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5 Best Nicotinamide Riboside Supplements 2023 | Review

Every year, in the United States alone, billions of dollars are dedicated to anti-aging products. These items usually focus on reversing signs of aging that appear on the skin’s surface; however, Niagen (Nicotinamide Riboside) works from within your body for a more comprehensive approach!

As it enters your body, nicotinamide riboside is transformed into NAD+, a powerful molecule that enhances the function of every cell and can help you age healthily. To learn more about this nutrient—including its potential benefits, risks, and dosage recommendations—check out this article.

What Does NR Supplement Do?

Nicotinamide Riboside (NR) supplements can help support healthy aging and promote energy metabolism in the body.

NR is believed to heighten NAD+ levels, which are essential for DNA repair, energy levels production, and metabolic regulation within our cells.

Initial studies indicate that NR may promote cellular well-being and shield against declines in levels related to aging. Nevertheless, further research is required to comprehend its effects and potential benefits entirely.

As with any supplement, it’s essential to communicate with your doctor before you start taking NR to determine if it suits you personally and understands the risks and advantages associated with it.

5 Best Nicotinamide Riboside Supplements Review:

Thorne ResveraCel

Thorne ResveraCel

Thorne’s ResveraCel contains a unique form of nicotinamide riboside (NR) that boosts NAD+ levels in the body. As a direct precursor to NAD+, NR supports positive body functions such as DNA and cellular repair, energy production, and cellular communication.

Thorne uses only the purest ingredients to ensure unparalleled quality and is trusted by professional athletes and teams.

Thorne has also collaborated with Mayo Clinic on wellness research and is a proud partner of 11 U.S. Olympic Teams.


TRU Niagen

Tru Niagen 100mg is an introductory dose of nicotinamide adenine dinucleotide (NAD+) supplement. It’s meant to allow consumers to start with a lower dose and gradually increase it to the desired amount that works best for their bodies.

NAD+ is a crucial coenzyme in powering the 37.2 trillion cells in the body and is essential for their proper functioning.

The recommended daily serving size is 300mg, but it’s safe to consume up to 2,000mg per day, and studies have shown a more pronounced boost in NAD levels from taking as much as 1,000mg daily.

The 100mg capsule is an ideal way for consumers to optimize their NAD-boosting regimen.



Their supplement possesses 2000mg of Nicotinamide Riboside, an NAD+ precursor to elevate the body’s levels of NAD+.

It employs liposomal technology for enhanced absorption and also contains 200mg Trans-Pterostilbene, a powerful polyphenol, as well as 300 mg Betaine Anhydrous (TMG) to promote increased NAD+ concentrations and aid in healthy aging.

Their product is void of any GMOs or artificial ingredients; two soft gels daily are suggested for one month’s supply.

Ultra Health NR Liposomal Coated for Highest

Ultra Health NR Liposomal Coated for Highest

UltraHealth Nicotinamide Riboside (Cl) is a dietary supplement that contains nicotinamide riboside chloride, a form of the vitamin precursor nicotinamide riboside that can be converted into NAD+.

The brand claims to use a proprietary synthesis process to create ultra-high purity NR (99.5%) through double recrystallization steps.

UltraHealth also highlights that it is one of only two companies in North America that manufacture nicotinamide riboside chloride and that it publishes its percent purity results, allergen report, and certificate of analysis for added transparency.

The supplement is marketed as a way to improve cellular immunity and support NAD levels in the body, which can help with muscle recovery and performance.



Orgabay Liposomal is a dietary supplement that contains 1500 mg of nicotinamide riboside, a form of the vitamin precursor nicotinamide riboside that can be converted into NAD+.

The supplement uses liposomal technology for improved absorption and claims to directly boost NAD+ levels, improve energy production and support DNA and cellular repair.

The formula also includes trans-pterostilbene and betaine anhydrous to enhance the effects of NAD+ and improve overall health.

The brand touts high-quality control standards and the product is non-GMO, dairy-free, and free of extra additives and artificial flavorings. It is recommended to take 2 softgels daily for a 30-day supply.

Benefits and Side Effects. Is Nicotinamide Riboside Worth Taking?

