Home » Longevity » Supplements » Fisetin » Best Fisetin Supplement

Best Fisetin Supplement: For Focus and Support Autophagy

Fisetin, a powerful flavonoid found in fruits such as strawberries, apples, and persimmons as well as certain vegetables – closely resembling other phytochemicals like quercetin and kaempferol – offers antioxidant protection. Research has shown that it boasts multiple potential health benefits with its most significant being the enhancement of cognitive performance and memory while protecting against age-related deterioration in the brain.

fisetinFisetin has been clinically demonstrated to possess potent anti-inflammatory and antioxidant properties, in turn protecting cells from damage due to free radicals. It is additionally renowned for improving overall brain wellness, including cognitive performance and memory retention – a result of its ability to penetrate the blood-brain barrier enabling direct access into the brain.

Fisetin has demonstrated ample potential to protect against various diseases, including cancer and diabetes. Furthermore, it boasts anti-inflammatory benefits that have been observed to aid in reducing the severity of osteoarthritis symptoms and other conditions alike.

Considering its vast range of therapeutic applications, Fisetin has become a highly studied topic in recent years.

It is important to remember that more research needs to be done on Fisetin, including its effects, the best amounts and forms of supplementation, and how it interacts with other nutrients or drugs. Such knowledge will surely help optimize Fisetin’s potential benefits.

What are the Benefits of Taking? Why Should You Use A Fisetin Supplement?

Here are some of the marvelous benefits that Fisetin can bring to your physical and mental well-being:

  • Fisetin is packed with powerful antioxidants, which can protect our cells from being damaged by harmful free radicals. This could potentially help us to avoid chronic illnesses brought on by oxidative stress.
  • BenefitsFisetin has been proven to have a powerful anti-inflammatory effect and can aid in decreasing the risk of developing major illnesses like diabetes and heart disease. It works by reducing inflammation throughout the body, allowing for improved overall health.
  • Fisetin has been proven to bring about several cognitive advantages and improve memory recall, potentially improving overall brain function. Moreover, it may play a role in reducing the typical decline of aging brains as well. Quenching oxidative stress molecule.
  • Fisetin has the potential to drastically lower your risk of getting certain types of cancer, and it could even alleviate symptoms associated with osteoarthritis as well as other inflammation-related conditions.
  • In addition, Fisetin has been proven to have a beneficial influence on insulin sensitivity and glucose metabolism; this could potentially reduce the possibility of type 2 diabetes.
  • Moreover, research has revealed that Fisetin is also beneficial in promoting healthy blood pressure levels and cardiovascular health.

As Fisetin has been studied and associated with numerous potential health advantages, more research is necessary to understand its effects, the most beneficial dosage amount, methods of supplementation, and how it interacts with other nutrients or medications. It’s vital we keep in mind that while we know much about Fisetin already, there are still unanswered questions that require further study.

What Are the Side Effects of Fisetin?

Fisetin is a safe and natural dietary supplement, with no reported side effects when taken in recommended doses. Not only has it been proven to be non-toxic at normal levels of consumption, but its benefits are plentiful!

While supplements can provide many benefits, they may also lead to certain side effects or interact with medications. Some of the most common experiences that have been reported include:

  • Abdominal uneasiness such as queasiness, indigestion, and bowel irregularity.
  • Allergic reactions like skin rashes, hives, and even difficulty in breathing can all be caused by certain substances.

Moreover, it is essential to remember that Fisetin supplements do not undergo FDA regulation, so the quality and sincerity may differ from one brand to another. Hence, you should be sure to source a respectable company with certifications like GMP (Good Manufacturing Practices). With this certification in place, rest assured knowing that these supplements are consistently made under controlled environments.

Prior to beginning any fresh supplement routine, especially if you have an existing medical issue, or allergies or are taking medication, it is always essential to speak with a healthcare specialist. This will confirm that Fisetin won’t interact negatively with other medications and supplements you may be used as well as guarantee its safe use for your particular situation.

The Best Forms of Fisetin Supplement

A comparison of different forms of Fisetin supplements:

Form of supplementProsCons
TabletsConvenient to take, easy to swallowMay take longer to be absorbed by the body, and may contain binders or fillers
CapsulesEasy to swallow, can be taken with or without foodMay take longer to be absorbed by the body
PowdersCan be mixed with liquids or food, is fast-acting, and easy to adjust the dosageMay not be as convenient to take as tablets or capsules, can be messy to prepare
  • Fisetin tablets are one of the most popular forms of supplementation, as they offer convenience and effortless ingestion.
  • Capsules are a simple way to consume medication, and they can be taken with or without food. However, they might take longer time for the body to absorb them completely.
  • Powders are a convenient and fast-acting way to adjust your dosage, yet they may require more effort than tablets or capsules. Additionally, preparing the powder can be quite messy.

