember that I’ve optimized it in several ways to maximize my results. I’ve given this AMP Diet a very simple structure – with a number of primal macros for every food group (though every food group would be eaten as well, such as eggs, grass-fed butter, and bacon). While I could’ve used a slightly more complex system, I wanted to make sure that I built my diet with a mix of food groups, like for the paleo diet. So this structure allowed me to pull from all the food groups and use it to my advantage, which is why I’ve left it simple in the blog post below.

As an overall exercise buff, I definitely understand how detrimental being sedentary can be for your health. AMPK allows you to get an extra dose of energy if you’re resting. Studies show that burning up to 60 percent of body fat in just one month with a meal plan that’s focused on proteins, veggies, and healthy fats (like avocados, olive oil, and nuts). Plus, the buzz it gives you from exercising is just the cherry on top. Eating Avocado. It contains a lot of health-promoting nutrients, like Vitamin C and potassium. Researchers have shown that avocados could work wonders to regulate blood glucose levels by improving your insulin sensitivity (yes, that is a thing). They’ve also found that the fat in the fruit could prevent fat build-up and lower cholesterol.

Does Fasting Activate AMPK?

A study published in Cell Metabolism in May 2017 used imaging to show that glucose and fat metabolism was dramatically improved after 18 days of intermittent fasting in mice. The authors concluded that fasting may activate AMPK, the process by which cells conserve energy as they undergo cellular metabolism. In a January 2018 interview, lead author Jason Block, Ph.D., described their initial observation that three of the five mice fed a high-fat diet lost weight and had increased insulin sensitivity, in contrast to their low-fat counterparts.

Block said that the single gene that was changed by the dietary change caused a subtle rise in AMPK, which lead to a reduction in the glucose level in the animals’ blood and less fat deposition. Block’s team published the mouse study along with several human studies in Science, one of which observed that in people who fasted for 12 hours a day for five days, cellular energy expenditure increased by 20% and decreased fat oxidation. Additionally, fasting for 12 hours a day decreased the mice’s cholesterol levels and altered a signaling pathway involved in fat metabolism, a process known as adipogenesis.

When to Take AMPK Metabolic Activator?

If you are not taking an AMP receptor supplement, you should start. AMP or Amminocyclitol is a metabolic product produced by the body that allows you to increase your performance and stamina. It will increase your energy level and give you an extra boost of energy when you are working out. AMP is an excellent anti-aging health supplement. People who are 65 years and older will develop a distinct set of lifestyle diseases that decrease the quality of their lives. To slow the aging process, they must take AMP. It is well known for being an excellent muscle-building supplement.

When is it best to take AMP? The best time to take an AMP product is after a workout. By taking an AMP supplement, your body can produce more AMP so that you can sustain your fitness level and increase your stamina. AMP acts as an energy booster. It contains powerful nutrients that are vital to your physique.

Frequently Asked Questions

Does Ampk Activator Really Work?

Scientific studies have shown that AMPK activators can stimulate AMPK activity in cells with promising results. Activation of AMPK has been found to improve insulin sensitivity, promote mitochondrial function, enhance energy production, and reduce inflammation. Several natural compounds, including resveratrol, green tea catechins, and curcumin, have been found to activate AMPK. Their effectiveness has been studied in both preclinical and clinical settings. AICAR and other synthetic AMPK activators have been studied in research settings. Though more research is needed to understand their full therapeutic potential, existing evidence supports their ability to activate AMPK and suggests potential benefits for various health conditions.

Does AMPK Reduce Belly Fat?

AMPK activation has been associated with potential benefits for reducing belly fat, although the effects may be influenced by various factors. AMPK plays a critical role in regulating energy balance and metabolism, including the breakdown of fats. When activated, AMPK stimulates fatty acid oxidation and inhibits lipid synthesis, which can contribute to the reduction of belly fat. Additionally, AMPK activation may improve insulin sensitivity, which can indirectly impact fat storage and metabolism. Studies have shown that certain AMPK activators, both natural and synthetic, can promote weight loss and reduce abdominal fat in animal models and limited human studies. However, it’s important to note that weight loss and fat reduction are multifactorial processes influenced by diet, exercise, genetics, and overall lifestyle. AMPK activation alone is unlikely to cause significant belly fat reduction without incorporating a comprehensive approach to weight management. Consulting with a healthcare professional can provide personalized guidance on how to achieve healthy and sustainable fat loss.

Consumer (Customer) Reviews & Results

Amazon and other forums are filled with divergent customer reviews and results with various supplements.

These people have tested at least one AMPK supplement before writing their opinion. Unsurprisingly, some say AMPK Activators work, while others say they don’t.

AnnaDisgruntled customers claim they see no effects, but you don’t know their diet plans or the severity of health issues. Some LCR Active PK reviews from people like Mary A. Cleaves and Anna show you also have to diet and exercise.

Customer reviews show that:

  • The supplements reviewed here have 3.5-4.5 star ratings.
  • Most people who’ve reviewed these supplements negatively either:
  • Some supplements are indeed low-quality because:
    • They don’t have the necessary dosages to work.
    • They contain ingredients that mess with its absorption.

That’s not the case with my list of products. Read a Sletrokor diet pills review to see how much people disagree.

  • Some supplements like LCR Health Active PK don’t have enough reviews on Amazon to decide if it works or not.

SUMMARY: Consumer reports and user reviews are often contradictory to supplements. If you want a good supplement, ensure it has at least a 3-star rating on Amazon. Ensure the people who speak badly of the supplement have taken correct dosages and purchased the right supplement for their needs. Users do not have the same results all the time because of different body structures, so get a proven supplement like Life Extension.

Final Words. Which AMPK Activator to Choose?

Choose the AMPK Activator that fits your profile and needs; otherwise, chances are it won’t work. Each of the products in this review is best for a certain purpose, and all of them have good ratings.

  • Takenutritionx Boost’s mix of ingredients can increase your stamina and diminish fatigue, but it’s not excellent for weight loss. South Beach Sciences Ampalive reviews show this supplement is better for losing pounds.
  • Luz AMPK Keto has clinically-effective ingredients to improve your health and increase your energy. As the ingredients stabilize blood sugar and increase ketone levels, this product can help you lose weight slowly.
  • LA-3 has moderate effects on energy and libido.
  • Berberine HCl is best for people with high blood sugar, cholesterol, or obesity
  • Dr. Kardashi Premium Berberine prevents you from gaining weight and is good for people with pre-diabetes.
  • Berberine 1200mg HCL Plus Ceylon Cinnamon Capsules is good for people with slightly high blood sugar or slightly overweight, who don’t need immediate medical interventions and want to try a nature-inspired supplement first.


Life Extension AMPK Metabolic Activator is the best choice because it has the most positive reviews, it’s made by a reputable company, and it is backed by a lot of research.


Choose this supplement because it can alleviate a multitude of your symptoms, such as tiredness, neuropathy, and weight gain.

Take advantage of its properties and order it now!