Studies appear to suggest that NR may possess a few possible advantages., including:


  • Supporting healthy aging: Some studies have suggested that increasing levels of NAD+ in the body, which NR may help to do, may support healthy aging by promoting DNA repair and reducing oxidative stress.
  • Boosting energy metabolism: NR is involved in the process of converting food into energy, and some studies have suggested that it may help support cellular energy production.
  • Protecting against age-related declines in NAD+ levels: the levels decline with age, and some researchers believe that boosting NAD+ levels with NR may help to counteract some of the negative effects of aging on the body.

Research has shown that increasing NAD levels in the body through NR supplementation may enhance the efficacy of chemotherapy and radiation therapy, and may also have direct antiproliferative effects on cancer cells.

However, more research is needed to fully understand the relationship between NR and cancer and to establish its safety and efficacy as a treatment option.

There is limited research on the effects of nicotinamide riboside (NR) on testosterone levels. Some preliminary studies have suggested that NR supplementation may have potential as a treatment for age-related declines in testosterone, as increasing levels of NAD+  through NR may help regulate testosterone production.

Side Effects:

There have been relatively few studies on the safety and side effects of NR, and more research is needed to fully understand its potential risks.

However, some preliminary studies have suggested that NR may have some potential side effects, including:

  • Gastrointestinal issues: Some people have reported experiencing nausea, stomach cramps, and other gastrointestinal symptoms after taking NR.
  • Headaches: Some people have reported experiencing headaches after taking NR, although it’s unclear how common this side effect is.

Is Nicotinamide Riboside Worth Taking? While there is some evidence to suggest that NR may have potential benefits, more research is needed to fully understand its effects and potential risks.

As with any supplement, it’s important to talk to your healthcare provider before starting to take NR to determine if it’s right for you and to understand its potential benefits and risks.

To optimize healthy aging and well-being, it is paramount to adhere to a balanced diet, physical activity frequently abstains from smoking, and limit alcohol intake. Remember that dietary supplements should never be utilized as a substitute for nourishing food or lifestyle habits.


Researchers are still determining the ideal dosage of NR. Although NR is generally considered safe and well-tolerated, depending on your product type and purpose for the use, recommended dosages may vary.

Clinical trials have revealed that doses of 250-500 mg per day are most effective for increasing NAD+ levels in the body, though some studies suggest a higher dose could be even more beneficial. Nonetheless, further research is necessary to identify the optimal dosage as well as ensure its long-term safety.

Nicotinamide Riboside vs NMN Supplementation

Nicotinamide riboside (NR) and nicotinamide mononucleotide (NMN) are both precursors of nicotinamide adenine dinucleotide (NAD+), a coenzyme that plays a crucial role in cellular metabolism and energy production.

NR is a form of vitamin B3 (niacin) and is converted into NAD+ in the body. NR supplements are available as dietary supplements and have been shown to increase NAD+ levels in animal and human studies.

NMN, on the other hand, is a nucleotide that is directly converted into NAD+ in the cells, bypassing the initial step of NR conversion.

NMN supplements have also been shown to increase levels in animal studies and some preliminary human studies, but further research is needed to fully understand its effects.

In terms of their efficacy and safety, both NR and NMN have shown promising results in preclinical and limited human studies.

However, more research is needed to fully understand the long-term effects of supplementation and to establish safe and effective doses.

It is also important to note that individual factors such as age, diet, and lifestyle can affect the absorption and efficacy of these supplements, so it is recommended to consult a healthcare provider before starting any supplementation regimen.

Nicotinamide Riboside Chloride vs Nicotinamide Riboside

Nicotinamide riboside chloride (NRCl) and nicotinamide riboside (NR) are both forms of the vitamin precursor, NR. This molecule can be converted into NAD+ coenzyme by your body, contributing to a number of essential physiological processes.

NAD+ plays a key role in numerous metabolic activities, such as energy production, DNA restoration, and gene expression control. Nicotinamide riboside chloride (NRCl), commonly consumed through dietary supplementation, serves to replenish NAD+ levels within the body.

Nicotinamide riboside (NR) is the foundational form of this nutrient and is found in minuscule concentrations within milk and other edibles.

Evidence suggests that either form of NR may upsurge NAD+ levels within your body, potentially bringing valuable health rewards; however, further investigation needs to be undertaken to authenticate these hypotheses as well as determine optimal dosage amounts.