What is the Best Way to Take Fisetin?

In order to optimize the benefits of fisetin consumption, guidelines should be observed depending on your particular desired health outcome or condition.

Based on recent studies and research findings, these are some general rules for taking fisetin:

  • Fisetin dosage will depend on the product and condition being treated. Nevertheless, a study done in 2010 suggested that taking 30-50 mg of fisetin daily can reduce inflammation and protect neurons from damage among lab animals. In 2017, the journal “Oncotarget” released a study confirming that consuming 80mg/kg of fisetin on a daily basis can impede cancer cell growth.
  • Timing: As the research is inconclusive as to when the most suitable time for taking fisetin would be, intake with a meal is usually recommended. This will aid absorption while at the same time reducing any potential abdomen discomfort.
  • From pills and capsules to tablets and powders, Fisetin is readily available in a variety of forms. It can even be found in nature with sources like strawberries, apples, and persimmon!
  • Interactions: To be on the safe side, make sure to discuss with your healthcare provider before taking fisetin as it may affect certain medications.
  • Given the scarcity of safety data, pregnant and breastfeeding women should abstain from taking fisetin.

It is essential to remember that these recommendations are based on current studies and should not be regarded as medical advice. Prior to taking fisetin, it’s best to consult a healthcare professional for the appropriate dosage and timing tailored to your specific needs.

Best Fisetin Supplements Review

When selecting the right Fisetin supplement, it can be overwhelming to look through all of the available options. However, with a bit of research and knowledge on what makes an ideal product, you’ll find that choosing one is easier than ever! For starters, invest in a reputable brand; stick to only those supplements containing the appropriate dosage without any unnecessary fillers or binders for maximum efficacy; and lastly prioritize affordability. With these criteria met – you’ve found your perfect Fisetin supplement!

#1 Fisetin Double Wood – Best Choice

Double Wood

The Fisetin Double Wood supplement, brought to you by the esteemed and reliable company Double Wood Supplements, is a dietary pill that contains Fisetin as its prime ingredient.

In light of this fantastic product, here are both some upsides and downsides worth considering:

Made by a reputable companyMay be more expensive than other Fisetin supplements
Contains a high dose of FisetinNo information was provided on the purity or bioavailability of the supplement
Non-GMO, gluten-free, and third-party testedLimited information available on the effectiveness of the supplement
  • Double Wood Supplements, a trustworthy company renowned for their manufacturing of esteemed dietary supplements, created Fisetin Double Wood supplement.
  • This supplement is fortified with Fisetin, a powerful ingredient that may provide remarkable benefits.
  • The Fisetin Double Wood supplement is guaranteed to be non-GMO, and gluten-free and has been verified by third parties for its purity and quality assurance. You can rest assured that this product contains no harmful ingredients!

It’s critical to be aware that the productivity of this supplement is not validated since there isn’t much data accessible about it, but it has been manufactured by a reliable organization and is considered safe when consumed in accordance with directions. Nonetheless, prior to consuming any new supplement, be sure to speak with your healthcare practitioner as you may have existing health conditions or are taking medications that could interact negatively.

#2 Renue by Science LIPO Fisetin – Powdered Liposomal Fisetin



Renue LIPO Fisetin is a powerful dietary supplement, consisting of 150 mg of fisetin safely tucked in a liposomal capsule. Liposomes are specific fat molecules that secure and protect active ingredients like fisetin from the formidable digestive system to ensure it reaches our bloodstream with maximum efficiency-enhancing its bioavailability. This vegan-friendly formula offers 90 doses per bottle for your convenience.

Here are the pros and cons of the Renue LIPO Fisetin supplement:

Made by a reputable companyIt may be more expensive than other Fisetin supplements
contains Liposomal encapsulation for better absorptionNo information was provided on the purity or bioavailability of the supplement
Non-GMO, Gluten-free, and vegetarianLimited information available on the effectiveness of the supplement

Although there is limited information about the effectiveness of this supplement, it has been produced by a reliable company and is deemed secure when taken in recommended amounts. That said, remember to always consult with your doctor or healthcare provider before taking any new supplements – particularly if you have pre-existing health issues or are currently on medication.

#3 Life Extension Bio – Fisetin

Bio Fisetin

Life Extension Bio-Fisetin is a highly economical yet incredibly effective supplement. Manufactured with fibers extracted from fenugreek seeds, it bolsters the bioavailability of fisetin for longer times and enhances its effectiveness. Furthermore, this product does not contain any gluten or animal byproducts; each bottle contains 30 vegetarian capsules that have been designed to provide 45 mg of potent fisetin in every serving.