Frequently Asked Questions

What Supplement Has Nicotinamide Riboside in it?

Some popular supplements that contain Nicotinamide Riboside include Niagen, Basis, and TN. It’s often marketed as a way to support healthy aging, prevention of Alzheimer’s Disease and boost energy metabolism.

What is the Best Time to Take Nicotinamide Riboside?

How and when you take NR is entirely up to your discretion, however, the type of product used may influence this decision. Consuming it with food in the morning has been known to be beneficial for some individuals while other prefer taking it later on in the day.

Either way, finding what works best for you should always be a priority. To ensure optimal absorption and efficacy, it is best to take NR with meals. For personalized dosing advice, be sure to consult your healthcare provider.

Can Nicotinamide Riboside Reverse Aging?

Yes. Evidence suggests that Nicotinamide Riboside may be beneficial for supporting healthy aging, yet more research is needed to prove the extent of its effects. Currently available studies indicate it could boost cellular health, however only further exploration can reveal how this supplement might impact our ability to reverse and delay the effects of aging.

Before taking NR, it is essential that you consult with your healthcare provider to ensure the supplement would be advantageous for you and to discuss any potential benefits or risks.

What Does NR Do For the Body?

It’s widely accepted that NAD+ levels in the body are boosted when NR is introduced, which then triggers beneficial cellular activities such as DNA repair, energy generation, and metabolism regulation.

While various studies have suggested that NR may be able to support healthy aging, more research has yet to be conducted before its full effects and potential benefits on the human body can be identified.

Which is Better Tru Niagen or Elysium?

Determining which is better between TN and Elysium requires careful consideration of their specific ingredients and scientific evidence. Both supplements claim to support cellular health and longevity, primarily by increasing nicotinamide adenine dinucleotide (NAD+) levels in the body. NAD+ is a crucial coenzyme involved in various cellular processes, including energy production and DNA repair.

Tru Niagen’s main ingredient is nicotinamide riboside, a precursor to NAD+ synthesis. On the other hand, Elysium’s product Basis contains nicotinamide riboside and pterostilbene, a compound found in blueberries that may have antioxidant properties.

Research on nicotinamide riboside’s benefits is promising, indicating potential anti-aging effects and improved metabolic function in animal studies. Some human trials have also suggested NAD+ precursors might positively impact certain health aspects. Also, NAD supplementation has been linked to decreasing depression symptoms and improving overall cognitive function like memory recall and focus compared to those not taking the supplement.

However, while the science supporting NAD+ precursors is intriguing, more extensive and long-term human studies are needed to confirm their true efficacy and safety fully.

Ultimately, choosing between the two may come down to individual preferences, cost, and any underlying health conditions. It is advisable to consult with a healthcare professional before starting any new supplement regimen to ensure it aligns with individual health needs and goals.

Does Shannon Sharpe Really Use Tru Niagen?

Shannon Sharpe is a former NFL player and a well-known sports commentator. Celebrities, including athletes, often endorse products or supplements, but it’s essential to note that their endorsements don’t necessarily mean they personally use the product. Such endorsements are typically part of marketing agreements between the celebrity and the company selling the product.

Regarding Tru Niagen, it is a dietary supplement containing nicotinamide riboside, a precursor to NAD+ synthesis. While some studies have shown promising results regarding NAD+ precursors’ potential benefits, the scientific evidence is still developing, and the long-term effects on human health require further investigation.

To verify whether Shannon Sharpe personally uses TN, it would be best to check for any public statements or interviews where he specifically mentions using the product. However, as with any supplement, it’s always essential for individuals to consult with healthcare professionals before incorporating it into their regimen to ensure it aligns with their unique health needs and goals.


NR is an essential form of vitamin power that can be transformed into NAD+.

This special coenzyme has been associated with a wide array of potential benefits, including greater energy production, improved DNA restoration, and regulation of gene expression.

With such extensive advantages, it’s no wonder why this compound has become so popular in recent years!

Although we are still in the early stages of research on NR, what evidence currently exists implies that taking NR supplements may be an effective way to up your NAD+ levels and potentially gain health benefits.

That being said, more extensive studies must be done to gain better insight into how exactly this supplement works and its optimal dosage for long-term safety.