Gluten-freeFisetin supplements are not well regulated by the FDA, therefore the purity and quality of supplements can be an issue.
NON-GMO, VegetarianThere may also be potential interactions with medications.
Improve memory and cognitive function
Fibers Extracted

They created a formula that helps preserve fisetin, so you get the maximum benefit.

#4 Doctor’s Best Fisetin with Novusetin

Doctors best

Doctor’s Best Fisetin with Novusetin is a dietary supplement that provides you with two powerful compounds: fisetin, derived from natural sources like strawberries and apples, and novusetin – an artificial form of the flavonoid similar in structure to fisetin. Together they help support optimal health.

What are the benefits of Fisetin with Novusetin?

  • Flavonol is an antioxidant that helps defend against the effects of aging.
  • This compound can aid in protecting your brain from age-related decline.

Fisetin featuring Novusetin provides a naturally sourced flavonol that has demonstrated many impacts on brain cells and cognitive pathways in preclinical research. As a bioflavonoid antioxidant, it can help maintain glutathione levels and mitochondrial function when facing oxidative stress. Additionally, its potential to traverse the blood-brain barrier may aid in preserving neuronal functionality during conditions associated with normal aging decline.

#5 HUMANX Fisetin 500mg


Fisetin by HUMANX is made with premium quality ingredients, free of gluten and non-GMO. It is also formulated in a specialized vegetable cellulose capsule that helps to preserve the potency of the active ingredient. The capsules are easy to swallow and gentle on the digestive system.

Because Fisetin by HUMANX is a high dose of 500mg per capsule, users can be confident that they are getting the active ingredient at an optimal level for maximum health benefits.

With this supplement, you can support healthy aging and protect against age-associated diseases. Plus, it helps to manage senescent cells, promote cognitive function, and reduce inflammation. Try Fisetin by HUMANX today and you’ll be one step closer to a healthier, vibrant lifestyle!

Recommended Dosage for Fisetin Supplement Based on the Available Scientific Studies

When it comes to Fisetin supplements, the dosage may differ depending on which product you are using and what ailment is being treated. It should be noted that current research regarding this nutrient is still relatively limited; therefore, further investigation is necessary before determining an ideal quantity for supplementation. Nevertheless, some common dosages employed in clinical experiments include…

  • 50-100 mg per day
  • 30-50 mg per day
  • 80 mg per day

Adhering to the suggested dosage, as stated on the product label or prescribed by a healthcare provider is essential. It’s also crucial to bear in mind that supplements typically do not have FDA approval and may not always meet safety and efficacy standards like prescription drugs.

Thus, prior to beginning any dietary supplement regimen, it’s critical for you to speak with a licensed medical professional in order to ascertain if it’s secure and appropriate for your needs and comprehend how much of each nutritional element you should take per day.

Novusetin vs Fisetin

Flavonoids, a naturally occurring compound with antioxidant properties, have been intensively studied for their potential health advantages. Novusetin and fisetin are both members of this plant-based class of compounds that require more research to confirm their potency.

NovusetinRecent research published in the International Journal of Molecular Sciences has uncovered Novusetin’s promising potential as a neuroprotective agent, with its ability to shield neurons from deterioration and reduce brain swelling.

In 2017, Oncotarget journal unveiled a study that proposed fisetin may be used to treat cancer by inducing cell death in malignant cells. 2018’s Molecules journal also suggested that this naturally-occurring substance could act as a neuroprotective agent because of its anti-inflammatory properties and capability to defend neurons from damage.

It is critical to keep in mind that Novusetin and fisetin have not been approved by the FDA yet, so more research needs to be done on their safety and efficacy. Ultimately, both of these flavonoids contain promising health advantages such as neuroprotection and cancer prevention, but further studies are paramount to validate them.

Frequently Asked Questions

What Is the Difference Between Fisetin and Quercetin?

Fisetin and Quercetin are both powerful flavonoids, with antioxidant and anti-inflammatory properties. While they provide a wide range of health benefits such as controlling blood sugar levels, reducing swelling, preventing heart disease, and even fighting cancer; it is fisetin that has higher senolytic capabilities than quercetin when attempting to remove senescent cells from the body. Therefore, for those looking for greater cell rejuvenation effects – Fisetin may be your best choice!

Can Fisetin Be Taken if I Have Liver Disease?

With no known side effects or interactions with medications, fisetin might be a safe choice for those suffering from liver disease. Research indicates that this supplement may actually help treat ALD (alcoholic liver disease) by curbing oxidative stress; however, it is best to speak with your doctor before incorporating it into your regimen.

What is the Difference Between Bio Fisetin and Fisetin?

BioFisetin and fisetin are both natural flavonoid compounds found in various plants and fruits. However, they differ in their bioavailability and potential health benefits due to variations in their molecular structures and modes of administration.

Fisetin, chemically known as 3,3′,4′,7-tetrahydroxyflavone, is a polyphenol with antioxidant, anti-inflammatory, and neuroprotective properties. It exhibits potential therapeutic effects against age-related cognitive decline, oxidative stress, and chronic inflammation. Fisetin is naturally present in strawberries, apples, grapes, onions, and cucumbers. When consumed through dietary sources, its bioavailability can be limited due to poor absorption, rapid metabolism, and excretion.

BioFisetin, on the other hand, is a modified formulation of fisetin designed to enhance its bioavailability. This modification involves increasing its water solubility and stability, thereby improving its absorption and distribution within the body. BioFisetin may offer greater health benefits compared to standard fisetin due to its improved ability to cross cell membranes and reach target tissues.

Research suggests that both fisetin and BioFisetin exhibit potential as anti-cancer agents, as they have been shown to inhibit cancer cell growth and induce apoptosis. They also hold promise in combating neurodegenerative diseases by modulating signaling pathways related to neuroprotection and synaptic plasticity.

In conclusion, while fisetin is a naturally occurring flavonoid with various health-promoting properties, BioFisetin is a modified version designed to enhance its bioavailability and potential therapeutic effects. Choosing between the two depends on the desired health benefits and the mode of administration, with BioFisetin potentially offering an advantage in terms of improved absorption and cellular uptake.

Is it Safe to Take Fisetin Every Day?

The safety of daily fisetin supplementation depends on various factors, including dosage, individual health conditions, and interactions with other medications. While fisetin is a natural compound found in foods and is generally considered safe when consumed through dietary sources, the safety of long-term daily supplementation at higher doses has not been extensively studied in humans.

Current scientific literature suggests that fisetin possesses antioxidant, anti-inflammatory, and potential neuroprotective properties. It has shown promise in preclinical studies for its potential to combat age-related cognitive decline and certain health conditions. However, most research on fisetin’s health benefits and safety profile has been conducted in animal models or in vitro studies.

Regarding daily supplementation, caution is advised. High doses of any compound, even natural ones, can have unintended effects. Excessive fisetin consumption could potentially lead to gastrointestinal discomfort, allergic reactions, or interactions with other medications. Additionally, the lack of long-term human studies makes it challenging to establish a definitive safe dosage for daily fisetin intake.

If considering daily fisetin supplementation, it’s crucial to consult a healthcare professional before starting. They can provide personalized advice based on your health history, medications, and potential interactions. Furthermore, opting for dietary sources of fisetin, such as strawberries, apples, and other fruits, might be a safer way to incorporate this compound into your routine.


Despite the fact that studies on Fisetin are scarce, it’s still important to remember its potential advantages. Nevertheless, I should also be conscious of the need for more research regarding optimal dosage and usage techniques. Research conducted on animals has suggested that fisetin supplementation may be able to lower cholesterol levels in the blood – known as a hypocholesterolemic effect. The potential cause of this is attributed to its capability of decreasing absorption rates of cholesterol within the small intestines and increasing excretion rates out into feces.; thus proper safety and performance cannot always be guaranteed. I must always talk to a reliable healthcare professional before I start using any form of supplement in order to guarantee that it’s the right choice for me. Additionally, for successful results and safe consumption, it is important that I adhere strictly to the prescribed dosage on the product label or as recommended by my doctor; this will help prevent potential adverse reactions or drug interactions.

  • Fisetin Double Wood, brought to you by the esteemed brand Double Wood Supplements and containing a strong concentration of Fisetin, is not only non-GMO and gluten-free but has even been third-party tested for your assurance. Nonetheless, there is scarce information available regarding the purity or bioavailability of this supplement as well as its efficacy.
  • Renue LIPO Fisetin – This supplement is created by a well-known company and comes with liposomal encapsulation which improves absorption. It also complies with all Non-GMO, gluten-free, and vegetarian standards. Nevertheless, there are limited details available regarding the purity or bioavailability of this product along with its capability to deliver results effectively.
  • For those looking for a fiscally-friendly supplement with the added bonus of being gluten and GMO-free, Life Extension Bio-Fisetin is your go-to. It contains 30 vegetarian capsules to ensure maximum bioavailability and effectiveness sourced from fibers extracted from fenugreek seeds.

Despite this, it’s important to be aware that the FDA doesn’t regulate Fisetin supplements very well, which could mean potential quality issues or interactions with medications depending on what you take.